Cancer survival analysis on population-based cancer registry data in Zhejiang Province, China (2018–2019)

Huizhang Li , Youqing Wang , Weiwei Gong , Chen Zhu , Le Wang , Yaoyao Chen , Lingbin Du , Xiangdong Cheng
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Abstract

Objective

This is a comprehensive overview of long-term cancer survival in Zhejiang Province, China. Hybrid analysis, a combination of cohort and period analysis, has been proposed to derive up-to-date cancer survival estimates. Using this approach, we aimed to timely and accurately analyze the 5-year relative survival (RS) and net survival (NS) in cancer registries of Zhejiang Province, China.

Methods

A total of 255,725 new cancer cases diagnosed during 2013–2017 were included in 14 cancer registries in Zhejiang Province, China, with a follow-up on vital status until the end of 2019. The hybrid analysis was used to calculate the 5-year RS and 5-year NS during 2018–2019 for overall and stratifications by sex, cancer type, region, and age at diagnosis.

Results

During 2018–2019, the age-standardized 5-year RS and NS for overall cancer in Zhejiang was 47.5% and 48.6%, respectively. The age-standardized 5-year RS for cancers of women (55.4%) was higher than that of men (40.0%), and the rate of urban areas (49.7%) was higher than that of rural areas (43.1%). The 5-year RS declined along with age, from 84.4% for ages <45 years to 23.7% for ages >74 years. Our results of the RS and NS showed the similar trend and no significant difference. The top five cancers with top age-standardized 5-year RS were thyroid cancer (96.0%), breast cancer (84.3%), testicular cancer (79.9%), prostate cancer (77.2%), and bladder cancer (70.6%), and the five cancers with the lowest age-standardized 5-year RS were pancreatic cancer (6.0%), liver cancer (15.6%), gallbladder cancer (17.1%), esophageal cancer (22.7%), and leukemia (31.0%).

Conclusions

We reported the most up-to-date 5-year cancer RS and NS in Zhejiang Province, China for the first time, and found that the 5-year survival for cancer patients in Zhejiang during 2018–2019 was relatively high. The population-based cancer registries are recognized as key policy tools that can be used to evaluate both the impact of cancer prevention strategies and the effectiveness of health systems.

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中国浙江省基于人群的癌症登记数据的癌症生存分析(2018-2019年)
本文全面概述了中国浙江省的长期癌症生存率。混合分析法是将队列分析法和时期分析法结合起来,以得出最新的癌症生存率估计值。采用这种方法,我们旨在及时、准确地分析中国浙江省癌症登记的5年相对生存率(RS)和净生存率(NS)。方法在中国浙江省的14个癌症登记中,共纳入了255725例2013-2017年间确诊的新发癌症病例,并对其生命状态进行随访至2019年底。采用混合分析法计算了2018-2019年总体及按性别、癌症类型、地区和诊断时年龄分层的5年RS和5年NS。结果2018-2019年,浙江总体癌症的年龄标准化5年RS和NS分别为47.5%和48.6%。女性癌症的年龄标准化5年RS(55.4%)高于男性(40.0%),城市地区(49.7%)高于农村地区(43.1%)。5 年 RS 随年龄增长而下降,从 45 岁的 84.4% 降至 74 岁的 23.7%。我们的RS和NS结果显示出相似的趋势,没有明显差异。年龄标准化 5 年 RS 最高的五种癌症是甲状腺癌(96.0%)、乳腺癌(84.3%)、睾丸癌(79.9%)、前列腺癌(77.2%)和膀胱癌(70.6%),年龄标准化 5 年 RS 最低的五种癌症是胰腺癌(6.0%)、肝癌(15.6%)、胆囊癌(17.1%)、食管癌(22.7%)和白血病(31.0%)。结论我们首次报道了中国浙江省最新的癌症5年RS和NS,发现2018-2019年间浙江省癌症患者的5年生存率相对较高。基于人群的癌症登记被认为是重要的政策工具,可用于评估癌症预防策略的影响和卫生系统的有效性。
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