DIFFUSION-CURTOSIS MRI OF THE BRAIN IN DIFFERENTIAL DIAGNOSTICS OF METASTASES OF TUMORS OF VARIOUS PRIMARY LOCATION

Abstract

OBJECTIVE. The aim of this study is to improve the quality of differential diagnosis of metastases in the brain of tumors of different primary localization by introducing the diffusion-kurtosis magnetic resonance imaging technique into the MR-scanning protocol. MATERIALS AND METHODS. The study included 60 patients who underwent examination and treatment at the National Research Medical Center of Oncology named by N.N. Blokhin of the Ministry of Health of Russia from October 2019 to March 2022, in which, according to magnetic resonance imaging, metastatic formations in the substance of the brain of different localization of the primary tumor were detected. 20 patients were diagnosed with lung cancer (33.3%), 20 patients with breast cancer (33.3%) and 20 patients with melanomas (33.3%). 3%). We evaluated the tumor size, diffusion and kurtosis parameters, such as mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), kurtosis anisotropy (KA), radial diffusion (RD), fractional anisotropy (FA), relative anisotropy (RA), axial diffusion of the extra-axonal fluid (ADEAF), radial diffusion of the extra-axonal fluid (RDEAF), axonal fluid fraction (AFF), and tortuosity of the diffusion trajectory (TTD). RESULTS. Statistically significant (p0.05) differing parameters of diffusion and kurtosis in the comparative evaluation of indicators were identified in the structure of melanoma and lung cancer parameters - axial diffusion (AD), fractional anisotropy (FA), relative anisotropy (RA), radial kurtosis (RK) and tortuosity of the diffusion trajectory (ТTD) ), as well as in the structure of melanoma and breast cancer - axial diffusion (AD), axonal fluid fraction (FAF), fractional anisotropy (FA), axial diffusion of extra-axonal fluid (ADEAF), mean kurtosis (MK), relative anisotropy (RA), radial kurtosis (RK) and tortuosity of the diffusion trajectory (TTD).