COMPARATIVE ANALYSIS OF THE BIOLOGICAL PROPERTIES OF ETHANOL EXTRACTS OF THE GENUS MONARDA REPRESENTATIVES ON THE EXAMPLE OF DROSOPHILA MELANOGASTER

Q4 Pharmacology, Toxicology and Pharmaceutics INDIAN DRUGS Pub Date : 2023-11-28 DOI:10.53879/id.60.11.13711
O. Antosyuk, E. Bolotnik, Irina A. Sakova
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Abstract

Determination of toxic, genotoxic and cytotoxic effects of Drosophila melanogaster for Monarda fistulosa var. menthifolia, M. fistulosa, M. didyma and M. media was carried out. The Oregon-R line was used to test for toxic manifestations in a number of indicators: fecundity, early and late embryonic mortality of offspring and total lethality of individuals (LC50). The genotoxic effect was recorded using SMART. The change in the wing shape and regulated cell death was determined. The lethality of individuals grown on a nutrient medium with the addition of an extract of M. fistulosa var. menthifolia, as well as F1 offspring at the embryonic stage of development was studied. Genotoxicity was not registered for any of the tested extracts. The M. didyma extract is characterized by cytotoxic properties. An effect on viability was found for extracts of M. media and M. fistulosa var. menthifolia. Cytotoxic effect was observed when exposed to M. didyma extract.
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以黑腹果蝇为例比较分析猴面包树属代表植物乙醇提取物的生物特性
测定了黑腹果蝇对Monarda fistulosa var.menthifolia、M. fistulosa、M. didyma和M. media的毒性、遗传毒性和细胞毒性作用。利用俄勒冈-R品系测试了毒性表现的多项指标:繁殖力、后代早期和晚期胚胎死亡率以及个体总致死率(LC50)。使用 SMART 记录了基因毒性效应。测定了翅膀形状的变化和调节细胞的死亡。研究了在添加了 M. fistulosa var. menthifolia 提取物的营养培养基上生长的个体以及 F1 后代在胚胎发育阶段的致死率。未发现任何一种测试提取物具有遗传毒性。M.didyma萃取物具有细胞毒性特性。M. media 和 M. fistulosa var.在接触 M. didyma 提取物时,观察到了细胞毒性效应。
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INDIAN DRUGS
INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.30
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