Amid the ongoing Covid-19 pandemic, the quest for potent antiviral treatments intensifies. This study focuses on the potential of bioactive compounds from the Himalayan cedar Cedrus deodara against the SARS-CoV-2 virus. Specifically targeting the main protease (MPro) and spike protein, the study employs docking trials and molecular dynamics simulations. Compounds such as quercetin, dihydrodehydrodiconiferyl alcohol, and cedeodarin exhibit notable binding affinity, surpassing the reference drug favipiravir. Molecular dynamics simulations affirm the stability of these complexes throughout the simulation period. While these findings underscore promising interactions, it is crucial to emphasize the need for further research and experimental validation to fully explore the therapeutic capabilities of C. deodara in combatting Covid-19.
随着 Covid-19 病毒的不断流行，人们对强效抗病毒疗法的探索也在不断深入。本研究的重点是喜马拉雅雪松中的生物活性化合物对 SARS-CoV-2 病毒的潜在作用。该研究特别针对主蛋白酶（MPro）和尖峰蛋白，采用了对接试验和分子动力学模拟。槲皮素、二氢脱氢二硅氧烷醇和西地达林等化合物表现出显著的结合亲和力，超过了参考药物法非拉韦。分子动力学模拟证实了这些复合物在整个模拟期间的稳定性。尽管这些发现强调了有前景的相互作用，但仍需强调进一步研究和实验验证的必要性，以充分探索 C. deodara 在抗击 Covid-19 方面的治疗能力。
{"title":"COMPUTATIONAL IDENTIFICATION OF SELECTED BIOACTIVE COMPOUNDS FROM CEDRUS DEODARA AS INHIBITORS AGAINST SARS-COV-2 MAIN PROTEASE: A PHARMACOINFORMATICS STUDY","authors":"Aminabee Shaik, L. R. Atmakuri","doi":"10.53879/id.61.02.13859","DOIUrl":"https://doi.org/10.53879/id.61.02.13859","url":null,"abstract":"Amid the ongoing Covid-19 pandemic, the quest for potent antiviral treatments intensifies. This study focuses on the potential of bioactive compounds from the Himalayan cedar Cedrus deodara against the SARS-CoV-2 virus. Specifically targeting the main protease (MPro) and spike protein, the study employs docking trials and molecular dynamics simulations. Compounds such as quercetin, dihydrodehydrodiconiferyl alcohol, and cedeodarin exhibit notable binding affinity, surpassing the reference drug favipiravir. Molecular dynamics simulations affirm the stability of these complexes throughout the simulation period. While these findings underscore promising interactions, it is crucial to emphasize the need for further research and experimental validation to fully explore the therapeutic capabilities of C. deodara in combatting Covid-19.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"380 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juna B. Chacko, G. R. Vijayasankar, Bendi S. Venkateswarlu, Margret C. Rajappa
In our present study, solid lipid nanoparticles were fabricated by modified double emulsification followed by ultracentrifugation method. The SLNs of the anti-HIV drugs lamivudine, tenofovir disoproxil fumarate and efavirenz were synthesized using lipids Compritol 888 ATO, glyceryl monostearate, stearic acid and emulsifiers soy lecithin and Pluronic®F68. The synthesized SLNs were characterized for compatibility studies, mean particle size, PDI, zeta potential, surface morphology and entrapment studies. The higher amount of Compritol based SLNs formulation showed maximum entrapment efficiency with comparatively larger sized, homogenous particles. All the lipid based SLNs possessed no incompatibilities and showed high stability profiles. Based on the results of surface morphology, zeta potential and high entrapment efficiency values, the optimum lipid for SLNs formulation among the other lipids was determined to be Compritol 888 ATO.
{"title":"MECHANISTIC OUTCOMES OF LIPID CORE ON SOLID LIPID NANOPARTICLE CHARACTERIZATION","authors":"Juna B. Chacko, G. R. Vijayasankar, Bendi S. Venkateswarlu, Margret C. Rajappa","doi":"10.53879/id.61.02.13881","DOIUrl":"https://doi.org/10.53879/id.61.02.13881","url":null,"abstract":"In our present study, solid lipid nanoparticles were fabricated by modified double emulsification followed by ultracentrifugation method. The SLNs of the anti-HIV drugs lamivudine, tenofovir disoproxil fumarate and efavirenz were synthesized using lipids Compritol 888 ATO, glyceryl monostearate, stearic acid and emulsifiers soy lecithin and Pluronic®F68. The synthesized SLNs were characterized for compatibility studies, mean particle size, PDI, zeta potential, surface morphology and entrapment studies. The higher amount of Compritol based SLNs formulation showed maximum entrapment efficiency with comparatively larger sized, homogenous particles. All the lipid based SLNs possessed no incompatibilities and showed high stability profiles. Based on the results of surface morphology, zeta potential and high entrapment efficiency values, the optimum lipid for SLNs formulation among the other lipids was determined to be Compritol 888 ATO.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"66 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A quick reverse-phase high-performance liquid chromatography (RP-HPLC) approach for the quantitative measurement of temozolomide (TMZ) and (s) - perillyl alcohol [(S)-POH] in a nanoparticulate system was developed and validated in the current work. The RP-HPLC method for the simultaneous estimation of TMZ and (S)-POH was developed using Agilent (Infinity 1260) HPLC system and ZorbaxC18 (4.6 x 150 mm i.d., 5µ; Agilent) as stationary phase. The optimized mobile phase comprised of ACN: water: MeOH (42:12:46 V/V/V; 42:08:50 V/V/V and 20:30:50 V/V/V) pumped at a flow rate of 0.8 mL min-1, 0.8 mL min-1 and 1 mL min-1, respectively. Drug separation was accomplished in an isocratic mode, and a PDA detector operating at 210 nm was used to track elution. The procedure was validated in accordance with ICH-Q2R1 standards. The responses of TMZ and (S)- POH were found to be linear at 50-175 μg mL-1 (ACN: water: MeOH 42:12:46 V/V/V and 42:08:50 V/V/V) and 50-175 μg mL-1 (ACN: water: MeOH 20:30:50 V/V/V) respectively. The percent recovery was determined to be between 97% and 103%, demonstrating that the method’s accuracy was adequate. The precision study’s percent relative standard deviation (% RSD) was less than 2, indicating the accuracy of the suggested procedure. It was discovered that the established method for the quantitative determination of TMZ and (S)- POH in bulk and in hollow gold nanoparticles was accurate, precise, and specific. The developed technique can be applied to TMZ and (S)- POH routine testing and quality control in bulk and nanoparticulate systems.
{"title":"RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF TEMOZOLOMIDE AND (S) - PERILLYL ALCOHOL IN NANOPARTICULATE DOSAGE FORM","authors":"N. Desai, M. Momin, Tabassum Khan","doi":"10.53879/id.61.02.13782","DOIUrl":"https://doi.org/10.53879/id.61.02.13782","url":null,"abstract":"A quick reverse-phase high-performance liquid chromatography (RP-HPLC) approach for the quantitative measurement of temozolomide (TMZ) and (s) - perillyl alcohol [(S)-POH] in a nanoparticulate system was developed and validated in the current work. The RP-HPLC method for the simultaneous estimation of TMZ and (S)-POH was developed using Agilent (Infinity 1260) HPLC system and ZorbaxC18 (4.6 x 150 mm i.d., 5µ; Agilent) as stationary phase. The optimized mobile phase comprised of ACN: water: MeOH (42:12:46 V/V/V; 42:08:50 V/V/V and 20:30:50 V/V/V) pumped at a flow rate of 0.8 mL min-1, 0.8 mL min-1 and 1 mL min-1, respectively. Drug separation was accomplished in an isocratic mode, and a PDA detector operating at 210 nm was used to track elution. The procedure was validated in accordance with ICH-Q2R1 standards. The responses of TMZ and (S)- POH were found to be linear at 50-175 μg mL-1 (ACN: water: MeOH 42:12:46 V/V/V and 42:08:50 V/V/V) and 50-175 μg mL-1 (ACN: water: MeOH 20:30:50 V/V/V) respectively. The percent recovery was determined to be between 97% and 103%, demonstrating that the method’s accuracy was adequate. The precision study’s percent relative standard deviation (% RSD) was less than 2, indicating the accuracy of the suggested procedure. It was discovered that the established method for the quantitative determination of TMZ and (S)- POH in bulk and in hollow gold nanoparticles was accurate, precise, and specific. The developed technique can be applied to TMZ and (S)- POH routine testing and quality control in bulk and nanoparticulate systems.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"111 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study, meloxicam (MXM) chewable tablets were formulated and evaluated with an aim of improving its solubility, bioavailability and masking its bitter taste in order to create an effective oral drug delivery system. Meloxicam (BCS class II drug), non steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties, acts by inhibition of prostaglandin synthetase leading to inhibition of prostaglandin synthesis. MXM chewable tablets were made by three different techniques: AG (aqueous granulation), NAG (non-aqueous granulation) and DC (direct compression). The chewable tablets of MXM so prepared were assessed for various parameters, namely, palatability test, hardness, weight variation, mechanical strength, disintegration, friability, percent assay and in vitro testing for dissolution profile. The variation found in dissolution profile for all prepared batches was in the order: DC>NAG>AG. The percent assay was found within the range (90-110%). Observations from palatability study showed good overall tolerance levels for DC and AG and moderate tolerance levels for NAG.
本研究对美洛昔康（MXM）咀嚼片进行了配制和评估，目的是提高其溶解度和生物利用度，并掩盖其苦味，从而创造出一种有效的口服给药系统。美洛昔康（BCS II 类药物）是一种非甾体抗炎药（NSAID），具有镇痛和解热作用，其作用原理是抑制前列腺素合成酶，从而抑制前列腺素的合成。MXM 咀嚼片采用三种不同的技术制成：AG（水性制粒）、NAG（非水性制粒）和 DC（直接压制）。对制备的 MXM 咀嚼片进行了各种参数评估，即适口性测试、硬度、重量变化、机械强度、崩解度、易碎性、百分含量测定和体外溶出度测试。发现所有制备批次的溶出曲线变化顺序为DC>NAG>AG。化验百分率在 90-110% 的范围内。适口性研究表明，DC 和 AG 的总体耐受性良好，NAG 的耐受性适中。
{"title":"PREPARATION AND EVALUATION OF MELOXICAM CHEWABLE TABLETS FOR BETTER ORAL DELIVERY","authors":"Garima Sharma, Manish Dhall","doi":"10.53879/id.61.02.14061","DOIUrl":"https://doi.org/10.53879/id.61.02.14061","url":null,"abstract":"In the current study, meloxicam (MXM) chewable tablets were formulated and evaluated with an aim of improving its solubility, bioavailability and masking its bitter taste in order to create an effective oral drug delivery system. Meloxicam (BCS class II drug), non steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties, acts by inhibition of prostaglandin synthetase leading to inhibition of prostaglandin synthesis. MXM chewable tablets were made by three different techniques: AG (aqueous granulation), NAG (non-aqueous granulation) and DC (direct compression). The chewable tablets of MXM so prepared were assessed for various parameters, namely, palatability test, hardness, weight variation, mechanical strength, disintegration, friability, percent assay and in vitro testing for dissolution profile. The variation found in dissolution profile for all prepared batches was in the order: DC>NAG>AG. The percent assay was found within the range (90-110%). Observations from palatability study showed good overall tolerance levels for DC and AG and moderate tolerance levels for NAG.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Studies on the development of effective and cost-effective oral drugs are the new priority of the pharmaceutical industry for the prevention and treatment of COVID-19. This work was based on the computational analysis of physicochemical parameters, pharmacokinetic and toxicological measurements, molecular docking and in silico measurement of the antiviral activity of 12 repositionable drugs. The Molinspiration platform (physical-chemical parameters), pkCSM® (absorption, distribution, metabolism and excretion), OSIRIS Property Explorer® (toxicological measurements), Seam® (Docking with the RdRp protein) and AVCpred server® (antiviral activity) were used. Considering the 12 selected repositionable drugs, molecular anchoring data with the RdRp protein, only the drug tilorone had lower binding energy than the control used in this study (Molnupiravir). Ledipasvir, daclatasvir and piperaquine showed the best percentage of antiviral inhibition considering the control pattern. ADMETox data showed that piperaquine has a high toxicological potential for mutagenesis, tumorigenesis and irritant effects. The findings of this study indicate that ledipasvir and daclatasvir showed greatest potential for inhibition RdRp and action against COVID-19.
{"title":"PHYSICOCHEMICAL AND PHARMACOKINETIC ANALYSIS AND DOCKING OF DRUG REPOSITIONING AGAINST SARS-COV-2: AN IN SILICO STUDY","authors":"Jackson A. Pereira, Eduardo D. Costa","doi":"10.53879/id.61.02.14233","DOIUrl":"https://doi.org/10.53879/id.61.02.14233","url":null,"abstract":"Studies on the development of effective and cost-effective oral drugs are the new priority of the pharmaceutical industry for the prevention and treatment of COVID-19. This work was based on the computational analysis of physicochemical parameters, pharmacokinetic and toxicological measurements, molecular docking and in silico measurement of the antiviral activity of 12 repositionable drugs. The Molinspiration platform (physical-chemical parameters), pkCSM® (absorption, distribution, metabolism and excretion), OSIRIS Property Explorer® (toxicological measurements), Seam® (Docking with the RdRp protein) and AVCpred server® (antiviral activity) were used. Considering the 12 selected repositionable drugs, molecular anchoring data with the RdRp protein, only the drug tilorone had lower binding energy than the control used in this study (Molnupiravir). Ledipasvir, daclatasvir and piperaquine showed the best percentage of antiviral inhibition considering the control pattern. ADMETox data showed that piperaquine has a high toxicological potential for mutagenesis, tumorigenesis and irritant effects. The findings of this study indicate that ledipasvir and daclatasvir showed greatest potential for inhibition RdRp and action against COVID-19.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"46 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vidhi Bhanushali, Celina Nazareth, Rakshanda S. Khorjuwenkar
A simple, accurate and economical UV spectroscopic method has been developed for the simultaneous estimation of olopatadine hydrochloride and montelukast sodium. The developed method is based on the determination of the two drugs using UV absorbance correction principle. The wavelengths chosen for analysis were 352 nm for montelukast sodium (as absorbance due to the other drug was nil at this wavelength) and 298.5 nm for olopatadine hydrochloride (corrected for absorbance due to montelukast sodium) with water as diluent. The Beer-Lambert’s range for the two drugs was found to be 2-100 μg mL-1 at 298.5 nm and 2-70 μg mL-1 at 352 nm for montelukast sodium with r2 of ≥ 0.990. The developed method was validated as per ICH guidelines and the percentage assay results were within acceptable limits. The developed method can thus be successfully used for the regular analysis of olopatadine hydrochloride and montelukast sodium in bulk and in combination.
{"title":"NOVEL UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND OLOPATADINE HYDROCHLORIDE USING ABSORBANCE CORRECTION PRINCIPLE","authors":"Vidhi Bhanushali, Celina Nazareth, Rakshanda S. Khorjuwenkar","doi":"10.53879/id.61.02.13426","DOIUrl":"https://doi.org/10.53879/id.61.02.13426","url":null,"abstract":"A simple, accurate and economical UV spectroscopic method has been developed for the simultaneous estimation of olopatadine hydrochloride and montelukast sodium. The developed method is based on the determination of the two drugs using UV absorbance correction principle. The wavelengths chosen for analysis were 352 nm for montelukast sodium (as absorbance due to the other drug was nil at this wavelength) and 298.5 nm for olopatadine hydrochloride (corrected for absorbance due to montelukast sodium) with water as diluent. The Beer-Lambert’s range for the two drugs was found to be 2-100 μg mL-1 at 298.5 nm and 2-70 μg mL-1 at 352 nm for montelukast sodium with r2 of ≥ 0.990. The developed method was validated as per ICH guidelines and the percentage assay results were within acceptable limits. The developed method can thus be successfully used for the regular analysis of olopatadine hydrochloride and montelukast sodium in bulk and in combination.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"8 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nitu Patidar, N. Farooqui, Darshan Jamindar, D. K. Mishra, Rajat Goyal, Hitesh Chopra, R. Gautam
The present research work aimed at the formulation of film-coated microspheres incorporating glibenclamide drug and their evaluation for the management of diabetes mellitus (DM). Microspheres were prepared by solvent evaporation methodology by the usage of ethyl cellulose as polymer, ethanol and dichloromethane as solvents and Tween 80® as a non-ionic surfactant. The film-coated membrane was prepared by pan coating method, incorporating ethyl cellulose, isopropyl alcohol, diethyl phthalate and sodium lauryl sulfate. This film membrane was coated on microspheres with the help of a spray gun. The efficiency of entrapment of the film coated microspheres of F5* batch, among different formulations, is highest and comes out to be in the range of 76.65±0.58. The percentage yield was observed to be 73.32±0.14. Morphological studies conducted by scanning electron microscope show spherical microspheres of uniform size. In vitro drug release study conducted of the coated microspheres of glibenclamide shows the highest amount of release of 97.44% in the F5*batch. The best-fit model was determined by the highest R2 value. Further, the developed formulation helps in reduction in dose dumping, with better patient compliance, and also masks the bitter taste of the drug.
{"title":"PREPARATION AND CHARACTERIZATION OF MICROSPHERES UTILIZING RATE-CONTROLLING MEMBRANES FOR THE MANAGEMENT OF DIABETES MELLITUS","authors":"Nitu Patidar, N. Farooqui, Darshan Jamindar, D. K. Mishra, Rajat Goyal, Hitesh Chopra, R. Gautam","doi":"10.53879/id.61.02.14270","DOIUrl":"https://doi.org/10.53879/id.61.02.14270","url":null,"abstract":"The present research work aimed at the formulation of film-coated microspheres incorporating glibenclamide drug and their evaluation for the management of diabetes mellitus (DM). Microspheres were prepared by solvent evaporation methodology by the usage of ethyl cellulose as polymer, ethanol and dichloromethane as solvents and Tween 80® as a non-ionic surfactant. The film-coated membrane was prepared by pan coating method, incorporating ethyl cellulose, isopropyl alcohol, diethyl phthalate and sodium lauryl sulfate. This film membrane was coated on microspheres with the help of a spray gun. The efficiency of entrapment of the film coated microspheres of F5* batch, among different formulations, is highest and comes out to be in the range of 76.65±0.58. The percentage yield was observed to be 73.32±0.14. Morphological studies conducted by scanning electron microscope show spherical microspheres of uniform size. In vitro drug release study conducted of the coated microspheres of glibenclamide shows the highest amount of release of 97.44% in the F5*batch. The best-fit model was determined by the highest R2 value. Further, the developed formulation helps in reduction in dose dumping, with better patient compliance, and also masks the bitter taste of the drug.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"237 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Reader, In current times, when countries like Singapore are relying mainly on "Gen AI" (General Artificial Intelligence) for hastening the growth and modernization of the pharma industry, pharma leaders like India need to incorporate the latest trends in digital to Gen AI in the curriculum of the pharmacy degree and post-graduate degrees.
亲爱的读者，当前，新加坡等国主要依靠 "Gen AI"（通用人工智能）来加速制药业的发展和现代化，印度等制药业领导者需要将数字化到 Gen AI 的最新趋势纳入药学学位和研究生学位的课程中。
{"title":"NEED/ROLE OF GENERATIVE AI IN PHARMACEUTICAL RESEARCH","authors":"","doi":"10.53879/id.61.02.p0005","DOIUrl":"https://doi.org/10.53879/id.61.02.p0005","url":null,"abstract":"Dear Reader, In current times, when countries like Singapore are relying mainly on \"Gen AI\" (General Artificial Intelligence) for hastening the growth and modernization of the pharma industry, pharma leaders like India need to incorporate the latest trends in digital to Gen AI in the curriculum of the pharmacy degree and post-graduate degrees.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"63 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The family Lauraceae includes various genus in which Litsea has around 200-400 varieties which are widely scattered in the tropical and semi-tropical zones. In China, Litsea species are used traditionally in many disease conditions such as bone pain, diarrhoea, edema, dyspepsia, gastroenteritis and colds. Litsea glutinosa has been traditionally used in the treatment of tumors by the local people of Chittagong Hill Tracts, Bangladesh. Also, 15 other Litsea species are reported to have cytotoxic activity against various cancer cell lines, making this genus a promising potential source of anticancer compounds. This review provides comprehensive information about the cytotoxicity potential of various species in the genus Litsea along with secondary metabolites responsible, and its potential utility in lung, breast, hepatocellular, ovarian, prostate, colon and cervical cancer therapeutics as a botanical product. The published cytotoxicity data of these plants are mainly based on in vitro studies with very few molecular levels and mechanistic studies conducted. The optimistic results of these 16 species open unexplored vistas of natural product chemistry and the anticancer potential of this genus.
{"title":"THE GENUS LITSEA: A REVIEW OF ITS CYTOTOXIC POTENTIAL AND PHYTOCHEMISTRY","authors":"Sayali Churi, Tabassum Khan","doi":"10.53879/id.61.02.12907","DOIUrl":"https://doi.org/10.53879/id.61.02.12907","url":null,"abstract":"The family Lauraceae includes various genus in which Litsea has around 200-400 varieties which are widely scattered in the tropical and semi-tropical zones. In China, Litsea species are used traditionally in many disease conditions such as bone pain, diarrhoea, edema, dyspepsia, gastroenteritis and colds. Litsea glutinosa has been traditionally used in the treatment of tumors by the local people of Chittagong Hill Tracts, Bangladesh. Also, 15 other Litsea species are reported to have cytotoxic activity against various cancer cell lines, making this genus a promising potential source of anticancer compounds. This review provides comprehensive information about the cytotoxicity potential of various species in the genus Litsea along with secondary metabolites responsible, and its potential utility in lung, breast, hepatocellular, ovarian, prostate, colon and cervical cancer therapeutics as a botanical product. The published cytotoxicity data of these plants are mainly based on in vitro studies with very few molecular levels and mechanistic studies conducted. The optimistic results of these 16 species open unexplored vistas of natural product chemistry and the anticancer potential of this genus.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"57 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kritika R. Saboo, Rohit R. Ghadge, Dhanashree P. Sanap, Sneha A. Agrawal
A UV-spectrophotometric method for the estimation of embelin isolated from Embelia ribes berries as per ICH guidelines Q2 (R1) was developed. It is simple, quick, accurate, and affordable. The wavelength of embelin was found to be 294.3 nm; and was linear in the concentration range 2-12 μg mL-1 with 0.997 correlation coefficient. The method was applied to pharmaceutical formulation and the drug estimated was found to be 97.99 % and was in good agreement with the label claim. The accuracy of the method was performed at three different levels, between 80 to 120 %; with % recovery obtained 98.54 - 99.98 %. The low values of % RSD indicate that the method is accurate and reproducible. Interday, intraday variations, and repeatability were studied as precision parameters. A lower % RSD value than 2 indicates the developed method is precise. Ruggedness of the proposed method was studied with the aid of two analysts.
{"title":"ESTABLISHMENT AND AUTHENTICATION OF A UV SPECTROPHOTOMETRIC APPROACH FOR MEASURING EMBELIN CONTENT IN BULK AND FORMULATED SAMPLE","authors":"Kritika R. Saboo, Rohit R. Ghadge, Dhanashree P. Sanap, Sneha A. Agrawal","doi":"10.53879/id.61.02.14489","DOIUrl":"https://doi.org/10.53879/id.61.02.14489","url":null,"abstract":"A UV-spectrophotometric method for the estimation of embelin isolated from Embelia ribes berries as per ICH guidelines Q2 (R1) was developed. It is simple, quick, accurate, and affordable. The wavelength of embelin was found to be 294.3 nm; and was linear in the concentration range 2-12 μg mL-1 with 0.997 correlation coefficient. The method was applied to pharmaceutical formulation and the drug estimated was found to be 97.99 % and was in good agreement with the label claim. The accuracy of the method was performed at three different levels, between 80 to 120 %; with % recovery obtained 98.54 - 99.98 %. The low values of % RSD indicate that the method is accurate and reproducible. Interday, intraday variations, and repeatability were studied as precision parameters. A lower % RSD value than 2 indicates the developed method is precise. Ruggedness of the proposed method was studied with the aid of two analysts.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"137 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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