The Role of Endoplasmic Reticulum Stress Sensor Protein CREB3L2 in the Development of Tissues and Tumors

Abstract

The endoplasmic reticulum plays an extremely important role in the process of cellular protein secretion. The cyclic AMP-responsive element-binding protein 3 (CREB3) transcription factor family is closely associated with the secretion and transport of proteins within the endoplasmic reticulum. As a member of the CREB3 transcription factor family, cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2) stands out as a non-classical sensor within the endoplasmic reticulum. CREB3L2 can detect and regulate endoplasmic reticulum pressure, exert control over the processes of protein transport and secretion, participate in the development of tumor cells, and is also closely linked to the development of certain human tissues and organs. This article aims to review the role of CREB3L2 in tissue development and disease, shedding light on the related mechanisms of CREB3L2 in cancer development. The goal is to provide insights and directions for further analysis of CREB3L2.