{"title":"A Brief Review of SPINK1 Studies","authors":"Latai Ga","doi":"10.54097/ijbls.v4i1.14","DOIUrl":null,"url":null,"abstract":"SPINK1, a trypsin inhibitor secreted by the pancreas, is closely associated with the development of pancreatitis. Additionally, SPINK1 exhibits multiple biological functions, acting as a trypsin inhibitor, a growth factor-like protein, and a negative regulator of autophagy. This paper reviews the role of the SPINK1 gene and its variants in pancreatitis development, its expression as TATI in cancer, and its role in oncogenesis.","PeriodicalId":507854,"journal":{"name":"International Journal of Biology and Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biology and Life Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54097/ijbls.v4i1.14","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
SPINK1, a trypsin inhibitor secreted by the pancreas, is closely associated with the development of pancreatitis. Additionally, SPINK1 exhibits multiple biological functions, acting as a trypsin inhibitor, a growth factor-like protein, and a negative regulator of autophagy. This paper reviews the role of the SPINK1 gene and its variants in pancreatitis development, its expression as TATI in cancer, and its role in oncogenesis.
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