Indicators of bioelectrical activity of the brain in duodenal ulcer in the acute stage depending on the presence of Helicobacter pylori in patientss

Abstract

Duodenal ulcer disease (DU) is one of the leading gastrointestinal disorders today. Research on the role of Helicobacter pylori (H. pylori) in the pathogenetic mechanisms of various pathological conditions in the human body, including DU, is highly relevant. Objective — to investigate the impact of H. pylori presence in patients with acute-stage DU on indicators of brain bioelectrical activity using electroencephalography (EEG). Materials and methods. This study focused on assessing the bioelectrical activity of the brain through EEG in patients with acute-stage DU. A total of 60 patients were subjected to neurological examinations, and they were assigned into two groups based on the presence or absence of H. pylori infection. The age range of the patients was 25 to 60 years, with an average age of (39.80 ± 1.29) years. The majority of patients were male (43 (71.7 %)). A control group consisting of 30 relatively healthy individuals without somatic pathology, aged between 25 and 60 years with an average age of (31.20 ± 1.27) years, was also formed. This control group had a predominance of male subjects (19 (63.3 %)). Statistical methods were employed to process the data. Results. Significant differences were observed in the indicators of brain bioelectrical activity between H. pylori-positive patients and H. pylori-negative patients, particularly in terms of the average amplitude of waves of different frequencies, the dominant frequency in each rhythm, interhemispheric asymmetry coefficients, and indices and power indices of general spectrum ranges. Conclusions. The differences in brain bioelectrical activity revealed by EEG data between patients with or without H. pylori in their microbiome suggest potential pathophysiological significance of H. pylori in somatoneurological interactions in cases of DU.