Atopic dermatitis and pregnancy

Abstract

Atopic dermatitis (AtD) is a chronic allergic skin disease, the most common of dermatoses during pregnancy. Exacerbation of AtD can be at any stage of pregnancy, its main causes are an increase in progesterone levels, the predominance of Th2 cytokines, psychoemotional stress, violations of the gastrointestinal tract. Changes occur in the clinical picture, the lesions on the face and extensor surfaces of the extremities, papules. Treatment options for pregnant women are limited due to the unethical nature of clinical trials. It is safe to use topical glucocorticosteroids, moisturizers, narrow-band UVB 311 nm, calcineurin inhibitors are relatively safe. In systemic therapy in severe cases, the use of cyclosporine or a short course of prednisone is recommended. It is possible to continue the course of azathioprine at a reduced dose. There is no evidence of the safety of selective immunosuppressants.