M. Rakhmatulina, I. N. Kondrakhina, Elena Petrovna Egorova, E. Novoselova, Georgy Traktirov
Background. Acne is one of the most common dermatoses, the presence of which significantly reduces the quality of life of patients. For patients with inflammatory, comedonal acne use of fixed combinations is a first-line therapy. Aims: to study the efficacy and safety of the Zerkalin Intensive (ZI) in the treatment of acne in comparison with the Effezel (EF). Methods: an open comparative study included 60 patients with acne: group 1 (n=30) received therapy with ZI, group 2 (n=30) with EF 1 time a day in the evening. The effectiveness of therapy was evaluated 2 weeks, 1, 2 and 3 months. Results: after 1 month of therapy, there was a significant improvement in 9 (30%) patients of the group 1 and in 9 (30%) patients of the group 2 (p=1,000), improvement – in 12 (40%) and 18 (60%) patients (p=0.106). After 2 months of using ZI and EF, complete resolution of rashes was observed in 11 (36.7%) and 6 (20%) (p=0.395), significant improvement in 13 (43.3%) and 11 (36.7%) (p=0.628), improvement in 6 (20%) and 13 (43.3%), respectively. After 3 months complete resolution of rashes was observed in 24 (80%) patients of the group 1 and in 12 (40%) patients of the group 2 (p=0.088), significant improvement in 5 (16.7%) and 11 (36.6%) patients (p=0.236), improvement in 1 (3.3%) and 7 (23.3%) patients, respectively. Against the background of the use of EF, 20 (66.7%) patients showed the appearance of slight dry skin and redness. No side effects were detected when using the ZI. Conclusions. A comparable high efficiency of ZI and EF in acne therapy has been established. Use of ZI made it possible to achieve the onset of a full clinical effect and a significant improvement in the clinical picture in a larger number of patients and in a shorter time.
背景。痤疮是最常见的皮肤病之一，它的出现大大降低了患者的生活质量。对于炎症性粉刺患者来说，使用固定复方制剂是一线治疗方法。目的：研究Zerkalin Intensive（ZI）与Effezel（EF）治疗痤疮的疗效和安全性比较。方法：对60名痤疮患者进行公开比较研究：第一组（30人）接受ZI治疗，第二组（30人）接受EF治疗，每天晚上1次。分别在 2 周、1 个月、2 个月和 3 个月后对疗效进行评估。结果：治疗 1 个月后，第 1 组的 9 名患者（30%）和第 2 组的 9 名患者（30%）的病情有了明显改善（P=1,000），12 名患者（40%）和 18 名患者（60%）的病情有了改善（P=0.106）。使用 ZI 和 EF 2 个月后，分别观察到 11（36.7%）和 6（20%）名患者的皮疹完全消退（p=0.395），13（43.3%）和 11（36.7%）名患者的皮疹明显好转（p=0.628），6（20%）和 13（43.3%）名患者的皮疹明显好转。3 个月后，观察到第一组 24 名（80%）和第二组 12 名（40%）患者的皮疹完全消退（P=0.088），分别有 5 名（16.7%）和 11 名（36.6%）患者的皮疹明显好转（P=0.236），1 名（3.3%）和 7 名（23.3%）患者的皮疹明显好转。在使用 EF 的背景下，20 名（66.7%）患者出现了轻微的皮肤干燥和发红现象。使用 ZI 时未发现任何副作用。结论ZI和EF治疗痤疮的高效性已得到证实。使用 ZI 可以使更多的患者在更短的时间内获得全面的临床疗效，并显著改善临床症状。
{"title":"Efficacy and safety of the combined drug (5% benzoyl peroxide + 1% clindamycin) in the treatment of acne: results of an open randomized comparative clinical study","authors":"M. Rakhmatulina, I. N. Kondrakhina, Elena Petrovna Egorova, E. Novoselova, Georgy Traktirov","doi":"10.25208/vdv16759","DOIUrl":"https://doi.org/10.25208/vdv16759","url":null,"abstract":"Background. Acne is one of the most common dermatoses, the presence of which significantly reduces the quality of life of patients. For patients with inflammatory, comedonal acne use of fixed combinations is a first-line therapy. \u0000Aims: to study the efficacy and safety of the Zerkalin Intensive (ZI) in the treatment of acne in comparison with the Effezel (EF). \u0000Methods: an open comparative study included 60 patients with acne: group 1 (n=30) received therapy with ZI, group 2 (n=30) with EF 1 time a day in the evening. The effectiveness of therapy was evaluated 2 weeks, 1, 2 and 3 months. \u0000Results: after 1 month of therapy, there was a significant improvement in 9 (30%) patients of the group 1 and in 9 (30%) patients of the group 2 (p=1,000), improvement – in 12 (40%) and 18 (60%) patients (p=0.106). After 2 months of using ZI and EF, complete resolution of rashes was observed in 11 (36.7%) and 6 (20%) (p=0.395), significant improvement in 13 (43.3%) and 11 (36.7%) (p=0.628), improvement in 6 (20%) and 13 (43.3%), respectively. After 3 months complete resolution of rashes was observed in 24 (80%) patients of the group 1 and in 12 (40%) patients of the group 2 (p=0.088), significant improvement in 5 (16.7%) and 11 (36.6%) patients (p=0.236), improvement in 1 (3.3%) and 7 (23.3%) patients, respectively. Against the background of the use of EF, 20 (66.7%) patients showed the appearance of slight dry skin and redness. No side effects were detected when using the ZI. \u0000Conclusions. A comparable high efficiency of ZI and EF in acne therapy has been established. Use of ZI made it possible to achieve the onset of a full clinical effect and a significant improvement in the clinical picture in a larger number of patients and in a shorter time.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"72 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Relevance. Perioral dermatitis is a common dermatosis that predominantly affects women aged 25-40 but is also observed in children and adolescents. The distinct localization of this condition in the perioral, perinasal, and periocular zones contributes to apparent psycho-emotional distress, markedly impairing patients' quality of life. Perturbations in the skin biotope, local immune dysregulation, and topical glucocorticosteroid use are among the primary etiological factors. Effective management involves addressing causative factors, discontinuation of topical steroids, adopting gentle skincare practices, and employing localized treatments like metronidazole, pimcrolimus, and activated zinc pyrithione. Maintenance therapy may be warranted in select cases. The purpose of this work is to review the current literature on the problem and to present original clinical observations concerning the utilization of activated zinc pyrithione in treating patients with this condition. Materials and methods. The article presents the results of the use of topical zinc pyrithione in patients spanning various age groups and exhibiting diverse degrees of perioral dermatitis severity. Discussion. Significant clinical evidence substantiates the remarkable efficacy and safety profile of activated zinc pyrithione in managing perioral dermatitis, both as a standalone therapeutic modality and as an integral component of combination therapy. Conclusions. The use of activated zinc pyrithione in the treatment of perioral dermatitis emerges as an efficacious and secure approach for treating mild to moderate forms of the condition. Keywords: orofacial dermatitis, skin microbiome, chronic inflammation, age periods, Demodex, Malassezia spp., S.aureus, activated zinc pyrithione
{"title":"Perioral dermatitis: nuances of the clinical picture and therapy in different age periods","authors":"T. Trapeznikova, O. Letyaeva, V. Gubina","doi":"10.25208/vdv14868","DOIUrl":"https://doi.org/10.25208/vdv14868","url":null,"abstract":"Relevance. Perioral dermatitis is a common dermatosis that predominantly affects women aged 25-40 but is also observed in children and adolescents. The distinct localization of this condition in the perioral, perinasal, and periocular zones contributes to apparent psycho-emotional distress, markedly impairing patients' quality of life. Perturbations in the skin biotope, local immune dysregulation, and topical glucocorticosteroid use are among the primary etiological factors. Effective management involves addressing causative factors, discontinuation of topical steroids, adopting gentle skincare practices, and employing localized treatments like metronidazole, pimcrolimus, and activated zinc pyrithione. Maintenance therapy may be warranted in select cases. \u0000The purpose of this work is to review the current literature on the problem and to present original clinical observations concerning the utilization of activated zinc pyrithione in treating patients with this condition. \u0000Materials and methods. The article presents the results of the use of topical zinc pyrithione in patients spanning various age groups and exhibiting diverse degrees of perioral dermatitis severity. \u0000Discussion. Significant clinical evidence substantiates the remarkable efficacy and safety profile of activated zinc pyrithione in managing perioral dermatitis, both as a standalone therapeutic modality and as an integral component of combination therapy. \u0000Conclusions. The use of activated zinc pyrithione in the treatment of perioral dermatitis emerges as an efficacious and secure approach for treating mild to moderate forms of the condition. \u0000Keywords: orofacial dermatitis, skin microbiome, chronic inflammation, age periods, Demodex, Malassezia spp., S.aureus, activated zinc pyrithione","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"59 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psoriasis is a chronic immune-associated disease of a multifactorial nature. The prevalence of the disease, chronic course, impact on the patient’s quality of life, as well as the connection with the risk of progression of various comorbid conditions necessitate a detailed and comprehensive approach to the treatment of this group of patients. There has been a correlation of psoriasis with the risk of many comorbid pathologies, such as psoriatic arthritis, metabolic syndrome, liver and kidney disorders. There is evidence in the literature about the relationship between chronic renal failure and psoriasis, but the data are limited and require further study. According to Russian clinical guidelines, for moderate and severe forms of psoriasis, the prescription of systemic immunosuppressive therapy, targeted and genetically engineered biological drugs is indicated. Of particular interest is the determination of management tactics and selection of therapy if a patient with psoriasis has concomitant pathology due to the lack of a sufficient number of safety studies taking into account this or that comorbidity. We present the data known to us from a literature review on the stated problem. In view of the need to expand the data of real clinical practice on the possible risks of managing patients with psoriasis, we present a description of our own clinical experience of using the inhibitor interleukin 17A in a patient with chronic renal failure and hemodialysis.
{"title":"Experience of using genetic engineering biological therapy in a patient with psoriasis and chronic renal failure under hemodialysis.","authors":"Elina Kulakova, Sergey Borisovich Rybalkin","doi":"10.25208/vdv16757","DOIUrl":"https://doi.org/10.25208/vdv16757","url":null,"abstract":"Psoriasis is a chronic immune-associated disease of a multifactorial nature. The prevalence of the disease, chronic course, impact on the patient’s quality of life, as well as the connection with the risk of progression of various comorbid conditions necessitate a detailed and comprehensive approach to the treatment of this group of patients. There has been a correlation of psoriasis with the risk of many comorbid pathologies, such as psoriatic arthritis, metabolic syndrome, liver and kidney disorders. There is evidence in the literature about the relationship between chronic renal failure and psoriasis, but the data are limited and require further study. According to Russian clinical guidelines, for moderate and severe forms of psoriasis, the prescription of systemic immunosuppressive therapy, targeted and genetically engineered biological drugs is indicated. Of particular interest is the determination of management tactics and selection of therapy if a patient with psoriasis has concomitant pathology due to the lack of a sufficient number of safety studies taking into account this or that comorbidity. We present the data known to us from a literature review on the stated problem. In view of the need to expand the data of real clinical practice on the possible risks of managing patients with psoriasis, we present a description of our own clinical experience of using the inhibitor interleukin 17A in a patient with chronic renal failure and hemodialysis.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"51 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Darier-White's follicular dyskeratosis is an autosomal dominant hereditary dermatosis, which is based on pathological keratinization due to impaired adhesion between keratinocytes, manifested mainly in the form of hyperkeratotic follicular papules on seborrheic areas of the skin. Therapy of rare genodermatosis still presents difficulties in the tactics of choosing a treatment method for each individual patient. Currently, there are no regulated methods of treating this disease. The article presents a clinical case of Darier-White's follicular dyskeratosis and demonstrates a successful experience in the treatment of rare genodermatosis.
{"title":"DARIER`S FOLLICULAR DYSKERATOSIS. EXPERIENCE OF SUCCESSFUL THERAPY.","authors":"M. Drozhdina, V. Bobro, Elena Derpalyuk","doi":"10.25208/vdv9840","DOIUrl":"https://doi.org/10.25208/vdv9840","url":null,"abstract":"Darier-White's follicular dyskeratosis is an autosomal dominant hereditary dermatosis, which is based on pathological keratinization due to impaired adhesion between keratinocytes, manifested mainly in the form of hyperkeratotic follicular papules on seborrheic areas of the skin. Therapy of rare genodermatosis still presents difficulties in the tactics of choosing a treatment method for each individual patient. Currently, there are no regulated methods of treating this disease. The article presents a clinical case of Darier-White's follicular dyskeratosis and demonstrates a successful experience in the treatment of rare genodermatosis.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Olisova, E. V. Sokolovskiy, V. Khairutdinov, Muza Kokhan, M. Rakhmatulina, S. Burova, L. Kotrekhova, A. Pirogova
Hidradenitis Suppurativa (HS) is a chronic recurrent skin disease characterized by development of autoimmune inflammation in the infundibulum of the hair follicle and apocrine sweat glands located in the axillary, inguinal, anogenital regions, submammary folds, near the areola of mammary glands and the umbilical region. HS is difficult to treat and has an extremely negative impact on the quality of life. HS is separated into a distinct clinical entity fundamentally different in etiopathogenesis from acute bacterial hidradenitis. The exact prevalence of HS is unknown, it varies greatly in different studies ranging from 0.03% to 4% in general population. The detection of IL-1, IL-23, and IL-17 in the lesions indicates the key role of autoimmune inflammation involving Th17-lymphocytes in the pathogenesis of HS. Risk factors include smoking, obesity, mechanical friction, genetic predisposition. The diagnosis of HS relies on three obligatory criteria: characteristic distribution, typical morphology of the lesions and relapsing, chronic disease course. There is no gold standard in assessing the severity of the disease, since all available scoring systems have many limitations, therefore many questions regarding this disease remain unsolved at present - from terminology and clear and most objective assessment criteria for the severity of the process to the development of native clinical guidelines.
{"title":"Hidradenitis Suppurativa (part 1): definition, epidemiology, etiology, diagnosis.","authors":"O. Olisova, E. V. Sokolovskiy, V. Khairutdinov, Muza Kokhan, M. Rakhmatulina, S. Burova, L. Kotrekhova, A. Pirogova","doi":"10.25208/vdv14876","DOIUrl":"https://doi.org/10.25208/vdv14876","url":null,"abstract":"Hidradenitis Suppurativa (HS) is a chronic recurrent skin disease characterized by development of autoimmune inflammation in the infundibulum of the hair follicle and apocrine sweat glands located in the axillary, inguinal, anogenital regions, submammary folds, near the areola of mammary glands and the umbilical region. HS is difficult to treat and has an extremely negative impact on the quality of life. HS is separated into a distinct clinical entity fundamentally different in etiopathogenesis from acute bacterial hidradenitis. The exact prevalence of HS is unknown, it varies greatly in different studies ranging from 0.03% to 4% in general population. The detection of IL-1, IL-23, and IL-17 in the lesions indicates the key role of autoimmune inflammation involving Th17-lymphocytes in the pathogenesis of HS. Risk factors include smoking, obesity, mechanical friction, genetic predisposition. The diagnosis of HS relies on three obligatory criteria: characteristic distribution, typical morphology of the lesions and relapsing, chronic disease course. There is no gold standard in assessing the severity of the disease, since all available scoring systems have many limitations, therefore many questions regarding this disease remain unsolved at present - from terminology and clear and most objective assessment criteria for the severity of the process to the development of native clinical guidelines.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"54 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. M. Sharova, V. Smolyannikova, S. I. Svishchenko, Egana S. Mekhdieva, Elena A. Prokudina, Asiyat А. Apsheva
The article presents a rare clinical case of the classic Kaposis sarcoma in a 56 years old man with lesions of the oral mucosa. This clinical case is of particular interest due to the difficulties of differential diagnosis of Kaposis sarcoma and lichen planus when mucous membranes are involved in the pathological process. The presented case emphasizes the importance of a histological examination of the biopsy in differential diagnosis of Kaposis sarcoma.
{"title":"A rare case of classic Kaposi’s sarcoma with a lesion of the oral mucosa.","authors":"N. M. Sharova, V. Smolyannikova, S. I. Svishchenko, Egana S. Mekhdieva, Elena A. Prokudina, Asiyat А. Apsheva","doi":"10.25208/vdv7626","DOIUrl":"https://doi.org/10.25208/vdv7626","url":null,"abstract":"The article presents a rare clinical case of the classic Kaposis sarcoma in a 56 years old man with lesions of the oral mucosa. \u0000This clinical case is of particular interest due to the difficulties of differential diagnosis of Kaposis sarcoma and lichen planus when mucous membranes are involved in the pathological process. \u0000The presented case emphasizes the importance of a histological examination of the biopsy in differential diagnosis of Kaposis sarcoma.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140679538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Antonova, M. Ufimtseva, Oleg G. Makeev, Maria A. Desyatova, E. Mylnikova, K. Nikolaeva, M. S. Efimova
Background: Atopic dermatitis (AtD) is one of the most common inflammatory skin diseases, affecting up to 20,0% of children and 2,0–8,0% of adults worldwide. Patients with atopic dermatitis usually have dry skin and itching, they are at higher risk of developing asthma, as well as allergic rhinitis. Features of the clinical course of AtD are associated with both interaction of genes and influence of environmental factors. Studying epigenetic mechanisms could provide understanding of the most likely mechanisms by which environmental factors influence gene expression and contribute to the development of AtD. The aim of the study is to conduct a comprehensive molecular genetic analysis (assessment of the level of global DNA methylation and expression of the filaggrin gene (FLG)) in patients with moderate to severe AtD. Material and methods: The case-control study was conducted from January, 2022, through June 2022. A total of 32 patients with AtD and 6 healthy volunteers were recruited. The level of global DNA methylation in blood samples of patients with AtD and healthy individuals was assessed. The filaggrin gene (FLG) expression was measured by polymerase chain reaction in blood samples. Results: A hypermethylation of the genome in patients with AtD is 2.3 times higher than the methylation of genome in controls (p=0,003). FLG gene (exon 3 position 7-8 and exon 1) expression in patients with AtD is decreased compared to control group. Conclusion: Interaction between genomic changes which are associated with mutations in key barrier and immune genes and environmental factors plays a fundamental role in the AtD pathogenesis. The current study found that the epigenome of AtD patients differs from healthy individuals. The study of pathogenetic mechanisms is the basis for the development of new methods of targeted therapy for this socially significant dermatosis.
{"title":"DNA METHYLATION PROFILE AND EXPRESSION OF THE PHYLLAGRIN GENE IN PATIENTS WITH ATOPIC DERMATITIS: CASE-CONTROL STUDY","authors":"S. Antonova, M. Ufimtseva, Oleg G. Makeev, Maria A. Desyatova, E. Mylnikova, K. Nikolaeva, M. S. Efimova","doi":"10.25208/vdv1403","DOIUrl":"https://doi.org/10.25208/vdv1403","url":null,"abstract":"Background: Atopic dermatitis (AtD) is one of the most common inflammatory skin diseases, affecting up to 20,0% of children and 2,0–8,0% of adults worldwide. Patients with atopic dermatitis usually have dry skin and itching, they are at higher risk of developing asthma, as well as allergic rhinitis. Features of the clinical course of AtD are associated with both interaction of genes and influence of environmental factors. Studying epigenetic mechanisms could provide understanding of the most likely mechanisms by which environmental factors influence gene expression and contribute to the development of AtD. The aim of the study is to conduct a comprehensive molecular genetic analysis (assessment of the level of global DNA methylation and expression of the filaggrin gene (FLG)) in patients with moderate to severe AtD. Material and methods: The case-control study was conducted from January, 2022, through June 2022. A total of 32 patients with AtD and 6 healthy volunteers were recruited. The level of global DNA methylation in blood samples of patients with AtD and healthy individuals was assessed. The filaggrin gene (FLG) expression was measured by polymerase chain reaction in blood samples. Results: A hypermethylation of the genome in patients with AtD is 2.3 times higher than the methylation of genome in controls (p=0,003). FLG gene (exon 3 position 7-8 and exon 1) expression in patients with AtD is decreased compared to control group. Conclusion: Interaction between genomic changes which are associated with mutations in key barrier and immune genes and environmental factors plays a fundamental role in the AtD pathogenesis. The current study found that the epigenome of AtD patients differs from healthy individuals. The study of pathogenetic mechanisms is the basis for the development of new methods of targeted therapy for this socially significant dermatosis.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" 1195","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140681647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Zaslavsky, I. A. Gorlanov, I. Belousova, E. S. Bolshakova, Anna A. Artykova, Ekaterina A. Lyamina, D. Kozlova
A clinical case of lymphomatoid papulosis in a 10-year-old boy is described, clinically characterized by the presence of ulcerating nodes that resolve with the atrophy formation. The patient’s differential diagnostic workup included cutaneous anaplastic large cell lymphoma, cutaneous tuberculosis, polyarteritis nodosa, erythema nodosum, deep lupus erythematosus, and alpha-1 antitrypsin deficiency. Based on the history, clinical picture, as well as laboratory and instrumental studies, the patient was diagnosed with lymphomatoid papulosis. During the examination, no concomitant neoplastic diseases were identified in the patient. All elements resolved with the outcome being hyperpigmented spots and atrophy. To date, the relapse-free period of the disease in the patient is 10 months.
{"title":"Lymphomatoid Papulosis. Case in pediatric dermatological clinical practice","authors":"D. Zaslavsky, I. A. Gorlanov, I. Belousova, E. S. Bolshakova, Anna A. Artykova, Ekaterina A. Lyamina, D. Kozlova","doi":"10.25208/vdv16752","DOIUrl":"https://doi.org/10.25208/vdv16752","url":null,"abstract":"A clinical case of lymphomatoid papulosis in a 10-year-old boy is described, clinically characterized by the presence of ulcerating nodes that resolve with the atrophy formation. The patient’s differential diagnostic workup included cutaneous anaplastic large cell lymphoma, cutaneous tuberculosis, polyarteritis nodosa, erythema nodosum, deep lupus erythematosus, and alpha-1 antitrypsin deficiency. Based on the history, clinical picture, as well as laboratory and instrumental studies, the patient was diagnosed with lymphomatoid papulosis. During the examination, no concomitant neoplastic diseases were identified in the patient. All elements resolved with the outcome being hyperpigmented spots and atrophy. To date, the relapse-free period of the disease in the patient is 10 months.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hair loss, cicatricial skin changes and chronic immune-mediated dermatoses are a serious social and medical problem, as they can lead to social maladjustment of a person due to changes in appearance, constant pain and itching. At the same time, the existing methods of their diagnosis and complex treatment need to be improved. This review discusses novel promising approaches to the diagnosis and treatment of chronic immune-mediated dermatosis, alopecia, and skin wounds based on exosomes, extracellular vesicles secreted by cells that have specificity and the ability to penetrate into other cells and transfer their contents represented by various regulatory molecules to them. The review collects available information on the origin and exosomes cargo, reveals their diagnostic potential, and provides information on the therapeutic potential of these stem cell-derived vesicles.
{"title":"THE ROLE OF EXOSOMES IN THE DIAGNOSIS AND TREATMENT OF IMMUNE MEDIATED DERMATOSIS, TREATMENT OF SKIN WOUNDS AND ALOPECIA","authors":"Revaz Zenaishvili, N. Palkina, T. Ruksha","doi":"10.25208/vdv11876","DOIUrl":"https://doi.org/10.25208/vdv11876","url":null,"abstract":"Hair loss, cicatricial skin changes and chronic immune-mediated dermatoses are a serious social and medical problem, as they can lead to social maladjustment of a person due to changes in appearance, constant pain and itching. At the same time, the existing methods of their diagnosis and complex treatment need to be improved. This review discusses novel promising approaches to the diagnosis and treatment of chronic immune-mediated dermatosis, alopecia, and skin wounds based on exosomes, extracellular vesicles secreted by cells that have specificity and the ability to penetrate into other cells and transfer their contents represented by various regulatory molecules to them. The review collects available information on the origin and exosomes cargo, reveals their diagnostic potential, and provides information on the therapeutic potential of these stem cell-derived vesicles.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Obraztsova, Ksenia M. Lagun, G.L. Katunin, M. V. Shpilevaya, N. Nosov
Background: The number of syphilis cases in the Russian Federation increased significantly in 2022. Control of heterogeneity of Treponema pallidum subtypes is important to monitor the emergence and spread of antibiotic-resistant strains Aims: To determine molecular subtypes and resistance to macrolides in Treponema pallidum isolates isolated in the Russian Federation in 2022. Materials and methods: We analyzed DNA isolated from 49 samples of clinical material obtained from patients from dermatovenerological treatment and prevention facilities in three federal districts (CFD, SFD, SCFD) of the Russian Federation in 2022 with diagnoses of primary syphilis and secondary syphilis. T. pallidum DNA isolation and confirmation of the presence of genetic material were performed according to the existing algorithms. To search for genetic determinants of resistance to macrolides, a fragment of the 23S rRNA gene was analyzed. Primary decoding of nucleotide sequences was performed in Sequencing Analysis 5.3.1. Mega 11 program was used to align the analyzed fragments of target genes to T.pallidum reference sequences. Results: In 2022, three subtypes of T.pallidum were identified in the territory of the represented federal districts of the Russian Federation: 14d/f, 14d/g, 14 d/d with continued dominance of subtype 14d/f. The macrolide-resistant subtype 14 d/d was identified in two federal districts, which is new for the Russian Federation. Conclusions: The population of T. pallidum continues to expand in the Russian Federation, including the emergence of azithromycin-resistant strains. The data obtained confirm the need for continuous monitoring of circulating strains and may facilitate understanding of their geographic distribution.
{"title":"Determination of molecular types and resistance to macrolides in Treponema pallidum isolates isolated in the Russian Federation in 2022.","authors":"O. Obraztsova, Ksenia M. Lagun, G.L. Katunin, M. V. Shpilevaya, N. Nosov","doi":"10.25208/vdv15827","DOIUrl":"https://doi.org/10.25208/vdv15827","url":null,"abstract":"Background: The number of syphilis cases in the Russian Federation increased significantly in 2022. Control of heterogeneity of Treponema pallidum subtypes is important to monitor the emergence and spread of antibiotic-resistant strains \u0000Aims: To determine molecular subtypes and resistance to macrolides in Treponema pallidum isolates isolated in the Russian Federation in 2022. \u0000Materials and methods: We analyzed DNA isolated from 49 samples of clinical material obtained from patients from dermatovenerological treatment and prevention facilities in three federal districts (CFD, SFD, SCFD) of the Russian Federation in 2022 with diagnoses of primary syphilis and secondary syphilis. T. pallidum DNA isolation and confirmation of the presence of genetic material were performed according to the existing algorithms. To search for genetic determinants of resistance to macrolides, a fragment of the 23S rRNA gene was analyzed. Primary decoding of nucleotide sequences was performed in Sequencing Analysis 5.3.1. Mega 11 program was used to align the analyzed fragments of target genes to T.pallidum reference sequences. \u0000Results: In 2022, three subtypes of T.pallidum were identified in the territory of the represented federal districts of the Russian Federation: 14d/f, 14d/g, 14 d/d with continued dominance of subtype 14d/f. The macrolide-resistant subtype 14 d/d was identified in two federal districts, which is new for the Russian Federation. \u0000Conclusions: The population of T. pallidum continues to expand in the Russian Federation, including the emergence of azithromycin-resistant strains. The data obtained confirm the need for continuous monitoring of circulating strains and may facilitate understanding of their geographic distribution.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"138 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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