Role of Injection Tranexamic Acid in Reducing Blood Loss in Peri Trochanter Fracture Surgeries

EAS Journal of Orthopaedic and Physiotherapy Pub Date : 2023-11-16 DOI:10.36349/easjop.2023.v05i06.001

Sumit Kamboj, Varun Thusoo

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Abstract

Background: For patients undergoing surgery for peritrochanteric fractures, blood loss is a big issue. The purpose of this study was to see if tranexamic acid (TXA) could reduce postoperative blood loss in individuals who had hip surgery for peritrochanteric fracture. Methods: A total of 69 patients with intertrochanteric fractures were enrolled in this prospective study. Patients are randomly divided into two groups. Group A patients received 200 mL (1 g) of TXA intravenously before peritrochanter surgery and Group B patients did not receive an injection of TXA. Haemoglobin and hematocrit values were measured preoperatively and postoperatively at days 1 and 3. Visible and hidden blood loss volumes were calculated on postoperative day 3. Results: The blood transfusion rate was reduced significantly in patients by injecting tranexamic acid before surgery. However, mean haemoglobin and hematocrit levels were not significantly different between patients who received injection tranexamic acid and those who did not receive injection tranexamic acid. Conclusion: TXA significantly reduced postoperative blood loss in patients with Peritrochanteric fractures who underwent surgery.

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氨甲环酸注射液在减少转子周围骨折手术失血量中的作用

背景：对于接受髋臼转子周围骨折手术的患者来说，失血是一个大问题。本研究旨在了解氨甲环酸（TXA）能否减少因转子周围骨折而接受髋关节手术的患者的术后失血量。研究方法共有 69 名转子间骨折患者参与了这项前瞻性研究。患者随机分为两组。A 组患者在转子周围手术前静脉注射 200 毫升（1 克）TXA，B 组患者不注射 TXA。术前和术后第 1 天和第 3 天测量血红蛋白和血细胞比容值。术后第 3 天计算显性和隐性失血量。结果显示术前注射氨甲环酸可显著降低患者的输血率。然而，注射氨甲环酸和未注射氨甲环酸的患者的平均血红蛋白和血细胞比容水平并无明显差异。结论氨甲环酸能明显减少接受手术治疗的转子周围骨折患者的术后失血量。

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