Formulation and Evaluation of Topical Poly Herbal Gel Consisting of Natural Antimicrobials for the Activity against Acne Vulgaris

Abstract

The purpose of this research paper is to find out which effective antibacterial substances are in different herbs and their use in acne vulgaris and hyperpigmentation. Herbal gel with four herbs mainly including Azadiracta indica, Hibiscus rosa sinesis, Piper Betle and Aloe barbadensis was formulated with a base gel. Two formulations were prepared and evaluated for pH, dispersibility, detergency, and zone of inhibition. Preliminary phytochemical evaluations of the extracts were performed according to the standard procedures. Later antimicrobial activity of the individual extracts and polyherbal gel was determined by the cup plate method. Phytochemical tests showed the presence of alkaloids, terpenoids, flavonoids, saponins, etc. A strong antibacterial effect was found for a polyherbal gel compared with individual extracts against acne vulgaris. Synergistic interaction between secondary plant metabolites present in each extract might be responsible for the better antimicrobial activity of the polyherbal gel.