A Comprehensive Guide to Paget’s Disease of Bone

Abstract

PDB is a long-standing pathological stateillustrated by aberrant bone remodeling and metabolism arising in structural anomalies of the bone tissue. While this disease may remain asymptomatic, mild symptoms such as joint and bone discomfort may be present. However, an early warning sign is intense nocturnal bone pain. Moreover, PDB may result in complications such as deafness, fractures, compression of cranial nerves or the spinal cord, and hydrocephalus. This disease is more frequently observed in individuals above the age of 50, affecting individuals of all races and ethnicities, with a slightly higher prevalence in males. Diagnosis of PDB involves comprehensive clinical assessment, patient history, and specialized tests. Pharmacological treatments such as bisphosphonates, calcitonin, and surgical intervention may be employed to manage the disease. Supplementation is essential to prevent hypocalcemia. PDB may lead to rare complications, including sarcomatous conversion of the pagetic lesion and high-output congestive heart failure which concerns healthcare professionals.