{"title":"Twinship and childhood atopic disease: understanding early-life factors among discordant twins","authors":"K. Zhang, J. Zhu, E. Terebessy, I. Fong, T. To","doi":"10.56164/pediatrrespirj.2023.34","DOIUrl":null,"url":null,"abstract":"Parents often question why one of their children would have asthma while their siblings do not. With twins, this is especially perplexing. The gene-environment interaction hypothesis suggests that early-life environmental exposures interact with genes, leading to asthma and atopic diseases. This study sought to investigate twins for potential early-life risk factors that modify the risk of asthma, allergic rhinitis","PeriodicalId":507533,"journal":{"name":"Pediatric Respiratory Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Respiratory Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56164/pediatrrespirj.2023.34","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Parents often question why one of their children would have asthma while their siblings do not. With twins, this is especially perplexing. The gene-environment interaction hypothesis suggests that early-life environmental exposures interact with genes, leading to asthma and atopic diseases. This study sought to investigate twins for potential early-life risk factors that modify the risk of asthma, allergic rhinitis