Letrozole Versus Tomoxifen in Infertile Woman with Clomiphene Citrate Resistant Polycystic Ovarian Syndrome

Abstract

Objectives: To compare the effects of Letrozole and Tamoxifen for induction of ovulation in clomiphene citrate resistant women with Polycystic Ovarian syndrome. Patients and Methods: A prospective randomized study was conducted in the Department of Obstetrics & Gynecology of Menoufia University Hospital. The study was carried out on 80 clomiphene citrate resistant women with polycystic ovary syndrome divided into Group (1): received letrozole 2,5 mg tab orally twice per day from day 3 to day 7 of the menstrual cycle for three successive cycles (40 women, odd numbers). Group (2): received Tamoxifen 20 mg tab once per day from day 3 to day 7 of the menstrual cycle for three successive cycles (40 women, even numbers). In both groups, 10000 IU hCG was administrated when at least one mature follicle more than 18mm was observed during folliculometry. Results: The mean number of follicles (≥18 mm) was higher in letrozole than tamoxifen group. Ovulation rate was significantly higher in letrozole than tamoxifen group (52.5% vs 20% ) .There were no statistically significant differences between both groups regarding pregnancy rate. Conclusion: Letrozole was eminent than tamoxifen in achieving a higher ovulation rate and should be considered for clomiphene