The Effect of Hyperhomocysteinemia, Low Serum Vitamin B12 and Folate on Increasing Lose of Bone Density and Increasing Incident of Osteoporotic Hip Fracture among Elderly Population

Abstract

Subjective: Many studies shown a relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes) Aim of the study: This systemic article review aims to revise the main researches related to this subject and find out whether there is a significant relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes) Methods: About 10retrospective and prospective (cohort) cross sectional related studies have been reviewed and analyzed for the purpose of reaching the results. High plasma homocysteine level (> 12μg/L), low serum vitamin B 12 level (< 200 μg/L)And low serum of vitamin B9(>140 μg/L) Discussion: Multiple medical and nutritional studies talk, discuss, and explain the relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes) Results: Most of the reviewed related researches have shown mild (weak) relationship between high plasma homocysteine level, low serum vitamin B12 and folate level, but this related researchhas shown mild significant relationship between high plasma homocysteine level, low serum vitamin B12 and folate and the increasing risk of incidental hip fracture. Keywords: Osteoporosis, Vitamin B12, Homocysteine, Folic Acid, Hip Fracture.