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A Study on electrographic abnormalities and troponin elevation in COVID-19 patients: A Bangladeshi Perspective 关于 COVID-19 患者电图异常和肌钙蛋白升高的研究:孟加拉国视角
Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.03
Dr. Syeda Masuma Kawsar
Background: In Bangladesh, COVID-19 patients frequently present with electrographic abnormalities and elevated troponin levels, indicative of cardiac stress. These observations highlight the virus's potential impact on cardiovascular health, necessitating vigilant monitoring and timely interventions to mitigate complications. Study Objective: This research aims to assess electrographic abnormalities and troponin elevation in COVID-19 patients within Bangladesh. Methods: Conducted retrospectively at a tertiary medical college and hospital, our study enrolled 100 consecutive adult COVID-19 patients. We analyzed baseline characteristics, lab results, and serial ECGs. Troponin I concentrations were measured using the Abbott Architect method (normal range: ≤0.05 ng/mL). Troponin levels were categorized as normal (0.00-0.05 ng/mL), mildly elevated (0.05-1 ng/mL), and significantly elevated (>1 ng/mL). ECGs were reviewed and interpreted. Results: The majority of patients (71%) were males aged 41-50. Common COVID-19 symptoms included dyspnea and cough (75%), followed by fever, fatigue, and malaise (80%). Gastrointestinal symptoms were seen in 20%, and 10% experienced anosmia or dysgeusia. Comorbidities included diabetes mellitus (65%), hypertension (60%), CKD (10%), coronary artery diseases (13%), and other cardiovascular diseases (5%). Abnormal LFTs were observed in 30%. Initial troponin levels averaged 0.18 ± 1.75 ng/mL, with a maximum of 2.55 ± 17.90 ng/mL. Mortality occurred in 25% of cases. Conclusion: Our findings suggest that ECG repolarization abnormalities may serve as markers of clinical severity, even in cases with mildly elevated troponin values in COVID-19 patients. Keywords: covid-19, electrographic abnormalities, troponin
背景:在孟加拉国,COVID-19 患者经常出现电图异常和肌钙蛋白水平升高,这表明患者存在心脏压力。这些观察结果凸显了该病毒对心血管健康的潜在影响,因此有必要对其进行警惕性监测并及时干预,以减少并发症的发生。研究目的:本研究旨在评估孟加拉国 COVID-19 患者的心电图异常和肌钙蛋白升高情况。研究方法我们在一所三级医学院和医院进行了回顾性研究,共招募了 100 名连续的 COVID-19 成年患者。我们分析了基线特征、实验室结果和连续心电图。肌钙蛋白 I 浓度使用雅培 Architect 方法进行测量(正常范围:≤0.05 纳克/毫升)。肌钙蛋白水平分为正常(0.00-0.05 纳克/毫升)、轻度升高(0.05-1 纳克/毫升)和显著升高(>1 纳克/毫升)。对心电图进行复查和解读。结果:大多数患者(71%)为男性,年龄在 41-50 岁之间。常见的 COVID-19 症状包括呼吸困难和咳嗽(75%),其次是发烧、疲劳和乏力(80%)。20%的患者有胃肠道症状,10%的患者有嗅觉障碍或味觉障碍。合并症包括糖尿病(65%)、高血压(60%)、慢性肾脏病(10%)、冠状动脉疾病(13%)和其他心血管疾病(5%)。30%的患者出现低密度脂蛋白(LFT)异常。初始肌钙蛋白水平平均为 0.18 ± 1.75 纳克/毫升,最高为 2.55 ± 17.90 纳克/毫升。25%的病例出现死亡。结论我们的研究结果表明,即使在肌钙蛋白值轻度升高的COVID-19患者中,心电图再极化异常也可作为临床严重程度的标志。关键词:COVID-19、心电图异常、肌钙蛋白
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引用次数: 0
Study of Clinicoetiological profile of hyponatremia patients admitted in Medical wards 内科病房收治的低钠血症患者的临床病因研究
Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.07
Dr Khwaja Mohammed Usman
Hyponatraemia is the most common electrolyte disorder in hospitalized patients. Its epidemiology depends on the serum sodium used to define hyponatraemia, which varies from study to study. It can be an early or even first sign of important underlying disease. It can be complicated by two types of neurological disorders cerebral oedema and osmotic demyelination syndrome. It is associated with increased morbidity and mortality rates in hospitalized patients, although it remains unclear whether these associations are mainly due to the underlying disease, direct effects of hyponatraemia, or a combination of both. Aims and Objectives - to study clinical profile of hyponatremia in hospitalized subjects. To study the aetiology of hyponatremia in hospitalized subjects. To assess morbidity and mortality due to hyponatremia. Materials and Methods - 100 patients with hyponatremia were studied. Most common symptoms were Lethargy and tremors, followed by headache, nausea, altered sensorium, convulsion and coma, in order. Hypervolemic hyponatremia is most common followed by euvolemic hyponatremia and hypovolemic hyponatremia. Euvolemic subjects had propensity to develop more severe and symptomatic hyponatremia. Dilutional hyponatremia is the most prevalent underlying pathophysiology of hyponatremia followed by diuretic use, SIADH, GI loss, Hypothyroidism, extra renal/GI loss and Cerebral salt wasting in order. Congestive cardiac failure was the most common cause of hypervolemic hyponatremia, followed by cirrhosis of liver and renal failure. Acute gastroenteritis was most common cause of hypovolemic hyponatremia. SIADH was the most common cause of euvolemic hyponatremia, followed by thiazide diuretics and hypothyroidism, in order.
低钠血症是住院病人最常见的电解质紊乱。其流行病学取决于用于定义低钠血症的血清钠,而不同的研究结果也不尽相同。它可能是重要潜在疾病的早期甚至首发症状。它可并发两种神经系统疾病:脑水肿和渗透性脱髓鞘综合征。它与住院患者的发病率和死亡率增加有关,但目前仍不清楚这些关联主要是由于潜在疾病、低钠血症的直接影响还是两者的共同作用所致。目的和目标--研究住院病人低钠血症的临床概况。研究住院病人低钠血症的病因。评估低钠血症的发病率和死亡率。材料与方法 - 研究对象为 100 名低钠血症患者。最常见的症状是倦怠和震颤,其次依次是头痛、恶心、感觉改变、抽搐和昏迷。高血容量性低钠血症最常见,其次是高血容量性低钠血症和低血容量性低钠血症。高血容量受试者倾向于出现更严重、症状更明显的低钠血症。稀释性低钠血症是低钠血症最普遍的潜在病理生理学原因,其次依次是使用利尿剂、SIADH、消化道丢失、甲状腺机能减退、肾外/消化道丢失和脑盐耗损。充血性心力衰竭是导致高血容量性低钠血症的最常见原因,其次是肝硬化和肾功能衰竭。急性肠胃炎是导致低血容量性低钠血症的最常见原因。SIADH 是造成高血容量性低钠血症的最常见原因,其次依次是噻嗪类利尿剂和甲状腺功能减退症。
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引用次数: 0
Challenges in Diagnosing and Managing Pulmonary Conditions: A Case Series Highlighting Pulmonary Tuberculosis and Lung Cancer 诊断和治疗肺部疾病的挑战:以肺结核和肺癌为重点的病例系列
Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.05
Dr Rajendra Tatu Nanavare
This study delves into the intricate challenges encountered in diagnosing and managing pulmonary conditions, focusing on tuberculosis (TB) and lung cancer, especially in individuals with a history of cancer treatment and tobacco use. Through a detailed analysis of clinical cases, we explore the complexities associated with TB reactivation post-cancer therapy and the hurdles in timely diagnosing lung cancer in tobacco users. Three cases are presented: A 60-year-old male with a history of pulmonary TB, bidi smoking, and a diagnosis of adenocarcinoma after presenting with persistent cough and imaging findings suggestive of lung cancer. A 57-year-old male, post-cancer treatment, presenting with cough, diagnosed with TB after immunosuppression, highlighting diagnostic challenges in this population. A 63-year-old female with a prolonged cough and blood streaks in sputum, not responding to anti-TB treatment, ultimately diagnosed with lung cancer due to tobacco use. These cases underscore the need for vigilant monitoring and early intervention in post-cancer individuals vulnerable to latent TB reactivation, comprehensive diagnostic approaches for immunocompromised patients, and heightened awareness of the association between tobacco use and lung cancer. The study emphasizes the importance of thorough assessments, timely interventions, and collaborative efforts among healthcare providers to optimize outcomes in patients with overlapping health concerns. In conclusion, this study sheds light on the complexities of managing patients with a history of cancer, TB, and tobacco use, advocating for a holistic approach in diagnosis and management to improve patient outcomes and quality of life. Further research and clinical guidelines are warranted to refine treatment strategies and enhance the care of individuals facing these dual health challenges. Keywords: Lung Cancer, Pulmonary Tuberculosis, Lung Cancer and Pulmonary.
本研究深入探讨了在诊断和管理肺部疾病时遇到的复杂挑战,重点关注肺结核(TB)和肺癌,尤其是有癌症治疗史和吸烟史的患者。通过对临床病例的详细分析,我们探讨了癌症治疗后肺结核再活化的复杂性,以及及时诊断烟草使用者肺癌的障碍。本文介绍了三个病例:一名 60 岁的男性,有肺结核病史,吸烟,因持续咳嗽和影像学检查提示肺癌而被诊断为腺癌。一名 57 岁的男性,癌症治疗后出现咳嗽,经免疫抑制后被诊断为肺结核,突显了这一人群在诊断方面的挑战。一名 63 岁女性,长期咳嗽,痰中带有血丝,对抗结核治疗无效,最终被诊断为因吸烟导致的肺癌。这些病例强调了对癌症后易潜伏肺结核再活化人群进行警惕性监测和早期干预的必要性、对免疫力低下患者采取综合诊断方法的必要性,以及提高对吸烟与肺癌之间关联的认识的必要性。该研究强调了全面评估、及时干预和医疗服务提供者之间通力合作的重要性,以便优化具有重叠健康问题的患者的治疗效果。总之,本研究揭示了管理有癌症、肺结核和吸烟史的患者的复杂性,提倡在诊断和管理中采用整体方法,以改善患者的预后和生活质量。有必要进一步开展研究并制定临床指南,以完善治疗策略,加强对面临双重健康挑战的患者的护理。关键词肺癌、肺结核、肺癌和肺。
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引用次数: 0
Tumoral Calcinosis (TC) of iliac Crest in a 70 year-Old Female: A Case Report 一名 70 岁女性的髂嵴肿瘤性钙化 (TC):病例报告
Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.01
Supriya Mehrotra
A seventy-year-old lady had a hard tumor mass in left sacroiliac region. She was operated. Biopsy was taken from the left iliac crest and histopathological examination was done. Tumor measured 3×2×2 cms approximately. It was chalky-white ball-like. Its surface was lobulated. Microscopically, it showed small and large areas of necrosis and calcification. Areas of mild-to-moderate lymphocytic infiltration were seen. Fibrosis and hyalinization were seen. Bony trabeculae and osteoid formation were also seen. The patient was finally diagnosed as a case of primary tumoral calcinosis of sacroiliac region. Keywords: Soft tissue calcification necrosis osteoid formation chronic inflammation
一位七十多岁的女士左侧骶髂区域有一个硬性肿瘤肿块。她接受了手术。从左侧髂嵴处进行了活检,并进行了组织病理学检查。肿瘤大小约为 3×2×2 厘米。肿瘤呈白垩白色球状。表面呈分叶状。显微镜下可见大小不一的坏死和钙化区域。可见轻度至中度淋巴细胞浸润区。可见纤维化和透明化。还可见骨小梁和类骨形成。患者最终被诊断为骶髂关节原发性肿瘤性钙化症。关键词软组织钙化 坏死 骨样形成 慢性炎症
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引用次数: 0
Clinicopathological Correlation of P53 Protein Expression in different Histological Subtypes of Gastric Carcinoma 不同组织学亚型胃癌中 P53 蛋白表达的临床病理学相关性
Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.04
Yasap Tana
Introduction: Gastric cancer is one of the common cancers after lung cancer worldwide, especially in the developing countries. p53 immunohistochemical expression has been proposed as a potential tool to evaluate the biological behavior of gastric cancer. However, its practical implication in gastric cancer prognosis or treatment by restoration of mutated p53 function is yet to be fully exploited. Hence, this study with the aim of assessing the yield of p53 expression in gastric carcinoma and its relationship with various clinicopathological parameters was formulated. Objectives: To assess immunohistochemical expression of p53 protein in different histological subtypes of gastric carcinoma cases and to study correlation between p53 protein expression and different clinicopathological parameters like age, gender, tumour location, gross pattern, histological types, degree of tumor differentiation and pathological staging in the above said cases. Materials and Methods: This was a hospital based cross-sectional study done over a period of 18 months on 60 cases of gastrectomies with proven histological diagnosis of gastric carcinoma. Observation and Results: Strong p53 expression was frequent among elderly male patients (>60 years) who had ulceroproliferative tumors, located at pyloric antrum belonging to pTNM stage IIIA. In 87% cases, it was expressed, predominantly in moderately differentiated intestinal type with serosal invasion. Also, cases even with no lymph node metastasis showed p53 expression. Conclusion: Few findings were contradictory to other similar studies e.g. lymph node negative cases showing P53 expression does not support the hypothesis of predicting lymph node status by p53 expression. No significant correlation between p53 expression and different clinicopathological parameters in gastric carcinoma cases was seen. Keywords: P53, immunohistochemical, clinicopathological, histological subtypes, metastasis
引言:胃癌是继肺癌之后全球常见的癌症之一,尤其是在发展中国家:p53 免疫组化表达已被认为是评估胃癌生物学行为的潜在工具。然而,其在胃癌预后或通过恢复突变的 p53 功能进行治疗方面的实际意义仍有待充分挖掘。因此,本研究旨在评估 p53 在胃癌中的表达量及其与各种临床病理参数的关系。研究目的评估不同组织学亚型胃癌病例中 p53 蛋白的免疫组化表达,并研究上述病例中 p53 蛋白表达与不同临床病理参数(如年龄、性别、肿瘤位置、大体形态、组织学类型、肿瘤分化程度和病理分期)之间的相关性。材料与方法:这是一项基于医院的横断面研究,历时 18 个月,对 60 例经组织学确诊为胃癌的胃切除术病例进行了研究。观察结果:在患有溃疡增生性肿瘤的老年男性患者(60 岁以上)中,p53 的强表达很常见,这些肿瘤位于幽门前部,属于 pTNM IIIA 期。在 87% 的病例中,它都有表达,主要是在有浆膜侵犯的中度分化肠型肿瘤中。此外,即使没有淋巴结转移的病例也有 p53 表达。结论一些发现与其他类似研究相矛盾,如淋巴结阴性病例显示 P53 表达并不支持通过 p53 表达预测淋巴结状态的假设。在胃癌病例中,p53表达与不同的临床病理参数之间没有明显的相关性。关键词P53、免疫组化、临床病理学、组织学亚型、转移
{"title":"Clinicopathological Correlation of P53 Protein Expression in different Histological Subtypes of Gastric Carcinoma","authors":"Yasap Tana","doi":"10.18535/jmscr/v12i03.04","DOIUrl":"https://doi.org/10.18535/jmscr/v12i03.04","url":null,"abstract":"Introduction: Gastric cancer is one of the common cancers after lung cancer worldwide, especially in the developing countries. p53 immunohistochemical expression has been proposed as a potential tool to evaluate the biological behavior of gastric cancer. However, its practical implication in gastric cancer prognosis or treatment by restoration of mutated p53 function is yet to be fully exploited. Hence, this study with the aim of assessing the yield of p53 expression in gastric carcinoma and its relationship with various clinicopathological parameters was formulated. Objectives: To assess immunohistochemical expression of p53 protein in different histological subtypes of gastric carcinoma cases and to study correlation between p53 protein expression and different clinicopathological parameters like age, gender, tumour location, gross pattern, histological types, degree of tumor differentiation and pathological staging in the above said cases. Materials and Methods: This was a hospital based cross-sectional study done over a period of 18 months on 60 cases of gastrectomies with proven histological diagnosis of gastric carcinoma. Observation and Results: Strong p53 expression was frequent among elderly male patients (>60 years) who had ulceroproliferative tumors, located at pyloric antrum belonging to pTNM stage IIIA. In 87% cases, it was expressed, predominantly in moderately differentiated intestinal type with serosal invasion. Also, cases even with no lymph node metastasis showed p53 expression. Conclusion: Few findings were contradictory to other similar studies e.g. lymph node negative cases showing P53 expression does not support the hypothesis of predicting lymph node status by p53 expression. No significant correlation between p53 expression and different clinicopathological parameters in gastric carcinoma cases was seen. Keywords: P53, immunohistochemical, clinicopathological, histological subtypes, metastasis","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"28 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous Glutathione: A Promising Therapy for the Alcoholic Liver Disease 静脉注射谷胱甘肽:治疗酒精性肝病的有效疗法
Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.02
D. Ck
Alcoholic liver disease (ALD) and sepsis are life-threatening conditions marked by severe oxidative stress. Chronic alcohol use triggers oxidative stress and inflammation that damages liver cells. Glutathione (GSH), a tripeptide consisting of gamma glutamyl cysteinyl glycine possesses a thiol group and participates in oxidation reduction reactions, acting as a principal cellular scavenger of free radicles. GSH is present in large concentrations in the liver, and its endogenous levels are depleted in ALD, exacerbating the condition. Intravenous GSH supplementation has shown promising results in improving liver function and reducing fibrosis markers in ALD patients. Intravenous GSH treatment has demonstrated the potential to reduce oxidative injury and mortality rates in patients with sepsis in the intensive care unit. The versatility of GSH in mitigating oxidative stress, inflammation, and tissue damage and proven safety and tolerability profile make it a valuable adjunct to current treatments. Further research is imperative to comprehensively unravel the therapeutic benefits of GSH injection adjunct to standard of care in patients with ALD and sepsis. Keywords: Glutathione, Alcoholic liver disease, Sepsis, Antioxidants, Intensive care unit, Intravenous
酒精性肝病(ALD)和败血症是以严重氧化应激为特征的危及生命的疾病。长期饮酒会引发氧化应激和炎症,从而损害肝细胞。谷胱甘肽(GSH)是一种由γ-谷氨酰胱氨酰甘氨酸组成的三肽,具有一个硫醇基团,参与氧化还原反应,是自由基的主要细胞清除剂。GSH 在肝脏中的浓度很高,ALD 患者的内源性 GSH 水平会被耗尽,从而加重病情。静脉补充 GSH 在改善 ALD 患者的肝功能和降低纤维化指标方面显示出良好的效果。静脉补充 GSH 有助于减少氧化损伤,降低重症监护室脓毒症患者的死亡率。GSH 在减轻氧化应激、炎症和组织损伤方面的多功能性以及经证实的安全性和耐受性使其成为当前治疗的重要辅助手段。要全面揭示 GSH 注射剂对 ALD 和败血症患者标准治疗的辅助治疗效果,进一步的研究势在必行。关键词谷胱甘肽 酒精性肝病 败血症 抗氧化剂 重症监护病房 静脉注射
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引用次数: 0
Evaluation of Critical Care Nurses' Compliance with the External Ventricular Drain Care Bundle for Critically ill Patients at Kenyatta National Hospital 评估肯雅塔国立医院重症监护护士对重症患者室外引流护理包的遵从情况
Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.06
Leah Nambiro Nanyanga
ntroduction: The External Ventricular Drain (EVD) care bundle involves insertion, maintenance, troubleshooting, and monitoring for issues related to EVD, which is primarily the responsibility of nurses. Despite significant efforts to address external ventricular drain-related infections (ERIs) in CCUs and other critical care units, current studies suggest a high prevalence rate of external ventricular-related infections, particularly in LMICs and low-resource settings. Material and Method: A mixed-method study was conducted at KNH Critical Care Units with a sample of 81 nurses. Data analysis of Quantitative continuous data was summarized using medians and interquartile ranges, and Categorical data was summarized using frequencies and proportions. Qualitative data was analyzed using manual thematic analysis. Results: Most respondents were between 30 and 40 years old, 43.2%, females were 75.3%, higher diplomas were 54.3%, and 4.9% specialized in EVD care. 48.1% had good knowledge of the EVD care bundle, 46.9% had fair knowledge, and 5% had poor knowledge. Binary logistic regression and chisquare tests showed no factors associated with knowledge of the EVD care bundle (P>0.05 chi-square). A basic diploma and no specialization in EVD care were associated with higher odds of a poor or fair knowledge of the EVD care bundle. Conclusion: Most nurses exhibited fair practice of EVD care bundle but Lacked continuous medical education on EVD care, poor supervision and feedback on EVD care practice, and guidelines on EVD care not being easily accessible and understandable emerged as substantial perceived barriers to EVD care bundle utilization.
导言:心室外引流管(EVD)护理捆绑包括插入、维护、故障排除和监测与 EVD 相关的问题,这主要是护士的职责。尽管在重症监护病房(CCU)和其他重症监护病房为解决心室外引流管相关感染(ERIs)问题做出了巨大努力,但目前的研究表明心室外引流管相关感染的发病率很高,尤其是在低收入和中等收入国家以及低资源环境中。材料与方法:在 KNH 重症监护病房进行了一项混合方法研究,抽样调查了 81 名护士。定量连续数据的数据分析采用中位数和四分位数间距,分类数据的数据分析采用频率和比例。定性数据采用手动主题分析法进行分析。结果大多数受访者年龄在 30 至 40 岁之间,占 43.2%,女性占 75.3%,具有高等学历的占 54.3%,4.9% 的受访者专门从事 EVD 护理工作。48.1%的人对 EVD 护理捆绑包有较好的了解,46.9%的人了解一般,5%的人了解较差。二元逻辑回归和卡方检验显示,EVD护理捆绑包的知识没有相关因素(P>0.05卡方)。基本文凭和没有 EVD 护理专业与对 EVD 护理捆绑包了解较少或一般的几率较高有关。结论大多数护士对 EVD 护理包的实践表现一般,但缺乏有关 EVD 护理的持续医学教育、对 EVD 护理实践的监督和反馈不力,以及 EVD 护理指南不易获取和理解,成为使用 EVD 护理包的主要障碍。
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引用次数: 0
The effects of physicien attire on consultation outcomes in primary health care, National Guard, Riyadh 医生着装对初级保健咨询结果的影响,利雅得国民警卫队
Pub Date : 2024-02-28 DOI: 10.18535/jmscr/v12i02.06
Joud Abdulshakur Basfar
Introduction A good Physician- patient relationship is the core of a successful primary health care. It is characterized by a two way interactions between the physician and the patient, where the patient is involved in the decision making(1) . The relationship between the physician and the patient can interfere significantly with the treatment adherence(2) . So it is necessary for the physician to work on building and preserving a good relationship from the first moment. The first impression is important to optimize healthcare outcomes(3) . Physician appearances, gender, nationality, age, speech and posture were found to affect patient’s first impression(3) . Also, it is found that once the first impression been developed, it will remain unchanged – most of the times- (3) . Gender preferences found to increase patient satisfaction in some settings(4) . For the intimate, and psychosocial issues, it is found to be preferred to have a physician of the same gender as a patient (4) . For the age preference, some studies found that patients preferred the physician to be between 30- 50 years (5) . Physician appearances is also an important factor affecting patient perception of the care provided (1)
导言 良好的医患关系是初级医疗保健成功的核心。它的特点是医生和患者之间的双向互动,患者参与决策(1)。医患关系会严重影响治疗的依从性(2)。因此,医生有必要从一开始就努力建立和维护良好的关系。第一印象对于优化医疗效果非常重要(3) 。研究发现,医生的外表、性别、国籍、年龄、言谈举止和姿势都会影响患者的第一印象(3)。此外,研究还发现,第一印象一旦形成,大多数情况下都不会改变(3)。在某些情况下,性别偏好会提高病人的满意度(4)。在亲密关系和社会心理问题上,研究发现患者更愿意选择与自己性别相同的医生(4)。在年龄偏好方面,一些研究发现患者希望医生的年龄在 30-50 岁之间(5)。医生的外表也是影响患者对所提供护理的看法的一个重要因素(1)。
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引用次数: 0
Digital Signal Processing Approaches in the field of Genomics: A Recent Trend 基因组学领域的数字信号处理方法:最新趋势
Pub Date : 2024-02-28 DOI: 10.18535/jmscr/v12i02.10
Shivani Saxena
Digital signal processing (DSP) techniques have emerged as powerful tools in the field of genomics, enabling researchers to extract valuable insights from complex genetic data. This research paper presents a comprehensive analysis of the recent trends and advance- ments in applying DSP approaches to genomics. The objective is to provide an overview of the transformative role of DSP in genomic data analysis, variant calling, and interpretation. By leveraging DSP methods such as filtering, feature extraction, time-frequency analysis, and machine learning algorithms, researchers can enhance the quality of genetic signals, identify genetic variants, and gain a deeper understanding of genomic processes. The paper highlights key applications of DSP in genomics, including DNA sequence analysis, RNA expression pro- filing, epigenetics, and genome-wide association studies. Additionally, the challenges associated with applying DSP techniques in genomics, such as signal noise, data in- tegration, and computational complexity, are discussed. This research paper serves as a valuable resource for researchers, bioinformaticians, and geneticists seeking to harness the power of DSP in genomics, advancing our knowledge of genetic diseases and paving the way for personalized medicine and precision healthcare. Keywords: Digital signal processing, Genome analysis, Feature extraction, DNA sequence analysis, RNA expression profiling.
数字信号处理(DSP)技术已成为基因组学领域的强大工具,使研究人员能够从复杂的基因数据中提取有价值的见解。本研究论文全面分析了将 DSP 方法应用于基因组学的最新趋势和进展。目的是概述 DSP 在基因组数据分析、变异调用和解释中的变革性作用。通过利用 DSP 方法(如滤波、特征提取、时频分析和机器学习算法),研究人员可以提高基因信号的质量、识别基因变异并加深对基因组过程的理解。论文重点介绍了 DSP 在基因组学中的主要应用,包括 DNA 序列分析、RNA 表达预测、表观遗传学和全基因组关联研究。此外,还讨论了在基因组学中应用 DSP 技术所面临的挑战,如信号噪声、数据整合和计算复杂性。这篇研究论文为研究人员、生物信息学家和遗传学家提供了宝贵的资源,帮助他们在基因组学中利用 DSP 的强大功能,促进我们对遗传疾病的了解,为个性化医疗和精准医疗铺平道路。关键词数字信号处理 基因组分析 特征提取 DNA 序列分析 RNA 表达谱分析
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引用次数: 0
Pathogenesis of EMA negative PR negative Microcystic Meningioma: A Case Report EMA 阴性 PR 阴性微囊性脑膜瘤的发病机制:病例报告
Pub Date : 2024-02-28 DOI: 10.18535/jmscr/v12i02.01
Supriya Mehrotra
A patient, aged 35 years female complained of headache. CT examination revealed a non-succable tumor at anterolateral aspect of dura. Tumor extended from the right cervicomedullary junction upto C7 level. Tumor was excised and multiple soft tissue pieces, together measuring 1.5×1×1 cm were cellected. All the pieces were sectioned. Tumor had a sieve-like and cyst-like appearance. Section showed a circumscribed globular tumor which consisted of proliferated bland spindle cells. Tumor had an edematous stroma and presented a microcystic appearance. The cells had elongated ovoid nuclei and mild eosinophilic cytoplasm. Several thin-walled vascular spaces were also seen in the tumor. Strong positive reaction was obtained with an anti-S100 antibody, suggesting a neural origin of tumor cells. Further, anti-Ki 67 antibody gave mild reaction (Ki67 index was 12%) suggesting benign neoplasm. Anti-CD 34 and anti-D2.40antibodies gave positive reactions (2+) with small blood vessels of the tumor. Keywords: Benign cystic neoplasm with similar behavior among various subtypes.
患者,女性,35 岁,主诉头痛。CT 检查发现硬脑膜前外侧有一个无法切除的肿瘤。肿瘤从右侧颈髓交界处一直延伸到 C7 水平。肿瘤被切除,多块软组织被切成 1.5×1×1 厘米大小。所有组织块均被切片。肿瘤外观呈筛状和囊状。切片显示肿瘤呈环状球形,由增生的平滑纺锤形细胞组成。肿瘤基质水肿,呈微囊状。细胞核呈拉长的卵圆形,胞浆呈轻度嗜酸性。肿瘤内还可见数个薄壁血管间隙。抗 S100 抗体呈强阳性反应,表明肿瘤细胞来源于神经。此外,抗 Ki 67 抗体反应轻微(Ki67 指数为 12%),提示为良性肿瘤。抗CD 34和抗D2.40抗体与肿瘤的小血管呈阳性反应(2+)。关键词:良性囊性肿瘤各种亚型表现相似的良性囊性肿瘤。
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Journal of Medical Science And clinical Research
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