Antioxidant in Oxidative Stress and Neurodegenerative Diseases

Tukur Zayyanu
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Abstract

Background: Natural substances have long been used for developing traditional medicines, and the production of innovative drugs is encouraged by the use of these natural ingredients. The key interaction between oxidative stress and inflammation in disease etiology is supported by mounting research. Reactive oxygen species (ROS) generated by inflammatory cells cause oxidative stress, which has been recognized as the key mediator of the relationship between inflammation and the spread for diseases. Curcumin (DFM), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are the three main components of the rhizomes of turmeric. That filters the superoxide radicals, nitric oxide, and hydrogen peroxide while inhibiting lipid peroxidation, a successful Nano medicine using a curcumin will result in treatment of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Aims: The goal of this research is to present a new current Nano biotechnological approach to disease treatment and the use of encapsulated Nano cur cumin for treatment of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases.
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氧化应激和神经退行性疾病中的抗氧化剂
背景:长期以来,天然物质一直被用于开发传统药物,利用这些天然成分鼓励创新药物的生产。越来越多的研究证实,氧化应激和炎症在疾病病因学中具有关键的相互作用。炎症细胞产生的活性氧(ROS)会导致氧化应激,而氧化应激已被认为是炎症与疾病传播之间关系的关键介质。姜黄素(DFM)、去甲氧基姜黄素(DMC)和双去甲氧基姜黄素(BDMC)是姜黄根茎中的三种主要成分。姜黄素能过滤超氧自由基、一氧化氮和过氧化氢,同时抑制脂质过氧化反应,成功使用姜黄素的纳米药物将有助于治疗与年龄有关的神经退行性疾病,如阿尔茨海默氏症和帕金森氏症。目的:本研究的目的是提出一种当前治疗疾病的新型纳米生物技术方法,以及使用封装的纳米姜黄素治疗老年痴呆症和帕金森病等与年龄有关的神经退行性疾病。
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