Gama ile Işınlanmış Klorpropamid ve Prokainamid Hidroklorür İlaç Hammaddelerinde Oluşan Serbest Radikallerin EPR Spektroskopisi ile Tanımlanması

Kerem Sütçü, Yunus Emre Osmanoğlu
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Abstract

In this study, it was aimed to determine the structural properties of free radicals formed by gamma irradiation in chlorpropamide and procainamide hydrochloride drug raw materials, which are widely used in medicine, by using electron paramagnetic resonance spectroscopy. As a result of gamma irradiation, it was determined that two different radicals were formed in both chlorpropamide and procainamide hydrochloride samples. It was suggested that –NĊH-, -NCH2ĊH2- and –NĊH-, -NĊHCH2- radicals were formed in chlorpropamide and procainamide hydrochloride samples, respectively. The simulated spectra closest to the experimental spectra recorded at room temperature of the samples studied in powder form were obtained using simulation software. The contributions of the proposed radicals to the experimental spectra were calculated. The g values of the obtained radicals and the hyperfine structure constants of the unpaired electrons were calculated.
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利用 EPR 光谱鉴定经伽马辐照的氯丙酰胺和盐酸普鲁卡因胺药物原材料中形成的自由基
本研究的目的是利用电子顺磁共振波谱法,测定广泛用于医药的氯丙酰胺和盐酸普鲁卡因胺药物原料经伽马射线照射后形成的自由基的结构特性。伽马辐照的结果表明,在氯丙酰胺和盐酸普鲁卡因胺样品中形成了两种不同的自由基。结果表明,在氯丙酰胺和盐酸普鲁卡因胺样品中分别形成了-N↪Lu_10AH-, -NCH2ĊH2- 和-N↪Lu_10AH-, -NĊHCH2- 自由基。使用模拟软件获得了与所研究的粉末状样品在室温下记录的实验光谱最接近的模拟光谱。计算了所提出的自由基对实验光谱的贡献。计算了所得自由基的 g 值和未配对电子的超频结构常数。
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