DRUG NEURO INFLUENCES IN ONCOHEMATOLOGY

Y. Shatokhin, I. Snezhko, E. V. Ryabikina, E. V. Degtereva
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Abstract

Modern drugs and schemes based on them, used in oncohematology, cause a high risk of developing many variants of neurological complications, including cytostatic-induced neurotoxicity of various origins, one of the severe complications of chemoradiotherapy. These side effects occur not only immediately after the administration of chemotherapy drugs, but also delayed, and therefore concern not only hematologists, oncologists, but also neurologists, therapists, general practitioners who carry out subsequent outpatient monitoring of patients. Reducing the clinical manifestations of these complications leads not only to an improvement in the quality of life of patients, but also to an increase in their survival. Knowledge of algorithms for early diagnosis of damage to the peripheral and central nervous system and the possibilities of using drug therapy to minimize their manifestations are necessary in the work of internists.
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药物神经对肿瘤血液学的影响
在血液化疗中使用的现代药物和以这些药物为基础的治疗方案极易引发多种神经系统并发症,包括各种原因的细胞抑制剂引起的神经毒性,这是放化疗的严重并发症之一。这些副作用不仅会在使用化疗药物后立即出现,也会延迟出现,因此,不仅血液科医生、肿瘤科医生,而且神经科医生、治疗师、对患者进行后续门诊监测的全科医生都会关注这些副作用。减少这些并发症的临床表现不仅能改善患者的生活质量,还能提高他们的生存率。了解早期诊断周围和中枢神经系统损伤的算法,以及使用药物治疗尽量减少其表现的可能性,是内科医生工作的必要条件。
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