DETERMINATION OF ANTIBIOTICS CEPHALOSPORIN SERIES WITH PIEZOELECTRIC SENSORS IN WATER SOLUTIONS

Abstract

The aim of the work was to create a piezoelectric sensor modified with a polymer with molecular imprints of cefuroxime for its subsequent determination in aqueous solutions. For the synthesis of MIP, we used a mixture containing a copolymer of 1,2,4,5-benzenetracarboxylic acid and 4,4'-diaminodiphenyl oxide produced by OJSC IIPP SPA Plastic (Moscow), as well as a solution containing template molecules. The resulting mixture was applied to the surface of the sensor electrode by stamping. After that, thermal imidization was carried out in an oven. Next, the sensors were cooled and placed in distilled water to remove the template. The resulting sensor was used to determine the content of the antibiotic cefuroxime in aqueous solutions using a calibration curve. For this, standard solutions of cefuroxime were prepared with concentrations of 1.0101 1.0107 g/dm3. The measurements made allowed us to conclude that with an increase in the antibiotic concentration in the analyzed solution, a decrease in the resonant frequency occurs. The calibration dependence is linear. The limit of detection of cefuroxime for the obtained sensor is 1.0105 g/dm3. To test the selectivity of the obtained sensor based on a polymer with molecular imprints, an analysis of an antibiotic similar in structure, cefazolin, was carried out. It has been established that the sensory system is selective only for the antibiotic that was used for the synthesis of MIP.