Formulation and Characterization of Solid Lipid Nanoparticles for Topical Delivery of Antibacterial Drug

Abstract

The aim of this study was to prepare and evaluate solid lipid nanoparticles for the skin delivery of Ciprofloxacin. Ciprofloxacin loaded solid lipid nanoparticles (SLNs) have been successfully developed by using a microemulsion technique. Three different formulations were prepared It was found that variation in the amount of ingredients had profound effects on the Ciprofloxacin loading capacity, mean particle size, size distribution of charge, morphology, and drug-lipid compatibility. At optimized process conditions, Ciprofloxacin loaded SLNs showed spherical particles with a mean particle size of 250 ɳm and 60% Ciprofloxacin incorporation efficacy was achieved. The SLN sustained the drug release for 6 h in vitro. The results suggest formulation could be used as a potential topical formulation for fungal infection.