Unveiling Revealing Nature's Bounty: A Comprehensive Exploration of Bioavailability in Natural Products

Abstract

Researchers are increasingly investigating marketing assertions related to natural products and supplements. In the modern era, the study of bioavailability has gained prominence as a burgeoning scientific discipline. This comprehensive review explores the bioavailability of natural products in pharmaceutical applications, shedding light on their intrinsic challenges and innovative strategies for improvement. The assessment encompasses the limitations including poor aqueous solubility, low permeability, and instability, which collectively impede the effective absorption of natural products in the human body hinder the effective utilization of these compounds, and underscores the critical need for enhanced bioavailability to unlock their full therapeutic potential. Such challenges have spurred research into innovative approaches to overcome these limitations and optimize bioavailability. In response to these challenges, this review highlights cutting-edge strategies, including nanoparticle formulations, lipid-based delivery systems, and prodrug design, as effective means to enhance bioavailability. These approaches aim to improve solubility, stability, and overall absorption, thereby maximizing the therapeutic efficacy of natural products in pharmaceutical formulations. Moreover, the review emphasizes the importance of understanding the interplay between formulation techniques and the physicochemical properties of natural products. By integrating these innovative approaches, researchers can tailor solutions to specific compounds, providing a roadmap for overcoming bioavailability limitations and advancing the integration of natural products into mainstream pharmaceutical practice.