Correlation between Age at First Menarche and Breast Cancer in Dr. Cipto Mangunkusumo National General Hospital Jakarta in 2010-2014

Abstract

Background: Breast cancer is one of the most common cancer among Indonesian females. Many risk factors can increase the chance of developing breast cancer. Hormonal factor seems to play a role in many cases of breast cancer. The aim of this research is to determine the relationship between age at menarche and breast cancer in Dr. Cipto Mangunkusumo National General Hospital Jakarta in 2010-2014.Methods: The retrospective research is using cross-sectional design study with random sampling technique. There are 98 samples. The samples were taken in Archive Unit of Anatomical Pathology of FMUI with a further investigation in Medical Record Unit and Medical Department of Surgery in Dr. Cipto Mangunkusumo National General Hospital Jakarta. The data were analyzed by using chi square test then Fisher test. Results: There is no statistically significant between age at menarche and breast cancer in Dr. Cipto Mangunkusumo National General Hospital Jakarta in 2010-2014 (p>0,05). The results of this study also indicate that the 40-49 year age group is the age group that has the highest number of breast cancer cases compared to other age groups. The age at first menstruation > 12 years was associated with the highest frequency of breast cancer cases in the study population. Conclusion: The age at first menstruation statistically did not significantly affect breast cancer incidence in Dr. Cipto Mangunkusumo Hospital Jakarta in 2010-2014. However, further research using different study designs and larger sample sizes required.