Introduction and Importance: Benign tumors of the liver are relatively rare in children. Mesenchymal hamartoma (MH) is a benign tumor of the liver. It is the second most common benign pediatric hepatic tumor after infantile hemangioma. Mostly it is seen in children less than 2 years of age. The diagnosis of this tumor is difficult because of nonspecific clinical symptoms and lack of definitive laboratory studies. The precise diagnosis of mesenchymal hamartoma relies on histological evaluation of the tissue.We hereby present a rare case in a 2 year old child with mesenchymal hamartoma and its diagnostic challenges. Case presentation: A 2 year old previously healthy male was referred to our institution for evaluation of a liver mass. He complained of loss of apetite and abdominal distension since last 10 weeks. He had no complaints of fever/trauma. Clinical findings and Investigations: On per abdomen examination,there was a presence of large, non tender hepatomegaly with no shifting dullness present. On radiological evaluation, Ultrasound abdomen showed solitary right lobe mass. On further imaging, CT scan of the abdomen was done which showed a large multiloculated lesion in right lobe liver with arterial enhancing intervening septae within.The lesion was compressing and displacing right portal vein and right hepatic vein. At that time, laboratory evaluation showed normal liver function tests, serum AFP and other blood parameters. Differentials of liver cyst, hydatid cyst and biliary cystadenoma was made. Intervention and outcome: After discussion in multidisciplinary care, he was planned for surgery which would provide the exact histological diagnosis also in such cystic lesion of liver.He was optimized for surgery and subsequently underwent right hepatectomy with resection of the ~14× 12 cm mass. No major periperative complications developed and patient was discharged from hospital on POD6. The pathological review of the resected mass showed mixture of bile ducts, vessels, irregular liver cell plates and loose mesenchyme containing variable sized cysts consistent with a mesenchymal hamartoma. He is asymptomatic at the time of regular follow-up visits. Relevance and Impact: Benign tumors of the liver are relatively rare in children. The diagnosis of mesenchymal hamartoma still remains a challenge with non –specific complaints, normal laboratory findings and delay in diagnosis can lead to complications from local compression. Though advance imaging can diagnose this entity if index of suspicion is high but Differentiating it from other tumors such as an undifferentiated embryonal sarcoma is difficult on imaging alone. Hence surgical excision is the gold standard for diagnosing to reach the final histological diagnosis and treating these entities.
{"title":"Paediatric Mesenchymal Hamartoma of Liver-A Diagnostic Dilemma","authors":"Manish Sahni, Ram Daga, Nishant Jangir, Suresh Singh, Rajgovind Sharma","doi":"10.31557/apjcc.2023.8.4.819-821","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.819-821","url":null,"abstract":"Introduction and Importance: Benign tumors of the liver are relatively rare in children. Mesenchymal hamartoma (MH) is a benign tumor of the liver. It is the second most common benign pediatric hepatic tumor after infantile hemangioma. Mostly it is seen in children less than 2 years of age. The diagnosis of this tumor is difficult because of nonspecific clinical symptoms and lack of definitive laboratory studies. The precise diagnosis of mesenchymal hamartoma relies on histological evaluation of the tissue.We hereby present a rare case in a 2 year old child with mesenchymal hamartoma and its diagnostic challenges. Case presentation: A 2 year old previously healthy male was referred to our institution for evaluation of a liver mass. He complained of loss of apetite and abdominal distension since last 10 weeks. He had no complaints of fever/trauma. Clinical findings and Investigations: On per abdomen examination,there was a presence of large, non tender hepatomegaly with no shifting dullness present. On radiological evaluation, Ultrasound abdomen showed solitary right lobe mass. On further imaging, CT scan of the abdomen was done which showed a large multiloculated lesion in right lobe liver with arterial enhancing intervening septae within.The lesion was compressing and displacing right portal vein and right hepatic vein. At that time, laboratory evaluation showed normal liver function tests, serum AFP and other blood parameters. Differentials of liver cyst, hydatid cyst and biliary cystadenoma was made. Intervention and outcome: After discussion in multidisciplinary care, he was planned for surgery which would provide the exact histological diagnosis also in such cystic lesion of liver.He was optimized for surgery and subsequently underwent right hepatectomy with resection of the ~14× 12 cm mass. No major periperative complications developed and patient was discharged from hospital on POD6. The pathological review of the resected mass showed mixture of bile ducts, vessels, irregular liver cell plates and loose mesenchyme containing variable sized cysts consistent with a mesenchymal hamartoma. He is asymptomatic at the time of regular follow-up visits. Relevance and Impact: Benign tumors of the liver are relatively rare in children. The diagnosis of mesenchymal hamartoma still remains a challenge with non –specific complaints, normal laboratory findings and delay in diagnosis can lead to complications from local compression. Though advance imaging can diagnose this entity if index of suspicion is high but Differentiating it from other tumors such as an undifferentiated embryonal sarcoma is difficult on imaging alone. Hence surgical excision is the gold standard for diagnosing to reach the final histological diagnosis and treating these entities.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139284003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-07DOI: 10.31557/apjcc.2023.8.4.763-770
Savita, Ashok Kumar, Nimarta, Puneet Pareek, Shrikant K. Nair
Background: Radiotherapy is the use of high energy ionizing radiation to treat diseases. With newer technological advancements, the application of radiotherapy in cancer treatment is increasing. Administration of radiation therapy requires great precision and competency, hence tools should be available to implement uniformity of care in the procedure of radiotherapy and to reduce medical errors. This necessitates the need of a checklist to serve as a standard guide for the procedure of radiotherapy. The objective of present study was to develop radiotherapy administration checklist for patients undergoing radiotherapy. Materials and methods: Radiotherapy administration checklist was developed by using methodological research design. The checklist was developed in five phases: i) the preliminary phase (including literature review, focused group discussion, assessment of current practices, generation of item pool and preparation of preliminary draft), ii) the validation phase (content validity by modified Delphi technique and construct validation by factor analysis), iii) pilot testing, iv) final try out followed by establishment of reliability (internal consistency and inter-rater reliability), v) evaluation phase. Results: The final draft of Radiotherapy administration Checklist consisting of 29 items was developed and the validity and reliability of the developed tool were established. In content validity, S-CVI/Avg. and S-CVI/UA were 0.97 and 0.79 respectively. Cronbach’s coefficient alpha, and interrater reliability were 0.64 and 0.76 respectively. All 29 items in final checklist were loaded under 8 factors. The checklist developed was found to be a valid and reliable tool for the procedure of Radiotherapy administration. Conclusion: Radiotherapy administration Checklist is a valid and reliable tool with psychometric properties within expected range. The Radiotherapy administration Checklist can be used as a standard tool to ensure safe, uniform and optimal delivery of radiotherapy.
{"title":"Radiotherapy Administration Checklist for Patients Undergoing Radiotherapy: Development and Validation","authors":"Savita, Ashok Kumar, Nimarta, Puneet Pareek, Shrikant K. Nair","doi":"10.31557/apjcc.2023.8.4.763-770","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.763-770","url":null,"abstract":"Background: Radiotherapy is the use of high energy ionizing radiation to treat diseases. With newer technological advancements, the application of radiotherapy in cancer treatment is increasing. Administration of radiation therapy requires great precision and competency, hence tools should be available to implement uniformity of care in the procedure of radiotherapy and to reduce medical errors. This necessitates the need of a checklist to serve as a standard guide for the procedure of radiotherapy. The objective of present study was to develop radiotherapy administration checklist for patients undergoing radiotherapy. Materials and methods: Radiotherapy administration checklist was developed by using methodological research design. The checklist was developed in five phases: i) the preliminary phase (including literature review, focused group discussion, assessment of current practices, generation of item pool and preparation of preliminary draft), ii) the validation phase (content validity by modified Delphi technique and construct validation by factor analysis), iii) pilot testing, iv) final try out followed by establishment of reliability (internal consistency and inter-rater reliability), v) evaluation phase. Results: The final draft of Radiotherapy administration Checklist consisting of 29 items was developed and the validity and reliability of the developed tool were established. In content validity, S-CVI/Avg. and S-CVI/UA were 0.97 and 0.79 respectively. Cronbach’s coefficient alpha, and interrater reliability were 0.64 and 0.76 respectively. All 29 items in final checklist were loaded under 8 factors. The checklist developed was found to be a valid and reliable tool for the procedure of Radiotherapy administration. Conclusion: Radiotherapy administration Checklist is a valid and reliable tool with psychometric properties within expected range. The Radiotherapy administration Checklist can be used as a standard tool to ensure safe, uniform and optimal delivery of radiotherapy.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139283984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The first presentaion of children with a malignancy is often an emergency. Pediatric oncological emergencies need to be recognized and managed early and effectively for a better outcome. In this prospective study of children, with oncological emergencies, we aimed to study the nature of oncological emergencies, emergency management and immediate outcome. There were 83 patients with 110 visits with median age of 6 years. Leukemia constituted 50.6% and 92.8% was acute lymphocytic, 26.5% intracranial malignancies 59% of them posterior fossa tumors. 36.4%, presented with fever, 18% severe anemia and 16.45 % febrile neutropenia, 8% TLS (tumor lysis syndrome) and 4.5% had respiratory distress as the presentation. Presenting symptoms in 31% were neurological. 42.7% required parenteral antibiotics and 16.4% packed cell tranfusion. 90.4% of blood cultures were negative. 26.5% needed intensive care, 12 required neurosurgical procedure.
{"title":"Management and Immediate Outcome of Common Pediatric Oncological Emergencies from a Single Centre","authors":"Radhika Raman, Sreenidhi Ramakrishna, Lakshmi Muthukrishnan","doi":"10.31557/apjcc.2023.8.4.783-786","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.783-786","url":null,"abstract":"The first presentaion of children with a malignancy is often an emergency. Pediatric oncological emergencies need to be recognized and managed early and effectively for a better outcome. In this prospective study of children, with oncological emergencies, we aimed to study the nature of oncological emergencies, emergency management and immediate outcome. There were 83 patients with 110 visits with median age of 6 years. Leukemia constituted 50.6% and 92.8% was acute lymphocytic, 26.5% intracranial malignancies 59% of them posterior fossa tumors. 36.4%, presented with fever, 18% severe anemia and 16.45 % febrile neutropenia, 8% TLS (tumor lysis syndrome) and 4.5% had respiratory distress as the presentation. Presenting symptoms in 31% were neurological. 42.7% required parenteral antibiotics and 16.4% packed cell tranfusion. 90.4% of blood cultures were negative. 26.5% needed intensive care, 12 required neurosurgical procedure.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139286283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-07DOI: 10.31557/apjcc.2023.8.4.721-727
Y. R. Putra, S. Hutajulu, Susanti Susanti, D. S. Heriyanto, Naomi Yoshuantari, A. Handaya, Bambang P Utomo, Ericko Ekaputra, Mohammad Ilyas, M. Hardianti, K. W. Taroeno-Hariadi, I. Purwanto, J. Kurnianda
Introduction: Little is known about Indonesian metastatic CRC patients’ survival and prognostic factors, although this malignancy is one the most frequent cancer in the country. We aimed to investigate the survival outcome and the factors influencing local CRC patients presenting with a metastatic stage at diagnosis.Methods: A retrospective cohort study was done on 441 data of synchronous metastatic CRC cases treated between January 2016 and December 2019 at Dr. Sardjito Hospital, Yogyakarta, Indonesia. Secondary data were collected from the CRC clinical registry database. Demographic, clinicopathology and the type of treatment were collected. Survival staus was obtained from the registry database and communication to patients or caring families. Kaplan-Meier curves were used to estimate the overall survival (O.S). The Cox proportional hazards regression mode was applied to analyzethe potential factors affecting survival. Results: The median follow up of the recent study was 17 months, The median overall survival was 13 months. Two-year overall survival was 37% and the estimated 5-year overall survival was 16.1%. Multivariate cox analyses identified poor performance status (HR 2.639, 95% CI 1.438-4.842, p = 0.002), elevated carcinoembryonic antigen (CEA) (HR 2.795, 95% CI 1.509-5.176, p = 0.001) and higher histological grade (HR 2.019, 95% CI 1.112-3.667, p = 0.021) were associated with poorer overall.Conclusion: Poor performance status, high CEA level, and higher histological grade as factors that were associated with unfavourable overall survival of patients with synchronous metastatic colorectal cancer in Yogyakarta, Indonesia.
{"title":"Factors Affecting the Survival of Patients with Synchronous Metastatic Colorectal Cancer in a Tertiary Hospital in Indonesia: A Retrospective Study","authors":"Y. R. Putra, S. Hutajulu, Susanti Susanti, D. S. Heriyanto, Naomi Yoshuantari, A. Handaya, Bambang P Utomo, Ericko Ekaputra, Mohammad Ilyas, M. Hardianti, K. W. Taroeno-Hariadi, I. Purwanto, J. Kurnianda","doi":"10.31557/apjcc.2023.8.4.721-727","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.721-727","url":null,"abstract":"Introduction: Little is known about Indonesian metastatic CRC patients’ survival and prognostic factors, although this malignancy is one the most frequent cancer in the country. We aimed to investigate the survival outcome and the factors influencing local CRC patients presenting with a metastatic stage at diagnosis.Methods: A retrospective cohort study was done on 441 data of synchronous metastatic CRC cases treated between January 2016 and December 2019 at Dr. Sardjito Hospital, Yogyakarta, Indonesia. Secondary data were collected from the CRC clinical registry database. Demographic, clinicopathology and the type of treatment were collected. Survival staus was obtained from the registry database and communication to patients or caring families. Kaplan-Meier curves were used to estimate the overall survival (O.S). The Cox proportional hazards regression mode was applied to analyzethe potential factors affecting survival. Results: The median follow up of the recent study was 17 months, The median overall survival was 13 months. Two-year overall survival was 37% and the estimated 5-year overall survival was 16.1%. Multivariate cox analyses identified poor performance status (HR 2.639, 95% CI 1.438-4.842, p = 0.002), elevated carcinoembryonic antigen (CEA) (HR 2.795, 95% CI 1.509-5.176, p = 0.001) and higher histological grade (HR 2.019, 95% CI 1.112-3.667, p = 0.021) were associated with poorer overall.Conclusion: Poor performance status, high CEA level, and higher histological grade as factors that were associated with unfavourable overall survival of patients with synchronous metastatic colorectal cancer in Yogyakarta, Indonesia.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139286799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-07DOI: 10.31557/apjcc.2023.8.4.709-713
S. Bansal, Prutha Jinwala, V. Asati, Sudharani B Banappagoudar, Aditya Elhence, S. Shrivastava, R. Patidar, Pankaj Singhai, Swati Patel, P. G. Chitalkar
Objective: This study aimed to assess the palliative care knowledge among the registered nurses working in tertiary care hospital in Madhya Pradesh. Methods and materials: A prospective cross-sectional study was conducted on 160 registered nurses working in different departments in tertiary care hospital in Madhya Pradesh, who were selected through a purposive sampling technique. The data was collected through an online questionnaire for the socio-demographic variables and validated a self-report questionnaire to measure the knowledge of health care professionals in palliative care and the data was analysed by IBM-SPSSv26. Results: A total of 160 participants enrolled in the study. Basic knowledge care was quite high among the samples (83.75%). Item 1,2 of pain in palliative care was quite high (83.43%) and item 3,4,5 has (22%) only, overall management of pain knowledge was (47%) which is on the lower side. The use of Morphine was 31.04%, Dyspnoea Management it was 38.33%, and in the communication of prognosis, it was 81.56%. Resuscitation knowledge was 46.85%, Psycho spiritual was 24.06% and Bereavement care was 69%. Conclusion: One of the biggest challenges in providing excellent palliative care is that nurses don’t know enough about it. Therefore, improving the quality of palliative care services provided to patients could be accomplished by increasing their knowledge through in-service education and retraining on the job.
{"title":"Assessment of Knowledge about Palliative Care among Registered Nursing Professionals: A Prospective Cross-Sectional Study in a Tertiary Care Hospital in Central India","authors":"S. Bansal, Prutha Jinwala, V. Asati, Sudharani B Banappagoudar, Aditya Elhence, S. Shrivastava, R. Patidar, Pankaj Singhai, Swati Patel, P. G. Chitalkar","doi":"10.31557/apjcc.2023.8.4.709-713","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.709-713","url":null,"abstract":"Objective: This study aimed to assess the palliative care knowledge among the registered nurses working in tertiary care hospital in Madhya Pradesh. Methods and materials: A prospective cross-sectional study was conducted on 160 registered nurses working in different departments in tertiary care hospital in Madhya Pradesh, who were selected through a purposive sampling technique. The data was collected through an online questionnaire for the socio-demographic variables and validated a self-report questionnaire to measure the knowledge of health care professionals in palliative care and the data was analysed by IBM-SPSSv26. Results: A total of 160 participants enrolled in the study. Basic knowledge care was quite high among the samples (83.75%). Item 1,2 of pain in palliative care was quite high (83.43%) and item 3,4,5 has (22%) only, overall management of pain knowledge was (47%) which is on the lower side. The use of Morphine was 31.04%, Dyspnoea Management it was 38.33%, and in the communication of prognosis, it was 81.56%. Resuscitation knowledge was 46.85%, Psycho spiritual was 24.06% and Bereavement care was 69%. Conclusion: One of the biggest challenges in providing excellent palliative care is that nurses don’t know enough about it. Therefore, improving the quality of palliative care services provided to patients could be accomplished by increasing their knowledge through in-service education and retraining on the job.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"147 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139286918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-07DOI: 10.31557/apjcc.2023.8.4.715-719
Abhinandan Das, A. Kalita, M. Bhattacharyya, J. Nath, Yanpothung Yanthan, T. Das, Ankita Das, Moniprom Neog, Mongal Sonar
Background: Esophageal cancer is a highly aggressive malignancy often associated with a poor prognosis because of locoregional failure and distant metastases. About 60–70 percent of the patients present at an advanced stage, have a median survival in the range of 6-10 months, and are not amenable to definitive treatment. Dysphagia is the most common complaint, seen in 80%–90% of patients. The priority for managing patients with advanced disease is dysphagia control, which in turn can improve nutritional intake and quality of life. External-beam radiotherapy (EBRT) is one of the major means of palliation. Objective: The primary goal of our study was to assess the efficacy of external beam radiotherapy in alleviating dysphagia in patients with esophageal cancer.Materials and method: This was a single arm prospective clinical study conducted in a tertiary care hospital in northeast India. The study comprised of 57 esophageal cancer patients, ineligible for definitive treatment. The patients received EBRT of 30 Gy in 10 fractions over two weeks. Dysphagia was graded using Modified Takita’s grading system. Patients were followed up at one-month intervals after treatment to assess dysphagia and acute toxicity. Results: Out of 57 patients in the study, subjective dysphagia relief was seen in 82.45%. The median dysphagia score decreased from 3 to 2 at the end of the 3-month post treatment period. (p < .001). In terms of treatment-related toxicity, treatment was well tolerated. No grade 4-5 toxicity was encountered. The most commonly encountered toxicity was radiation esophagitis, which affected 15 patients (26.31%).Conclusion: Radiation significantly improves dysphagia in esophageal cancer patients. It is an effective, non-invasive, and well-tolerated way to treat dysphagia in selected individuals with incurable esophageal cancer.
{"title":"External Beam Radiotherapy for Dysphagia Palliation in Advanced Esophageal Cancer: A Prospective Study","authors":"Abhinandan Das, A. Kalita, M. Bhattacharyya, J. Nath, Yanpothung Yanthan, T. Das, Ankita Das, Moniprom Neog, Mongal Sonar","doi":"10.31557/apjcc.2023.8.4.715-719","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.715-719","url":null,"abstract":"Background: Esophageal cancer is a highly aggressive malignancy often associated with a poor prognosis because of locoregional failure and distant metastases. About 60–70 percent of the patients present at an advanced stage, have a median survival in the range of 6-10 months, and are not amenable to definitive treatment. Dysphagia is the most common complaint, seen in 80%–90% of patients. The priority for managing patients with advanced disease is dysphagia control, which in turn can improve nutritional intake and quality of life. External-beam radiotherapy (EBRT) is one of the major means of palliation. Objective: The primary goal of our study was to assess the efficacy of external beam radiotherapy in alleviating dysphagia in patients with esophageal cancer.Materials and method: This was a single arm prospective clinical study conducted in a tertiary care hospital in northeast India. The study comprised of 57 esophageal cancer patients, ineligible for definitive treatment. The patients received EBRT of 30 Gy in 10 fractions over two weeks. Dysphagia was graded using Modified Takita’s grading system. Patients were followed up at one-month intervals after treatment to assess dysphagia and acute toxicity. Results: Out of 57 patients in the study, subjective dysphagia relief was seen in 82.45%. The median dysphagia score decreased from 3 to 2 at the end of the 3-month post treatment period. (p < .001). In terms of treatment-related toxicity, treatment was well tolerated. No grade 4-5 toxicity was encountered. The most commonly encountered toxicity was radiation esophagitis, which affected 15 patients (26.31%).Conclusion: Radiation significantly improves dysphagia in esophageal cancer patients. It is an effective, non-invasive, and well-tolerated way to treat dysphagia in selected individuals with incurable esophageal cancer.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139284642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.855-860
Sunil Kumar Yadav Y, Rohit Desai, Pranav Sopory, Femina Dawer, Rajan Mittal, Kumar Gaurav, Rahul Rathod, Akhila Paspulate
Objective: Out of all newly diagnosed colorectal cancer cases globally, 20% of the patients present with metastasis, and 25% develop metastasis later. The 5-year survival rate after diagnosis for mCRC patients is <20%. Although many studies using population-based cancer registries from India are available on various cancers, data on mCRC in India is scarce. Therefore, the purpose of the ReCoRD registry is to obtain real world data on demographics, treatment pattern and outcomes in Indian patients with mCRC. Methods: This is a prospective, multicenter, observational study on 1000 participants with mCRC, who are enrolled in the registry in up to 15 centers for 2 years. The recruitment will be stopped 2 years following the first patient enrollment. A minimum follow-up of 12–18 months is being carried out post-enrollment in the registry. Data on the demography, clinical features, molecular profile, treatment options, and outcomes of treatment for these patients is being collected from the study sites by investigators. The Kaplan-Meier Plot will be utilized to examine the survival data, and the median time computed by the Kaplan-Meier technique will be presented with a confidence interval of 95%.Conclusion: Although mCRC remains incurable in most cases, survival rates have improved with the advent of newer cytotoxic chemotherapeutic drugs and targeted agents. The ReCoRD registry will collect details of the demography, tumor characteristics, molecular aspects, treatment, and treatment outcomes in individuals with mCRC, which can guide the clinicians in decision making and treatment based on Indian patient data.
{"title":"A Prospective, Multicenter, Observational Registry (ReCoRD) on Demography, Molecular Profile, Clinical Features, and Treatment Outcomes in Individuals undergoing Treatment for Metastatic Colorectal Cancer","authors":"Sunil Kumar Yadav Y, Rohit Desai, Pranav Sopory, Femina Dawer, Rajan Mittal, Kumar Gaurav, Rahul Rathod, Akhila Paspulate","doi":"10.31557/apjcc.2023.8.4.855-860","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.855-860","url":null,"abstract":"Objective: Out of all newly diagnosed colorectal cancer cases globally, 20% of the patients present with metastasis, and 25% develop metastasis later. The 5-year survival rate after diagnosis for mCRC patients is <20%. Although many studies using population-based cancer registries from India are available on various cancers, data on mCRC in India is scarce. Therefore, the purpose of the ReCoRD registry is to obtain real world data on demographics, treatment pattern and outcomes in Indian patients with mCRC. Methods: This is a prospective, multicenter, observational study on 1000 participants with mCRC, who are enrolled in the registry in up to 15 centers for 2 years. The recruitment will be stopped 2 years following the first patient enrollment. A minimum follow-up of 12–18 months is being carried out post-enrollment in the registry. Data on the demography, clinical features, molecular profile, treatment options, and outcomes of treatment for these patients is being collected from the study sites by investigators. The Kaplan-Meier Plot will be utilized to examine the survival data, and the median time computed by the Kaplan-Meier technique will be presented with a confidence interval of 95%.Conclusion: Although mCRC remains incurable in most cases, survival rates have improved with the advent of newer cytotoxic chemotherapeutic drugs and targeted agents. The ReCoRD registry will collect details of the demography, tumor characteristics, molecular aspects, treatment, and treatment outcomes in individuals with mCRC, which can guide the clinicians in decision making and treatment based on Indian patient data.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.675-679
Apoorva Dadheech, Suman Kumawat, Deepesh Sharma, Ravinder Singh Gothwal, R. Dana, Chetna Meena, Naresh Kumar Saini
Introduction: Being diagnosed with breast cancer or receiving surgery, radiation or chemotherapy as a treatment modality in itself is seen as a traumatic experience for many women. This emotional distress is in turn associated with reduced quality of life and can pose a negative influence on compliance with treatment. Ultimately leading to an elevated risk of mortality which is also seen as the sixth vital sign in cancer care.Aim & Objectives: The purpose of our study is to estimate the prevalence of depression and anxiety in breast cancer patients and their correlation with socio-demographic factors. Materials and Methods: A cohort of 140 breast cancer patients registered in the Department of Radiation Oncology, SMS medical College, Jaipur from January 2022 to December 2022 were recruited and interviewed with a structured questionnaire including socio-clinical and demographic factors and PHQ-2 and GAD-2 scales. Results: Prevalence of depression among patients were 37.9% (53/140) and almost one third (33.6%, 47/140) of cases had anxiety. Around two thirds (69.3%, 97/140) cases had stage III breast cancer, followed by stage II in 23 (16.4%) cases and 20 (14.3%) cases had IV stage breast cancer. The place of residence, educational status, employment status, accompanying person and marital status emerged as significant predictors of depression risk, while age group, marital status and financial status were found to have statistically significant association with elevated anxiety symptoms.Conclusion: This study shows that prevalence of anxiety and depression in breast cancer patients is high and patients from rural areas, single, low monthly income, younger age group and low education level were more prone. Therefore, special care and support and often referral to psychiatry department may be required in such group of patients.
{"title":"The Prevalence of Anxiety and Depression in Breast Cancer Patients and their Correlation with Socio-Demographic Factors","authors":"Apoorva Dadheech, Suman Kumawat, Deepesh Sharma, Ravinder Singh Gothwal, R. Dana, Chetna Meena, Naresh Kumar Saini","doi":"10.31557/apjcc.2023.8.4.675-679","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.675-679","url":null,"abstract":"Introduction: Being diagnosed with breast cancer or receiving surgery, radiation or chemotherapy as a treatment modality in itself is seen as a traumatic experience for many women. This emotional distress is in turn associated with reduced quality of life and can pose a negative influence on compliance with treatment. Ultimately leading to an elevated risk of mortality which is also seen as the sixth vital sign in cancer care.Aim & Objectives: The purpose of our study is to estimate the prevalence of depression and anxiety in breast cancer patients and their correlation with socio-demographic factors. Materials and Methods: A cohort of 140 breast cancer patients registered in the Department of Radiation Oncology, SMS medical College, Jaipur from January 2022 to December 2022 were recruited and interviewed with a structured questionnaire including socio-clinical and demographic factors and PHQ-2 and GAD-2 scales. Results: Prevalence of depression among patients were 37.9% (53/140) and almost one third (33.6%, 47/140) of cases had anxiety. Around two thirds (69.3%, 97/140) cases had stage III breast cancer, followed by stage II in 23 (16.4%) cases and 20 (14.3%) cases had IV stage breast cancer. The place of residence, educational status, employment status, accompanying person and marital status emerged as significant predictors of depression risk, while age group, marital status and financial status were found to have statistically significant association with elevated anxiety symptoms.Conclusion: This study shows that prevalence of anxiety and depression in breast cancer patients is high and patients from rural areas, single, low monthly income, younger age group and low education level were more prone. Therefore, special care and support and often referral to psychiatry department may be required in such group of patients.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"203 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.703-708
Ahmed Mjali, Abdulrazzak Kalaf Hassan, H. A. Nassrullah, A. Sedeeq, N. Abbas, H. Al-Shammari, A. F. Alwakeel, Bahaa Mjali
Background: Head and neck cancers (HNCs) patterns vary worldwide in relation to demographic and environmental factors. Objective: The aim of our study was to investigate the pattern of HNCs in Karbala province of Iraq, compare and identify possible changes with other populations.Methods: A retrospective descriptive study was carried out at Al-Hussein Cancer Center in Karbala, Iraq, on 302 patients diagnosed with HNCs between January 2012 and December 2021 with evaluation of age, gender distribution and sites of cancers.Results: Among total 302 patients, median age was 58 years. Males accounted for a higher proportion of patients, (67.55%) were males and (32.45%) were females, with an M:F ratio of 2.08:1. Larynx was the most affected site among our patients contributing (28.48%) followed by nasopharynx (28.14%), lip & oral cavity (14.57%), salivary glands (11.59%), oropharynx (8.28%), paranasal sinuses (5.30%) and hypopharynx (3.64%). The most frequent site of HNCs in males was larynx, while the most frequent site in females was nasopharynx. Conclusion: This is the first statistical study of HNCs in Karbala province of Iraq. It can be used as basic information to investigate epidemiological characteristics, to evaluate progress in recent years and to develop treatment strategies.
{"title":"Pattern of Head and Neck Cancers in Karbala Province of Iraq: Data from Developing Country","authors":"Ahmed Mjali, Abdulrazzak Kalaf Hassan, H. A. Nassrullah, A. Sedeeq, N. Abbas, H. Al-Shammari, A. F. Alwakeel, Bahaa Mjali","doi":"10.31557/apjcc.2023.8.4.703-708","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.703-708","url":null,"abstract":"Background: Head and neck cancers (HNCs) patterns vary worldwide in relation to demographic and environmental factors. Objective: The aim of our study was to investigate the pattern of HNCs in Karbala province of Iraq, compare and identify possible changes with other populations.Methods: A retrospective descriptive study was carried out at Al-Hussein Cancer Center in Karbala, Iraq, on 302 patients diagnosed with HNCs between January 2012 and December 2021 with evaluation of age, gender distribution and sites of cancers.Results: Among total 302 patients, median age was 58 years. Males accounted for a higher proportion of patients, (67.55%) were males and (32.45%) were females, with an M:F ratio of 2.08:1. Larynx was the most affected site among our patients contributing (28.48%) followed by nasopharynx (28.14%), lip & oral cavity (14.57%), salivary glands (11.59%), oropharynx (8.28%), paranasal sinuses (5.30%) and hypopharynx (3.64%). The most frequent site of HNCs in males was larynx, while the most frequent site in females was nasopharynx. Conclusion: This is the first statistical study of HNCs in Karbala province of Iraq. It can be used as basic information to investigate epidemiological characteristics, to evaluate progress in recent years and to develop treatment strategies.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-21DOI: 10.31557/apjcc.2023.8.4.779-781
Laurence Vaitiekunas, Susan Caird, David Eriksen
Background: Malignant obstructive jaundice is associated with a poor prognosis. Patients can undergo percutaneous transhepatic biliary drainage (PTBD), but the impact it has on quality of life is not well understood.Objective: To assess the potential impact of PTBD on quality of life in patients with obstructive jaundice from advanced malignancy using surrogate markers including complications, hospital length of stay, readmission, reintervention, and mortality. Methods: A retrospective analysis of a single-centre cohort of all patients with advanced solid organ malignancy undergoing PTBD between April 2020 and February 2022. Data was collected from electronic medical records.Results: Among the sixteen patients, abdominal pain and cholangitis were observed in 62.5% and 37.5% patients, respectively. Peritonitis, biliary leak, perihepatic abscess, and haemobilia occurred in individual cases. The median hospital length of stay post PTBD was nine days. The 30-day readmission rate for PTBD-related complications was 31.3% with a median of three total readmissions per patient. The 30-day reintervention rate was 62.5%. The 30-day all-cause mortality was 25% (95% CI:8.9-53.3), which included one procedure-related death. Conclusions: Quality of life in patients with obstructive jaundice from advanced solid organ malignancy undergoing PTBD can be adversely impacted due to the high risk of complications, reintervention, hospitalisation, and mortality. Thorough patient assessments are crucial in selecting appropriate candidates for PTBD.
{"title":"Percutaneous Transhepatic Biliary Drainage for Malignant Biliary Obstruction in Advanced Solid Organ Malignancy: Clinical Outcomes and a Perspective on Quality of Life","authors":"Laurence Vaitiekunas, Susan Caird, David Eriksen","doi":"10.31557/apjcc.2023.8.4.779-781","DOIUrl":"https://doi.org/10.31557/apjcc.2023.8.4.779-781","url":null,"abstract":"Background: Malignant obstructive jaundice is associated with a poor prognosis. Patients can undergo percutaneous transhepatic biliary drainage (PTBD), but the impact it has on quality of life is not well understood.Objective: To assess the potential impact of PTBD on quality of life in patients with obstructive jaundice from advanced malignancy using surrogate markers including complications, hospital length of stay, readmission, reintervention, and mortality. Methods: A retrospective analysis of a single-centre cohort of all patients with advanced solid organ malignancy undergoing PTBD between April 2020 and February 2022. Data was collected from electronic medical records.Results: Among the sixteen patients, abdominal pain and cholangitis were observed in 62.5% and 37.5% patients, respectively. Peritonitis, biliary leak, perihepatic abscess, and haemobilia occurred in individual cases. The median hospital length of stay post PTBD was nine days. The 30-day readmission rate for PTBD-related complications was 31.3% with a median of three total readmissions per patient. The 30-day reintervention rate was 62.5%. The 30-day all-cause mortality was 25% (95% CI:8.9-53.3), which included one procedure-related death. Conclusions: Quality of life in patients with obstructive jaundice from advanced solid organ malignancy undergoing PTBD can be adversely impacted due to the high risk of complications, reintervention, hospitalisation, and mortality. Thorough patient assessments are crucial in selecting appropriate candidates for PTBD.","PeriodicalId":502165,"journal":{"name":"Asian Pacific Journal of Cancer Care","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139315747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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