Notes on Fenbendazole resistance of Boer goats in a farm in Setiu, Terengganu

Nur Nadirah Abdul Halim, Ahmad Syazni Kamarudin
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Abstract

Gastrointestinal parasitic infection is a serious threat to small ruminant industry. The control of helminth infection in goat are heavily relied on anthelmintic drugs. However, anthelmintic resistance has emerged as a big threat to the farmers and ruminant industry. Anthelmintic resistance against commonly used anthelmintic; Fenbendazole, was evaluated by using Faecal Egg Count Reduction Test (FECRT) of gastrointestinal (GI) parasites in a farm located in Setiu, Terengganu. GI parasites screening were carried out and a total of 28 animals with high parasites infection (EPG > 1000) were selected and divided into two groups (n= 14, Control vs Treatment). The Treatment group were administered with Fenbendazole (0.1ml/kg body weight) while Control group were leave untreated. Mean percentage reduction of FEC (95% upper and lower confidence limits) for the Treatment group are 32.75 (100 and -83) indicating resistant towards Fenbendazole treatment. The farm is recommended to use and alternate another group of anthelminthic drugs to treat their animals.
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关于丁加奴省塞提乌农场波尔山羊苯菌灵抗药性的说明
胃肠道寄生虫感染是对小型反刍动物产业的严重威胁。山羊蠕虫感染的控制主要依靠抗蠕虫药物。然而,抗寄生虫药物的抗药性已经成为农民和反刍动物业的一大威胁。在登嘉楼省塞提乌市的一个农场中,通过粪便卵数还原试验(FECRT)对胃肠道寄生虫(GI)进行了评估,结果表明对常用驱虫药苯苯咪唑(Fenbendazole)产生了抗药性。进行了胃肠道寄生虫筛查,共挑选了 28 只寄生虫感染率较高(EPG > 1000)的动物,并将其分为两组(n= 14,对照组与治疗组)。治疗组使用苯醚甲环唑(0.1 毫升/千克体重),而对照组则不使用苯醚甲环唑。治疗组的 FEC 平均减少百分比(95% 置信上限和下限)为 32.75(100 和 -83),表明对芬苯达唑治疗产生抗药性。建议该农场交替使用另一类抗蠕虫药物治疗动物。
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