Evaluation of Oral Preparations of Vitamin E as Antioxidant Using DPPH Method (Diphenyl picrylhydrazyl)

Berkala Ilmiah Kimia Farmasi Pub Date : 2023-06-30 DOI:10.20473/bikfar.v10i1.47115

Broto Anung Laksono, Nawal Ariqoh, Rif’at, Tsabitah ‘Afiy, Arsyah, Erlisa Alya Hanifah, Evi, Wiela Astuti, Happy Rizki Rakhmawati, Clarisa Dian Cahyani, Hanun Najwa, Ariesta Yusuf Adyatama, Dena Septiyani, Zabrina Izatti Rachman, Agda Rismafuri, Mukti Kirana, Achmad Toto, Purnomo, Retno Sari

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Abstract

This article aimed to evaluate the activity of Vitamin E as an antioxidant in oral pharmaceutical preparations. Vitamin E is an essential nutrition soluble in fat that has the pharmacology effect as an antioxidant. Vitamin E consists of α, β, γ, δ-tocopherol and α, β, γ, δ-tocotrienol. The activity of vitamin E was observed for its ability to inhibit reduction using the DPPH method. The antioxidant activity is calculated as an inhibition concentration of 50% (IC50) which is the concentration of a sample that can reduce 50% of DPPH. It was known that IC50 of vitamin E was very strong with value of 42.86%. Based on the article review, it can be concluded that the activity of Vitamin E as an antioxidant in oral pharmaceutical preparations was very high and strong. Keywords: Vitamin E, alpha-tocopherol, antioxidant, activity, IC50, oral pharmaceutical preparations

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用 DPPH 法（二苯基吡啶肼）评估维生素 E 口服制剂的抗氧化性

本文旨在评估维生素 E 在口服药物制剂中作为抗氧化剂的活性。维生素 E 是一种可溶于脂肪的必需营养物质，具有抗氧化剂的药理作用。维生素 E 由 α、β、γ、δ-生育酚和α、β、γ、δ-生育三烯酚组成。维生素 E 的活性是通过 DPPH 法观察其抑制还原的能力。抗氧化活性是以 50%的抑制浓度（IC50）来计算的，即样品能减少 50%的 DPPH 的浓度。据了解，维生素 E 的 IC50 值为 42.86%，非常强大。根据文章综述，可以得出结论：维生素 E 作为一种抗氧化剂，在口服药物制剂中的活性非常高且强。关键词：维生素 E维生素 E、α-生育酚、抗氧化剂、活性、IC50、口服药物制剂

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