Liliana Maria Dimer , Tamy Colonetti , Maria Laura Rodrigues Uggioni , Sarah Dagostin Ferraz , Antonio José Grande , Maria Inês Rosa , Luciane Bisognin Ceretta
{"title":"Evaluation of the effects of Bauhinia forficata as an adjuvant in the treatment of type 2 diabetes mellitus: Systematic review and meta-analysis","authors":"Liliana Maria Dimer , Tamy Colonetti , Maria Laura Rodrigues Uggioni , Sarah Dagostin Ferraz , Antonio José Grande , Maria Inês Rosa , Luciane Bisognin Ceretta","doi":"10.1016/j.eujim.2024.102331","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin action and secretion. <em>Bauhinia forficata</em> has been observed to exhibit an effect in diabetes treatment due to its hypoglycemic activity. This systematic review with meta-analysis aimed to assess the effects of using <em>Bauhinia forficata</em> as an adjuvant treatment for individuals with T2DM.</p></div><div><h3>Methods</h3><p>We conducted a comprehensive search strategy using relevant keywords and their synonyms, focusing on \"<em>Bauhinia forficata</em>\" and \"diabetes mellitus.\" The search encompassed online databases such as Medline, Embase via OVID, and the Cochrane Library, without imposing language restrictions. We included studies that evaluated individuals diagnosed with T2DM, who were administered <em>Bauhinia forficata,</em> compared to placebo or active control, and who presented glycemia and glycated hemoglobin as outcome measures. Studies not meeting these criteria, as well as literature reviews, animal or in vitro experiments, were excluded. The methodological quality of the included studies was assessed using the Risk of Bias 2 tool. The results were presented through tables and graphs, and forest plots were generated to illustrate the effects of interventions on various outcomes, using RevMan software 5.4.</p></div><div><h3>Results</h3><p>Four studies met the inclusion criteria, comprising two randomized controlled trials (RCT) and two non-randomized studies of interventions (NRSI). Compared to placebo, <em>Bauhinia forficata</em> significantly improved glycemia (SMD -0.60, 95 % CI -0.15 to -1.05, <em>p</em> = 0.009, 1 RCT, <em>n</em> = 111, low certainty evidence; SMD -0.64, 95 % CI -1.25 to -0.03, <em>p</em> = 0.04, I²=42 %, 2 NSRIs pre-test/post-test, <em>n</em> = 40, very low certainty evidence). However, only the RCT evidence demonstrated significant improvements in HbA1c (SMD -0.48, 95 % CI -0.93, <em>p</em> = 0.03, 1 RCT, <em>n</em> = 111, low certainty evidence; SMD -0.25, 95 %CI -0.69 to 0.19, <em>p</em>-0.27, I²=0 %, 2 NSRIs pretest/post-test, <em>n</em> = 40, very low certainty evidence). No differences were found between <em>Bauhinia forficata</em> and <em>Imperata brasiliensis</em> (glycemia SMD -0.03, 95 % CI -1.01 to 0.95, <em>p</em> = 0.96, 1 RCT, <em>n</em> = 16, very low certainty evidence; HbA1c SMD 0.06, 95 % CI -0.92 to 1.04, <em>p</em> = 0.96, 1 RCT, <em>n</em> = 16, very low certainty evidence).</p></div><div><h3>Conclusions</h3><p>The findings suggest that <em>Bauhinia forficata</em> may be effective in reducing blood glucose levels; however, this evidence needs to be interpreted with caution.</p></div><div><h3>PROSPERO registration</h3><p>CRD42022370143.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"65 ","pages":"Article 102331"},"PeriodicalIF":1.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Integrative Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876382024000027","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin action and secretion. Bauhinia forficata has been observed to exhibit an effect in diabetes treatment due to its hypoglycemic activity. This systematic review with meta-analysis aimed to assess the effects of using Bauhinia forficata as an adjuvant treatment for individuals with T2DM.
Methods
We conducted a comprehensive search strategy using relevant keywords and their synonyms, focusing on "Bauhinia forficata" and "diabetes mellitus." The search encompassed online databases such as Medline, Embase via OVID, and the Cochrane Library, without imposing language restrictions. We included studies that evaluated individuals diagnosed with T2DM, who were administered Bauhinia forficata, compared to placebo or active control, and who presented glycemia and glycated hemoglobin as outcome measures. Studies not meeting these criteria, as well as literature reviews, animal or in vitro experiments, were excluded. The methodological quality of the included studies was assessed using the Risk of Bias 2 tool. The results were presented through tables and graphs, and forest plots were generated to illustrate the effects of interventions on various outcomes, using RevMan software 5.4.
Results
Four studies met the inclusion criteria, comprising two randomized controlled trials (RCT) and two non-randomized studies of interventions (NRSI). Compared to placebo, Bauhinia forficata significantly improved glycemia (SMD -0.60, 95 % CI -0.15 to -1.05, p = 0.009, 1 RCT, n = 111, low certainty evidence; SMD -0.64, 95 % CI -1.25 to -0.03, p = 0.04, I²=42 %, 2 NSRIs pre-test/post-test, n = 40, very low certainty evidence). However, only the RCT evidence demonstrated significant improvements in HbA1c (SMD -0.48, 95 % CI -0.93, p = 0.03, 1 RCT, n = 111, low certainty evidence; SMD -0.25, 95 %CI -0.69 to 0.19, p-0.27, I²=0 %, 2 NSRIs pretest/post-test, n = 40, very low certainty evidence). No differences were found between Bauhinia forficata and Imperata brasiliensis (glycemia SMD -0.03, 95 % CI -1.01 to 0.95, p = 0.96, 1 RCT, n = 16, very low certainty evidence; HbA1c SMD 0.06, 95 % CI -0.92 to 1.04, p = 0.96, 1 RCT, n = 16, very low certainty evidence).
Conclusions
The findings suggest that Bauhinia forficata may be effective in reducing blood glucose levels; however, this evidence needs to be interpreted with caution.
期刊介绍:
The European Journal of Integrative Medicine (EuJIM) considers manuscripts from a wide range of complementary and integrative health care disciplines, with a particular focus on whole systems approaches, public health, self management and traditional medical systems. The journal strives to connect conventional medicine and evidence based complementary medicine. We encourage submissions reporting research with relevance for integrative clinical practice and interprofessional education.
EuJIM aims to be of interest to both conventional and integrative audiences, including healthcare practitioners, researchers, health care organisations, educationalists, and all those who seek objective and critical information on integrative medicine. To achieve this aim EuJIM provides an innovative international and interdisciplinary platform linking researchers and clinicians.
The journal focuses primarily on original research articles including systematic reviews, randomized controlled trials, other clinical studies, qualitative, observational and epidemiological studies. In addition we welcome short reviews, opinion articles and contributions relating to health services and policy, health economics and psychology.