Antioxidant defense of children and adolescents with atopic dermatitis: Association with disease severity.

IF 2.5 4区医学 Q3 ALLERGY Allergologia et immunopathologia Pub Date : 2024-01-01 DOI:10.15586/aei.v52i1.933

Roseani da Silva Andrade, Fabíola Isabel Suano de Souza, Carolina Sanchez Aranda, Marcia Carvalho Mallozi, Ariel Cordeiro Ferreira, Talita Lemos Neves Barreto, Fernando Luiz Affonso Fonseca, Roseli Oselka Saccardo Sarni, Dirceu Solé

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Abstract

Background: Atopic dermatitis (AD) is a relapsing, chronic cutaneous inflammatory disease with onset, in general, in early childhood. Chronic skin inflammation is associated with overproduction of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. Oxidative stress, an imbalance between the production of free radicals and antioxidant defense, results in tissue inflammation due to the upregulation of genes that encode inflammatory cytokines. This condition plays an important role in the pathogenesis of AD.

Objective: To compare the antioxidant defense in children and adolescents with AD with that of healthy individuals and to verify the association of antioxidant defense with disease severity and nutritional status.

Methods: Cross-sectional study that evaluated 48 children and adolescents with AD and 25 controls for nutritional assessment (body mass index z score [BMIZ] and height for age z score [HAZ]) and levels of vitamins A, C, E, and D, zinc (Zn), copper (Cu), antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx]), high-sensitivity C-reactive protein (CRP) and interleukin 33 (IL-33).

Results: There was no significant difference in the comparison between AD and control groups for serum levels of vitamins (A, D, C, and E), copper, and antioxidant enzymes. Serum zinc levels were higher in the AD group (β = 24.20; 95% CI 13.95-34.91; P < 0.001) even after adjusting the BMIZ, HAZ, gender, IL-33, and CRP. Children and adolescents with moderate or severe AD compared to mild AD (SCORAD - 36.7±17.4 vs 11.8 ± 3.9; P < 0.001) had lower values of the vitamin E/total lipid ratio (3.68 [0.29;12.63] vs 5.92 [3.27;17.37]; P = 0.013).

Conclusion: Children and adolescents with AD had higher concentrations OF elevated levels of zinc compared to controls, a fact not observed for other biomarkers of antioxidant defense. AD in moderate or severe forms presented lower concentrations of vitamin E, a potent antioxidant fat soluble.

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特应性皮炎儿童和青少年的抗氧化防御能力：与疾病严重程度的关系

背景：特应性皮炎（AD）是一种复发性慢性皮肤炎症性疾病，一般在儿童早期发病。慢性皮肤炎症与过量产生活性氧（ROS）（如超氧化物和过氧化氢）有关。氧化应激是自由基的产生与抗氧化防御之间的失衡，由于编码炎症细胞因子的基因上调，导致组织炎症。这种情况在注意力缺失症的发病机制中起着重要作用：比较患有 AD 的儿童和青少年与健康人的抗氧化防御能力，并验证抗氧化防御能力与疾病严重程度和营养状况的关系：横断面研究：对48名患有AD的儿童和青少年以及25名对照组进行营养评估（体重指数z评分[BMIZ]和年龄身高z评分[HAZ]），并评估维生素A、C、E和D、锌（Zn）、铜（Cu）、抗氧化酶（超氧化物歧化酶[SOD]、过氧化氢酶[CAT]、谷胱甘肽过氧化物酶[GPx]）、高敏C反应蛋白（CRP）和白细胞介素33（IL-33）的水平。结果AD组和对照组的血清维生素（A、D、C和E）、铜和抗氧化酶水平比较无明显差异。即使调整了BMIZ、HAZ、性别、IL-33和CRP，AD组的血清锌水平也更高（β = 24.20; 95% CI 13.95-34.91; P < 0.001）。与轻度AD（SCORAD - 36.7±17.4 vs 11.8±3.9；P <0.001）相比，中度或重度AD儿童和青少年的维生素E/总脂质比值较低（3.68 [0.29;12.63] vs 5.92 [3.27;17.37]；P = 0.013）：结论：与对照组相比，患有注意力缺失症的儿童和青少年体内锌的浓度更高，而在其他抗氧化防御生物标志物中却没有发现这一现象。中度或重度AD患者的维生素E浓度较低，而维生素E是一种有效的脂溶性抗氧化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.