Association between p73 RS2273953 to RS1801173 polymorphism and risk of lung cancer: a meta-analysis of 2,897 cases and 3,317 controls.

IF 1.1 Q4 ONCOLOGY International journal of clinical and experimental pathology Pub Date : 2023-12-15 eCollection Date: 2023-01-01

Xu Li, Zaiqiang Guo, Chengwei Zhang, Ying Xiong, Chunxia Ding, Ke Wei, Xiaohong Dai, Hui Dai, Yonghuai Ma, Fangcai Lin

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Abstract

Background: Lung cancer is one of the most common and deadly cancers in humans. P73, a member of the p53 family, is a vital gene for the carcinogenesis of lung cancer. Single nucleotide polymorphism (SNP) of P73 gene may affect the risk of lung cancer. Therefore, we performed a meta-analysis of p73 SNP and lung cancer risk using the most recent data.

Methods: A total of 1407 articles from EMBASE, Web of science, PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were identified initially from the search. A meta-analysis of the association between P73 polymorphism and lung cancer risk was performed based on various genetic models and by type of lung cancer and race.

Results: Seven articles published in either English or Chinese with English abstract were eventually selected for final analysis. The total pooled population included 6214 subjects (2,897 cases and 3,317 controls). The results showed that p73 RS2273953 to RS1801173 polymorphism was associated with increased risk of lung cancer in Caucasians but not in Asians. Within Asians, those with p73 GC/GC may have an increased risk for squamous carcinoma compared to those with GC/AT+AT/AT polymorphism.

Conclusions: Our analysis suggested a lack of association between p73 RS2273953 to RS1801173 polymorphism and risk of lung cancer overall. However, patients with GC/GC polymorphism showed an increased risk for squamous carcinoma in the lung compared to those with GC/AT+AT/AT in Asians.

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p73 RS2273953 至 RS1801173 多态性与肺癌风险的关系：对 2,897 例病例和 3,317 例对照的荟萃分析。

背景：肺癌是人类最常见、最致命的癌症之一：肺癌是人类最常见、最致命的癌症之一。P73 是 p53 家族的成员，是肺癌发生的重要基因。P73 基因的单核苷酸多态性（SNP）可能会影响肺癌的发病风险。因此，我们利用最新数据对 P73 SNP 与肺癌风险进行了荟萃分析：方法：我们从 EMBASE、Web of science、PubMed 和中国国家知识基础设施（CNKI）数据库中检索到了共计 1407 篇文章。根据不同的遗传模型以及肺癌类型和种族，对P73多态性与肺癌风险之间的关系进行了荟萃分析：最终选择了 7 篇以英文或中文发表并附有英文摘要的文章进行最终分析。汇总人群包括 6214 名受试者（2897 例病例和 3317 例对照）。结果显示，p73 RS2273953 至 RS1801173 多态性与白种人肺癌风险增加有关，但与亚洲人无关。在亚洲人中，与具有 GC/AT+AT/AT 多态性的人相比，具有 p73 GC/GC 多态性的人罹患鳞癌的风险可能更高：我们的分析表明，p73 RS2273953 至 RS1801173 多态性与罹患肺癌的总体风险没有关联。然而，在亚洲人中，与GC/AT+AT/AT多态性患者相比，GC/GC多态性患者罹患肺鳞癌的风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of clinical and experimental pathology ONCOLOGY-PATHOLOGY

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1 months

期刊介绍： The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.