Bibliometric analysis of the inflammatory mechanisms in knee osteoarthritis in recent 30 years.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2023-12-15 eCollection Date: 2023-01-01
Yiyi Chen, Bo Yu, Fei He, Wenjiang Sun, Yuting Song
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Abstract

This study aimed to improve Knee Osteoarthritis (KOA) therapy by evaluating the knowledge framework and investigating research trends in inflammatory mechanisms. Conducting a thorough search on July 31, 2023, using the Science Citation Index Expanded of the Web of Science Core Collection, we identified 1,083 articles authored by 6,159 individuals from 3,610 institutions across 299 countries. China led in productivity with 377 papers, followed by the United States (253) and Japan (60). The University of California System (20 publications), Guangzhou University of Science and Technology (19), Duke University (18), and Shanghai Jiao Tong University (18) were the top institutions. Notably, the USA and Southern Medical University China held significant centrality in countries and institutions, respectively. Among 1,084 co-occurring keywords, "expression", "rheumatoid arthritis", "articular cartilage", "F kappa b", and "Synovial fluid" emerged as highly correlated topics. Analyzing inflammatory mechanisms in KOA through visualization tools offers insights into the knowledge framework, aiding in identifying future trends for better pain control. The study employed CiteSpace, VOS Viewer, and Tableau to analyze research hotspots and frontiers in inflammation mechanisms in KOA. It focused on essential signaling pathways in articular cartilage, synovial membrane, subchondral bone, and synovial fluids of OA patients and animal models, along with potential therapeutic reagents. Future exploration of the interaction between mechanisms can elucidate key factors in different pathways and the efficacy of injection therapy on inflammation.

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近30年来膝关节骨关节炎炎症机制的文献计量分析。
本研究旨在通过评估知识框架和调查炎症机制的研究趋势来改进膝骨关节炎(KOA)的治疗。2023 年 7 月 31 日,我们使用科学网核心数据库的科学引文索引扩展版进行了全面检索,共发现了 299 个国家 3,610 个机构的 6,159 位学者撰写的 1,083 篇文章。中国以 377 篇论文居首,其次是美国(253 篇)和日本(60 篇)。发表论文最多的机构是加州大学系统(20 篇)、广州科技大学(19 篇)、杜克大学(18 篇)和上海交通大学(18 篇)。值得注意的是,美国和中国南方医科大学分别在国家和机构中占据重要位置。在 1084 个共同出现的关键词中,"表达"、"类风湿性关节炎"、"关节软骨"、"F kappa b "和 "滑膜液 "成为高度相关的主题。通过可视化工具分析 KOA 中的炎症机制,可以深入了解知识框架,有助于确定未来趋势,从而更好地控制疼痛。该研究利用 CiteSpace、VOS Viewer 和 Tableau 分析了 KOA 中炎症机制的研究热点和前沿。研究重点关注 OA 患者和动物模型的关节软骨、滑膜、软骨下骨和滑液中的重要信号通路,以及潜在的治疗试剂。未来对各种机制之间相互作用的探索可以阐明不同途径中的关键因素以及注射疗法对炎症的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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