The effects of high and low dose extracorporeal shockwave therapy on immune activation and immunosuppressive markers in elderly patients with osteoarthritis: a study protocol for a randomized controlled trial.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2023-12-15 eCollection Date: 2023-01-01

Yilan Sheng, Haiyin Yuan, Lihua Chen, Bo Yu

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Abstract

Objective: This randomized controlled trial aims to compare the effects of high versus low dose extracorporeal shockwave therapy (ESWT) on immune system activation and regulation in elderly patients with osteoarthritis.

Methods: 120 patients aged 65 years and older with knee osteoarthritis will be randomly allocated to receive either high dose (0.25 mJ/mm²) or low dose (0.10 mJ/mm²) ESWT administered weekly for 4 weeks. Serum cytokines, stimulated immune cell subsets, and T regulatory cells will be measured at baseline, 4 weeks after intervention and at 1-month follow-up.

Results: High dose ESWT will increase pro-inflammatory cytokines and decrease immunosuppressive T regulatory cells compared to low dose ESWT in elderly osteoarthritis patients may be the outcome mainly.

Conclusion: This study will provide evidence on ESWT dosing protocols and their differential immunomodulatory effects, which can guide optimal use for musculoskeletal conditions in geriatric populations.

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高剂量和低剂量体外冲击波疗法对老年骨关节炎患者免疫激活和免疫抑制标志物的影响：随机对照试验的研究方案。

目的：本随机对照试验旨在比较高剂量和低剂量体外冲击波疗法（ESWT）对老年骨关节炎患者免疫系统激活和调节的影响：本随机对照试验旨在比较高剂量和低剂量体外冲击波疗法（ESWT）对老年骨关节炎患者免疫系统激活和调节的影响。方法：120 名年龄在 65 岁及以上的膝关节骨关节炎患者将被随机分配接受高剂量（0.25 mJ/mm2）或低剂量（0.10 mJ/mm2）ESWT，每周治疗 4 周。血清细胞因子、受刺激的免疫细胞亚群和T调节细胞将在基线、干预4周后和1个月随访时进行测定：结果：与低剂量 ESWT 相比，高剂量 ESWT 会增加老年骨关节炎患者的促炎细胞因子，减少免疫抑制性 T 调节细胞：本研究将为 ESWT 剂量方案及其不同的免疫调节效果提供证据，从而指导老年肌肉骨骼疾病的最佳治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American journal of clinical and experimental immunology

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