The relationship between caffeine and its metabolites and bone mineral density in postmenopausal women: a cross-sectional analysis from the NHANES database

IF 2.4 Q3 NUTRITION & DIETETICS Journal of Nutritional Science Pub Date : 2024-01-08 DOI:10.1017/jns.2023.98
Sheng Liao, Jianhong Zhou, Hui Chen, Wei Wei, Feng Ye, Yidong Zhang, Zhongrong Zhang
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Abstract

Abstract We aim to explore the association between caffeine and its metabolites and bone mineral density (BMD) in postmenopausal women. Data of 4286 postmenopausal women were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2009–14 in this cross-sectional study. Weighted linear regression and stepwise regression analyses were used to screen the covariates. Weighted univariate and multivariate linear regression analyses were used to explore the associations between caffeine and its metabolites and BMD. The evaluation index was estimated value (β) with 95 % confidence intervals (CIs). We also explored these relationships in age subgroups. The median BMD level among the eligible women was 0⋅7 gm/cm2. After adjusting for covariates including age, body mass index (BMI), fat intake, Calcium (Ca) supplements, diabetes mellitus (DM), angina pectoris, parental history of osteoporosis (OP), anti-osteoporosis therapy, poverty income ratio (PIR), vitamin D (VD) supplements, coronary heart disease (CHD), and previous fracture, we found that caffeine intake was not significantly related to the BMD reduction (β = 0, P = 0⋅135). However, caffeine metabolites, including MethyluricAcid3, MethyluricAcid7, MethyluricAcid37, Methylxanthine3, and Methylxanthine37, were negatively associated with the BMD (all P < 0⋅05). In addition, MethyluricAcid37 and Methylxanthine37 were negatively associated with BMD in females aged <65 years old, while MethyluricAcid3 and Methylxanthine3 were noteworthy in those who aged ≥65 years old. The roles of caffeine and its metabolites in BMD reduction and OP in postmenopausal women needed further exploration.
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绝经后妇女体内咖啡因及其代谢物与骨矿物质密度之间的关系:来自 NHANES 数据库的横断面分析
摘要 我们旨在探讨咖啡因及其代谢物与绝经后妇女骨矿物质密度(BMD)之间的关系。这项横断面研究从 2009-14 年美国国家健康与营养调查(NHANES)数据库中提取了 4286 名绝经后妇女的数据。采用加权线性回归和逐步回归分析筛选协变量。加权单变量和多变量线性回归分析用于探讨咖啡因及其代谢物与 BMD 之间的关系。评价指标为估计值 (β),置信区间为 95%。我们还在年龄分组中探讨了这些关系。符合条件的妇女的 BMD 水平中位数为 0⋅7 gm/cm2。在调整了包括年龄、体重指数 (BMI)、脂肪摄入量、钙 (Ca) 补充剂、糖尿病 (DM)、心绞痛、父母骨质疏松症 (OP)、抗骨质疏松症治疗、贫困收入比 (PIR)、维生素 D (VD) 补充剂、冠心病 (CHD) 和既往骨折在内的协变量后,我们发现咖啡因摄入量与 BMD 下降无显著关系(β = 0,P = 0⋅135)。然而,咖啡因代谢物,包括甲基尿酸3、甲基尿酸7、甲基尿酸37、甲基黄嘌呤3和甲基黄嘌呤37与骨密度呈负相关(所有P < 0⋅05)。此外,MethyluricAcid37 和 Methylxanthine37 与年龄小于 65 岁的女性的 BMD 呈负相关,而 MethyluricAcid3 和 Methylxanthine3 与年龄大于 65 岁的女性的 BMD 呈显著相关。咖啡因及其代谢物在绝经后妇女的 BMD 减少和 OP 中的作用需要进一步探讨。
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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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