Imaging the retinal and choroidal vasculature using Spatio-Temporal Optical Coherence Tomography (STOC-T)

IF 5.3 2区 医学 Q1 ENGINEERING, BIOMEDICAL Biocybernetics and Biomedical Engineering Pub Date : 2024-01-01 DOI:10.1016/j.bbe.2023.12.002
Kamil Liżewski , Slawomir Tomczewski , Dawid Borycki , Piotr Węgrzyn , Maciej Wojtkowski
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Abstract

Spatio-Temporal Optical Coherence Tomography (STOC-T) is a novel imaging technique using light with controlled spatial and temporal coherence. Retinal images obtained using the STOC-T system maintain high resolution in all three dimensions, on a sample of about 700 μm, without the need for mechanical scanning. In the present work, we use known data processing algorithms for optical coherence tomography angiography (OCTA) and modify them to improve the rendering of the vasculature in the human retina at different depths by introducing the angio STOC-T method. The algorithms are primarily sensitive to the strong signal phase variance corresponding to the appearance of a wide Doppler band in STOC-T signals obtained for millisecond exposure times. After using STOC-T angiography, we can render high contrast images of the choroid.

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使用时空光学相干断层扫描 (STOC-T) 对视网膜和脉络膜血管进行成像
时空光学相干断层扫描(STOC-T)是一种新颖的成像技术,使用的光线具有可控的空间和时间相干性。使用 STOC-T 系统获得的视网膜图像在约 700 μm 的样本上都能保持较高的三维分辨率,且无需机械扫描。在本研究中,我们使用了已知的光学相干断层血管成像(OCTA)数据处理算法,并对其进行了修改,通过引入 angio STOC-T 方法,改善了不同深度人体视网膜血管的渲染效果。这些算法主要对在毫秒曝光时间内获得的 STOC-T 信号中出现的宽多普勒频带所对应的强信号相位差非常敏感。使用 STOC-T 血管造影术后,我们可以获得高对比度的脉络膜图像。
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来源期刊
CiteScore
16.50
自引率
6.20%
发文量
77
审稿时长
38 days
期刊介绍: Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.
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