Molecular mechanisms of saliva secretion and hyposecretion

IF 1.8 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE European Journal of Oral Sciences Pub Date : 2024-01-08 DOI:10.1111/eos.12969
Eun-Ah Christine Song, Sul-Hee Chung, Jeong Hee Kim
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Abstract

The exocrine salivary gland secretes saliva, a fundamental body component to maintain oral homeostasis. Saliva is composed of water, ions, and proteins such as amylase, mucins, and immunoglobulins that play essential roles in the digestion of food, lubrication, and prevention of dental caries and periodontitis. An increasing number of people experience saliva hyposecretion due to aging, medications, Sjögren's syndrome, and radiation therapy for head and neck cancer. However, current treatments are mostly limited to temporary symptomatic relief. This review explores the molecular mechanisms underlying saliva secretion and hyposecretion to provide insight into putative therapeutic targets for treatment. Proteins implicated in saliva secretion pathways, including Ca2+-signaling proteins, aquaporins, soluble N-ethylmaleimide-sensitive factor attachment protein receptors, and tight junctions, are aberrantly expressed and localized in patients with saliva hyposecretion, such as Sjögren's syndrome. Analysis of studies on the mechanisms of saliva secretion and hyposecretion suggests that crosstalk between fluid and protein secretory pathways via Ca2+/protein kinase C and cAMP/protein kinase A regulates saliva secretion. Impaired crosstalk between the two secretory pathways may contribute to saliva hyposecretion. Future research into the detailed regulatory mechanisms of saliva secretion and hyposecretion may provide information to define novel targets and generate therapeutic strategies for saliva hyposecretion.

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唾液分泌和分泌不足的分子机制。
唾液腺分泌唾液,是维持口腔平衡的基本人体成分。唾液由水、离子和蛋白质(如淀粉酶、粘蛋白和免疫球蛋白)组成,在消化食物、润滑以及预防龋齿和牙周炎方面发挥着重要作用。越来越多的人由于衰老、药物、斯约格伦综合症以及头颈部癌症的放射治疗而导致唾液分泌不足。然而,目前的治疗方法大多仅限于暂时缓解症状。本综述探讨了唾液分泌和唾液分泌不足的分子机制,以便深入了解可能的治疗靶点。与唾液分泌途径有关的蛋白质,包括 Ca2+ 信号蛋白、水蒸发蛋白、可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体和紧密连接,在唾液分泌过少(如斯约格伦综合征)患者体内异常表达和定位。对唾液分泌和分泌过少机制的研究分析表明,液体和蛋白质分泌途径之间通过 Ca2+ / 蛋白激酶 C 和 cAMP / 蛋白激酶 A 的串联调节唾液分泌。两种分泌途径之间的串扰受损可能会导致唾液分泌过少。未来对唾液分泌和分泌过少的详细调控机制的研究可能会为确定唾液分泌过少的新靶点和制定治疗策略提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Journal of Oral Sciences
European Journal of Oral Sciences 医学-牙科与口腔外科
CiteScore
3.50
自引率
5.30%
发文量
61
审稿时长
2 months
期刊介绍: The European Journal of Oral Sciences is an international journal which publishes original research papers within clinical dentistry, on all basic science aspects of structure, chemistry, developmental biology, physiology and pathology of relevant tissues, as well as on microbiology, biomaterials and the behavioural sciences as they relate to dentistry. In general, analytical studies are preferred to descriptive ones. Reviews, Short Communications and Letters to the Editor will also be considered for publication. The journal is published bimonthly.
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