Breaking the mold with RNA-a "RNAissance" of life science.

IF 4.7 2区 医学 Q1 GENETICS & HEREDITY NPJ Genomic Medicine Pub Date : 2024-01-09 DOI:10.1038/s41525-023-00387-4
Charles H Jones, John R Androsavich, Nina So, Matthew P Jenkins, Derek MacCormack, Andrew Prigodich, Verna Welch, Jane M True, Mikael Dolsten
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Abstract

In the past decade, RNA therapeutics have gone from being a promising concept to one of the most exciting frontiers in healthcare and pharmaceuticals. The field is now entering what many call a renaissance or "RNAissance" which is being fueled by advances in genetic engineering and delivery systems to take on more ambitious development efforts. However, this renaissance is occurring at an unprecedented pace, which will require a different way of thinking if the field is to live up to its full potential. Recognizing this need, this article will provide a forward-looking perspective on the field of RNA medical products and the potential long-term innovations and policy shifts enabled by this revolutionary and game-changing technological platform.

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用 RNA 打破传统--生命科学的 "RNAissance"。
在过去十年中,RNA 疗法已从一个前景看好的概念发展成为医疗保健和制药领域最令人兴奋的前沿领域之一。基因工程和传输系统的进步推动了这一领域的发展,使其能够进行更雄心勃勃的开发工作,目前这一领域正在进入被许多人称为复兴或 "RNAissance "的阶段。然而,这一复兴正以前所未有的速度进行着,如果要充分发挥这一领域的潜力,就需要一种不同的思维方式。认识到这一需求,本文将以前瞻性的视角探讨 RNA 医疗产品领域,以及这一革命性的、改变游戏规则的技术平台可能带来的长期创新和政策转变。
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来源期刊
NPJ Genomic Medicine
NPJ Genomic Medicine Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
1.90%
发文量
67
审稿时长
17 weeks
期刊介绍: npj Genomic Medicine is an international, peer-reviewed journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. The journal defines genomic medicine as "diagnosis, prognosis, prevention and/or treatment of disease and disorders of the mind and body, using approaches informed or enabled by knowledge of the genome and the molecules it encodes." Relevant and high-impact papers that encompass studies of individuals, families, or populations are considered for publication. An emphasis will include coupling detailed phenotype and genome sequencing information, both enabled by new technologies and informatics, to delineate the underlying aetiology of disease. Clinical recommendations and/or guidelines of how that data should be used in the clinical management of those patients in the study, and others, are also encouraged.
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