Membrane Dynamics and Cation Handling in Ferroptosis.

IF 5.3 2区医学 Q1 PHYSIOLOGY Physiology Pub Date : 2024-03-01 Epub Date: 2024-01-09 DOI:10.1152/physiol.00029.2023

Yusuke Hirata, Eikan Mishima

引用次数: 0

Abstract

Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the dysregulation of ion homeostasis via the cation channels, ultimately resulting in plasma membrane rupture. This review illuminates cellular membrane dynamics and cation handling in ferroptosis regulation.

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铁突变过程中的膜动力学和阳离子处理

铁中毒是一种以过度脂质过氧化为特征的调节性细胞死亡，与各种（病理）生理环境有关。在铁中毒过程中，脂质过氧化导致膜特性发生多种变化，并通过阳离子通道导致离子平衡失调，最终导致质膜破裂。这篇综述阐明了铁变态反应调节过程中的细胞膜动力学和阳离子处理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology 医学-生理学

CiteScore

14.50

自引率

0.00%

发文量

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