Comparable Efficacy of Repeated Transcranial Direct Current Stimulation, Cognitive Behavioral Therapy, and Their Combination in Improvement of Cold and Hot Cognitive Functions and Amelioration of Depressive Symptoms.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Journal of Nervous and Mental Disease Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI:10.1097/NMD.0000000000001745
Vahid Nejati, Masoumeh Nozari, Bahram Mirzaian, Hosein Pourshahriar, Mohammad Ali Salehinejad
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Abstract

Abstract: This study aimed to evaluate the effectiveness of repeated transcranial direct current stimulation (rtDCS), cognitive behavioral therapy (CBT), and their combination (rtDCS-CBT) in the treatment of cognitive dysfunction, social cognition, and depressive symptoms in women diagnosed with major depressive disorder (MDD). A total of 40 female participants with MDD were randomly assigned to one of four groups: rtDCS, CBT, rtDCS-CBT, and a control group. The participants' depressive symptoms, executive functions, and social cognition were assessed at baseline, preintervention, postintervention, and during a 1-month follow-up. The rtDCS group received 10 sessions of anodal dorsolateral and cathodal ventromedial prefrontal cortex (2 mA for 20 minutes). The CBT group received 10 sessions of traditional CBT, whereas the combined group received CBT after the tDCS sessions. The results of the analysis of variance indicated that all intervention groups demonstrated significant improvements in depressive symptoms, cognitive dysfunction, and social cognition compared with the control group (all p < 0.001). Furthermore, the rtDCS-CBT group exhibited significantly greater reductions in depressive symptoms when compared with each intervention alone (all p < 0.001). Notably, working memory improvements were observed only in the rtDCS group ( p < 0.001). In conclusion, this study suggests that both CBT and tDCS, either individually or in combination, have a positive therapeutic impact on enhancing executive functions, theory of mind, and depressive symptoms in women with MDD.

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重复经颅直流电刺激疗法、认知行为疗法及其组合疗法在改善冷热认知功能和抑郁症状方面的疗效相当。
摘要:本研究旨在评估重复经颅直流电刺激(rtDCS)、认知行为疗法(CBT)及其组合(rtDCS-CBT)在治疗重度抑郁障碍(MDD)女性患者的认知功能障碍、社会认知和抑郁症状方面的有效性。共有 40 名患有重度抑郁症的女性参与者被随机分配到四组中的一组:rtDCS 组、CBT 组、rtDCS-CBT 组和对照组。分别在基线、干预前、干预后和为期 1 个月的随访期间对参与者的抑郁症状、执行功能和社会认知能力进行评估。rtDCS 组接受了 10 次阳极背外侧和阴极腹侧前额叶皮层治疗(2 毫安,20 分钟)。CBT 组接受了 10 次传统的 CBT 治疗,而联合组则在 tDCS 治疗后接受了 CBT 治疗。方差分析结果表明,与对照组相比,所有干预组在抑郁症状、认知功能障碍和社会认知方面都有显著改善(P 均小于 0.001)。此外,与单独干预相比,rtDCS-CBT 组的抑郁症状明显减轻(所有 p 均小于 0.001)。值得注意的是,只有 rtDCS 组的工作记忆有所改善(p < 0.001)。总之,本研究表明,CBT 和 tDCS 无论是单独使用还是联合使用,都能对增强 MDD 女性患者的执行功能、思维理论和抑郁症状产生积极的治疗效果。
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来源期刊
CiteScore
2.90
自引率
5.30%
发文量
233
审稿时长
3-8 weeks
期刊介绍: The Journal of Nervous and Mental Disease publishes peer-reviewed articles containing new data or ways of reorganizing established knowledge relevant to understanding and modifying human behavior, especially that defined as impaired or diseased, and the context, applications and effects of that knowledge. Our policy is summarized by the slogan, "Behavioral science for clinical practice." We consider articles that include at least one behavioral variable, clear definition of study populations, and replicable research designs. Authors should use the active voice and first person whenever possible.
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