Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of Clinical Practice Pub Date : 2024-01-11 DOI:10.1155/2024/1016247

Abdolkhalegh Keshavarzi, Rahimeh Akrami, Mohammad M. Zarshenas, Saeid Zareie, Tayyeb Ghadimi, Ali Najafi, Mahsa Rostami Chijan, Azizallah Dehghan, Elham Zarenezhad

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Abstract

Burn injuries are considered an important public health problem in the world. Burns are considered the fourth most common kind of trauma in the world, after traffic accidents, falls, and interpersonal violence. Various biochemical agents are involved in the burn healing process such as cytokines (such as IL-6 and TNF-α), antioxidants, and liver and kidney damage biomarkers. Cichorium intybus L. and milk thistle extracts showed a wide range of pharmacological activities such as significant antimicrobial effect and antioxidant activity, as well as anti-inflammatory, antidiabetic, antiproliferative, antiprotozoal, and hepatoprotective effect. Also, these two herbs possess blood-cleansing, detoxifying, laxative, and invigorating activities. Some research confirmed that the preparations of the extract are very suitable for the treatment of nonalcoholic fatty liver disease. This is a double-blind randomized controlled clinical trial. Patients with 2nd and 3rd degree burns have been selected to participate in the study according to the inclusion criteria. A total of 60 patients were selected and divided into intervention and control groups (30 patients in each group). Patients in the intervention group received chicory seed syrup 10 cc three times a day and 1 placebo capsule, and those in the control group received placebo syrup (10 cc three times a day) and one Livergol (140 mg of silymarin in each capsule) capsule. Lab data such as liver function tests, albumin, creatinine, BUN, and hemoglobin were checked every 3 days and 1 week after discharge. The treatment lasted for 4 weeks. According to the results of the study, although the average of liver enzymes at the end of the study does not show a significant difference between the two groups, the level of liver enzymes in each group decreased on the 15th day of the study compared to the first day. This trial is registered with IRCT20180609040016N1.

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评估 Cichorium intybus L. 对烧伤患者肝酶的影响：随机双盲临床试验

烧伤被认为是世界上一个重要的公共卫生问题。烧伤被认为是继交通事故、坠落和人际暴力之后世界上第四大常见创伤。烧伤愈合过程涉及多种生化物质，如细胞因子（如 IL-6 和 TNF-α）、抗氧化剂以及肝脏和肾脏损伤生物标志物。刺五加和奶蓟草提取物显示出广泛的药理活性，如显著的抗菌作用和抗氧化活性，以及抗炎、抗糖尿病、抗增殖、抗原虫和保肝作用。此外，这两种草药还具有清血、解毒、通便和提神的作用。一些研究证实，提取物制剂非常适合治疗非酒精性脂肪肝。这是一项双盲随机对照临床试验。根据纳入标准，2 度和 3 度烧伤患者被选中参与研究。共有 60 名患者被选中，分为干预组和对照组（每组 30 人）。干预组患者服用菊苣籽糖浆，每次 10 毫升，每天三次，并服用 1 粒安慰剂胶囊；对照组患者服用安慰剂糖浆（每次 10 毫升，每天三次）和 1 粒肝宝胶囊（每粒含 140 毫克水飞蓟素）。出院后每 3 天和 1 周检查一次实验室数据，如肝功能检测、白蛋白、肌酐、尿素氮和血红蛋白。治疗持续了 4 周。研究结果显示，虽然研究结束时两组患者的肝酶平均值没有显著差异，但研究第 15 天时，各组患者的肝酶水平均比第一天有所下降。该试验的注册号为 IRCT20180609040016N1。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.