Opioid analgesics prescribing trends 2010–2019 in Slovenia: National database study

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY Human Psychopharmacology: Clinical and Experimental Pub Date : 2024-01-12 DOI:10.1002/hup.2891

Nanca Cebron Lipovec

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Abstract

Objective

Significant increases in global opioid use have been reported in recent decades. This study analyzed opioid utilization in outpatient care in Slovenia between 2010 and 2019.

Methods

This retrospective cross-sectional study performed a nationwide database analysis of all outpatient opioid analgesic prescriptions based on Slovenian health insurance claims data. Prevalence was defined as the number of recipients prescribed at least one opioid per 1000 inhabitants. Opioid consumption was presented as the total number of dispensed prescriptions per 1000 inhabitants and dispensed defined daily doses (DDD) per 1000 inhabitants for each year analyzed.

Results

The age-standardized prevalence of opioid recipients decreased by 21.5% during the study period. Total opioid consumption decreased both in the number of prescriptions (−9.2%) and DDD (−5.4%). Tramadol consumption decreased in terms of the number of prescriptions (−12.2%) and DDD (−2.7%), whereas prescriptions for strong opioids increased (10.2%) and DDDs decreased (−16.2%). The results suggest less intensive prescribing of strong opioids and more intensive prescribing for tramadol. The most frequently used strong opioids were fentanyl and oxycodone/naloxone.

Conclusions

The prevalence of opioid recipients and opioid consumption is decreasing in Slovenia. Further research is needed to understand whether this finding reflects safe use or underuse of these important analgesics.

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斯洛文尼亚 2010-2019 年阿片类镇痛药处方趋势：国家数据库研究。

目的：据报道，近几十年来，全球阿片类药物使用量显著增加。本研究分析了 2010 年至 2019 年期间斯洛文尼亚门诊治疗中阿片类药物的使用情况：这项回顾性横断面研究基于斯洛文尼亚医疗保险报销数据，对所有门诊阿片类镇痛药处方进行了全国性数据库分析。患病率的定义是每 1000 名居民中至少开出一种阿片类药物处方的人数。阿片类药物的消耗量以每 1000 名居民的配药处方总数和每 1000 名居民的配药日剂量（DDD）来表示：结果：在研究期间，阿片类药物接受者的年龄标准化流行率下降了 21.5%。阿片类药物的总消费量在处方数量（-9.2%）和DDD（-5.4%）方面均有所下降。曲马多的处方数量（-12.2%）和处方剂量（-2.7%）均有所减少，而强阿片类药物的处方数量（10.2%）有所增加，处方剂量（-16.2%）有所减少。结果表明，强阿片类药物的处方量减少，而曲马多的处方量增加。最常用的强阿片类药物是芬太尼和羟考酮/纳洛酮：结论：在斯洛文尼亚，阿片类药物接受者和阿片类药物消费的流行率正在下降。需要开展进一步研究，以了解这一发现是否反映了这些重要镇痛药的安全使用或使用不足。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Psychopharmacology: Clinical and Experimental 医学-精神病学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design