Lipid-based mesoporous silica nanoparticles: a paradigm shift in management of pancreatic cancer.

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2023-11-01 Epub Date: 2024-01-12 DOI:10.4155/ppa-2023-0024
Kiran Kumar Bellapu, Ramesh Joga, Bharthi R Kannan, Sravani Yerram, Priya Varpe, Tejaswini Mergu, Pavan Y Vasu, Saurabh Srivastava, Sandeep Kumar
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Abstract

Pancreatic adenocarcinoma, a devastating disease, has the worst cancer prognosis in humans. It often develops resistance to common chemotherapy medications, such as gemcitabine, taxol and 5-fluorouracil. The dense stroma limits therapeutic efficacy in treating this disease. Low or limited drug loading capacity is another problem with current chemotherapeutic agents. There is a need to develop novel approaches to overcome these issues. Hence, an innovative approach has been proposed to co-deliver both hydrophilic (Gemcitabine) and hydrophobic (Paclitaxel) drugs in a single carrier using lipid bilayer-mesoporous silica nanoparticles (LB-MSNP). MSNPs offer effective drug delivery due to their superior bioavailability and physicochemical properties. Further, in order to achieve clinical translation and regulatory approval, toxicity and biodegradability of MSNPs must be resolved.

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基于脂质的介孔二氧化硅纳米粒子:胰腺癌治疗模式的转变。
胰腺腺癌是一种毁灭性疾病,是人类预后最差的癌症。它常常对吉西他滨、紫杉醇和 5-氟尿嘧啶等常见化疗药物产生抗药性。致密的基质限制了治疗这种疾病的疗效。药物负荷能力低或有限是目前化疗药物的另一个问题。需要开发新的方法来克服这些问题。因此,有人提出了一种创新方法,利用脂质双分子层-介孔二氧化硅纳米颗粒(LB-MSNP)在单一载体中同时递送亲水性药物(吉西他滨)和疏水性药物(紫杉醇)。MSNP 具有优异的生物利用度和理化特性,可提供有效的药物输送。此外,为了实现临床转化和监管审批,必须解决 MSNP 的毒性和生物降解性问题。
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Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
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0.00%
发文量
22
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