Andrew D Smith, Matthew T Westwood, Kevin Kasten, Lotte Stockhammer, R. D. Río-Rodríguez, Jose A. Fernández‐Salas, Andreas Eitzinger, Alexandra M. Z. Slawin, Mario Waser, José Alemán, Armin Ofial
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引用次数: 0
Abstract
The incorporation of the CF 2 motif within organic structures is known to affect the susceptibility of functional groups to oxidation, as well as altering conformation and reactivity. In this manuscript, the incorporation of the CF 2 functional group within an isothiourea catalyst skeleton to give C(3)-F 2 -HBTM is reported. Effective gram-scale routes to both racemic and enantiopure heterocyclic Lewis bases are developed, with preliminary catalytic and kinetic activity evaluated
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