IMPROVED SOLUBILITY OF CHOLECALCIFEROL AS BOVINE SERUM ALBUMIN (BSA) NANOPARTICLES

Q2 Pharmacology, Toxicology and Pharmaceutics International Journal of Applied Pharmaceutics Pub Date : 2024-01-07 DOI:10.22159/ijap.2024v16i1.49422

Yenni Puspita Tanjung, M. Barliana, I. Joni, A. Chaerunisaa

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Abstract

Objective: This study aims to report the optimum formula for BSA nanoparticles cholecalciferol (BSA-NP cholecalciferol), which can increase the solubility of cholecalciferol.Methods: BSA cholecalciferol nanoparticles was prepared by desolvation method with variations in solvent/non-solvent ratio, BSA concentration, pH of BSA solution, and cholecalciferol concentration. For this purpose, particle size, polydispersity index, and zeta potential were measured. Furthermore, the solubility test of the best BSA-NPs cholecalciferol formula was carried out.Results: The most optimal BSA nanoparticle cholecalciferol characterization results have a particle size of 166.6±50.3 nm, a zeta potential of-32.1 mV, and a percentage encapsulation efficiency (%EE) for cholecalciferol of 82.9±0.72%. The solubility of BSA-NP cholecalciferol is four times higher than that of pure cholecalciferol.Conclusion: The optimum formula for BSA-NP cholecalciferol with a solvent/non-solvent ratio of 1/2, a concentration of BSA of 2.5%, a BSA solution pH 6, and a cholecalciferol concentration of 0.1% will increase the solubility of cholecalciferol by four times compared to pure cholecalciferol.

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提高牛血清白蛋白（bsa）纳米颗粒中胆钙化醇的溶解度

研究目的本研究旨在报告能提高胆钙化醇溶解度的 BSA 纳米颗粒胆钙化醇（BSA-NP 胆钙化醇）的最佳配方：方法：采用脱溶法制备 BSA 胆钙化醇纳米粒子，并改变溶剂/非溶剂比例、BSA 浓度、BSA 溶液 pH 值和胆钙化醇浓度。为此，对粒度、多分散指数和 zeta 电位进行了测量。此外，还对最佳 BSA-NPs 胆钙化醇配方进行了溶解度测试：结果：最佳 BSA 纳米粒子胆钙化醇表征结果的粒径为 166.6±50.3 nm，zeta 电位为-32.1 mV，胆钙化醇的封装效率（%EE）为 82.9±0.72%。BSA-NP胆钙化醇的溶解度是纯胆钙化醇的四倍：结论：BSA-NP 胆钙化醇的最佳配方为溶剂/非溶剂比为 1/2、BSA 浓度为 2.5%、BSA 溶液 pH 值为 6、胆钙化醇浓度为 0.1%，与纯胆钙化醇相比，BSA-NP 胆钙化醇的溶解度提高了四倍。

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来源期刊

International Journal of Applied Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

219

期刊介绍： International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.