Evaluation of Adsorption Therapy as an Extracorporeal Blood Purification Technique in Critically Ill Covid-19 Patients

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Romanian Journal of Military Medicine Pub Date : 2024-01-01 DOI:10.55453/rjmm.2024.127.1.7
Mehmet E. Yuksel, Nazan H. Selmi, Ç. M. Ayaz, Seval Izdes
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Abstract

"We aimed to evaluate the efficacy of adsorption therapy as an extracorporeal blood purification technique in critically ill patients with Coronavirus disease 2019 (COVID-19). A retrospective analysis was performed on 17 adult patients with severe COVID-19, who underwent adsorption therapy using an HA330 cartridge, at Ankara City Hospital. Each adsorption therapy was administered for three consecutive days, and each therapy session lasted three hours. Several parameters, including cytokine levels, blood count, biochemistry panel, clinical status, and mortality rate were assessed before and after each therapy session. The results obtained from this study revealed that adsorption therapy reduced IL-6 levels and improved oxygenation in the short term. However, heart rate, mean arterial pressure and SOFA score did not demonstrate significant changes. Notably, the dose of norepinephrine increased after the third session. Regrettably, only 4 out of 17 patients (23.5%) survived. Consequently, adsorption therapy appears to be effective in reducing IL-6 levels in severe COVID-19 patients. Nonetheless, further investigation is warranted to evaluate its impact on clinical outcomes."
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将吸附疗法作为体外血液净化技术用于重症 Covid-19 患者的评估
"我们的目的是评估吸附疗法作为体外血液净化技术对 2019 年冠状病毒病(COVID-19)重症患者的疗效。安卡拉市医院对 17 名重症 COVID-19 成人患者进行了回顾性分析,这些患者使用 HA330 血盒接受了吸附疗法。每次吸附治疗连续进行三天,每次治疗持续三小时。每次治疗前后都会对细胞因子水平、血细胞计数、生化检查、临床状态和死亡率等参数进行评估。研究结果表明,吸附疗法在短期内降低了 IL-6 水平,改善了氧合。然而,心率、平均动脉压和 SOFA 评分并未出现显著变化。值得注意的是,去甲肾上腺素的剂量在第三个疗程后有所增加。遗憾的是,17 名患者中只有 4 人(23.5%)存活。因此,吸附疗法似乎能有效降低重症 COVID-19 患者的 IL-6 水平。尽管如此,仍有必要进行进一步研究,以评估其对临床结果的影响"。
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来源期刊
Romanian Journal of Military Medicine
Romanian Journal of Military Medicine MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
2
审稿时长
12 weeks
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