Use of the dustiness index in combination with the handling energy factor for exposure modelling of nanomaterials

IF 4.7 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES NanoImpact Pub Date : 2024-01-01 DOI:10.1016/j.impact.2024.100493
Carla Ribalta , Alexander C.Ø. Jensen , Neeraj Shandilya , Camilla Delpivo , Keld A. Jensen , Ana Sofia Fonseca
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Abstract

The use of modelling tools in the occupational hygiene community has increased in the last years to comply with the different existing regulations. However, limitations still exist mainly due to the difficulty to obtain certain key parameters such as the emission rate, which in the case of powder handling can be estimated using the dustiness index (DI). The goal of this work is to explore the applicability and usability of the DI for emission source characterization and occupational exposure prediction to particles during nanomaterial powder handling. Modelling of occupational exposure concentrations of 13 case scenarios was performed using a two-box model as well as three nano-specific tools (Stoffenmanager nano, NanoSafer and GUIDEnano). The improvement of modelling performance by using a derived handling energy factor (H) was explored. Results show the usability of the DI for emission source characterization and respirable mass exposure modelling of powder handling scenarios of nanomaterials. A clear improvement in modelling outcome was obtained when using derived quartile-3 H factors with, 1) Pearson correlations of 0.88 vs. 0.52 (not using H), and 2) ratio of modelled/measured concentrations ranging from 0.9 to 10 in 75% cases vs. 16.7% of the cases when not using H. Particle number concentrations were generally underpredicted. Using the most conservative H values, predictions with ratios modelled/measured concentrations of 0.4–3.6 were obtained.

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将尘埃度指数与处理能量系数相结合,用于纳米材料的暴露建模。
近年来,职业卫生领域越来越多地使用建模工具,以符合各种现行法规。然而,主要由于难以获得某些关键参数(如排放率),因此仍然存在局限性,在粉末处理情况下,可以使用粉尘指数(DI)来估算排放率。这项工作的目标是探索 DI 在纳米材料粉末处理过程中用于排放源特征描述和颗粒物职业暴露预测的适用性和可用性。使用双箱模型以及三种纳米专用工具(Stoffenmanager nano、NanoSafer 和 GUIDEnano)对 13 种情况下的职业接触浓度进行了建模。研究还探讨了通过使用衍生的处理能量系数(H)来提高建模性能的问题。结果表明,DI 适用于纳米材料粉末处理方案的排放源特征描述和可吸入质量暴露建模。使用衍生的四分位数-3H 因子时,建模结果有明显改善:1)皮尔逊相关性为 0.88,而不使用 H 时为 0.52;2)75% 的建模/测量浓度比为 0.9 至 10,而不使用 H 时为 16.7%。使用最保守的 H 值时,预测的模拟/测量浓度比为 0.4-3.6。
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来源期刊
NanoImpact
NanoImpact Social Sciences-Safety Research
CiteScore
11.00
自引率
6.10%
发文量
69
审稿时长
23 days
期刊介绍: NanoImpact is a multidisciplinary journal that focuses on nanosafety research and areas related to the impacts of manufactured nanomaterials on human and environmental systems and the behavior of nanomaterials in these systems.
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