IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2026-02-06 DOI: 10.1016/j.impact.2026.100611

Kirsten Rasmussen, Richard Handy, Ivana Vinković Vrček, Hubert Rauscher, Mar Gonzalez, Tommaso Serchi

The Organisation for Economic Co-operation and Development (OECD) has adapted or newly developed selected OECD test guidelines (TGs) and guidance documents (GDs) to address regulatory testing of nanomaterials. The "Guidance on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials" (GSPD) is a cornerstone document in this context. It presents the general approach to sample preparation, whereas TGs and GDs often include information for the specific test. The GSPD addresses sample preparation of nanomaterials for testing physical and chemical properties, mammalian and environmental toxicity, and environmental fate. The third edition of the GSPD, published in 2025, integrates the substantial progress over the last decade in addressing issues related to sample preparation and dosimetry, i.e. the lessons learnt. The GSPD captures the progress in sample preparation protocols, noting that an overarching protocol is not available, and the deeper understanding of dosimetry and effective dose. Dose estimation is now underpinned by in silico tools. Across testing, medium composition is a key determinant of nanomaterial behaviour and should be systematically addressed. The sample preparation for physical and chemical properties includes one new endpoint, hydrophobicity. The GSPD reflects the growing consensus on the key practical issues for preparing nanomaterial samples in media for environmental studies. The information on sample preparation for in vitro testing is completely new, and the information on mammalian toxicity sample preparation reflects the leap in knowledge. The glossary has been significantly expanded. This paper provides an overview of the new elements in the updated GSPD.

经济合作与发展组织（OECD）已经调整或新开发了经选择的OECD测试指南（TGs）和指导文件（GDs）来解决纳米材料的监管测试问题。“人造纳米材料安全测试的样品制备和剂量学指南”（GSPD）是这方面的基石文件。它介绍了样品制备的一般方法，而tg和GDs通常包括特定测试的信息。GSPD涉及用于测试物理和化学性质、哺乳动物和环境毒性以及环境命运的纳米材料的样品制备。2025年出版的GSPD第三版整合了过去十年在解决样品制备和剂量学相关问题方面取得的实质性进展，即吸取的经验教训。GSPD概述了样品制备方案的进展，指出目前还没有一个总体方案，以及对剂量学和有效剂量的更深入了解。剂量估计现在以计算机工具为基础。在整个测试中，介质成分是纳米材料行为的关键决定因素，应该系统地加以解决。样品的物理和化学性质的制备包括一个新的端点，疏水性。GSPD反映了在环境研究介质中制备纳米材料样品的关键实际问题上日益增长的共识。体外测试样品制备的信息是全新的，哺乳动物毒性样品制备的信息反映了知识的飞跃。词汇表已大大扩充。本文概述了更新后的GSPD中的新元素。

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引用次数: 0

Dustiness and aerosol characteristics of nanocellulose powders: Implications for workplace exposure and safety management 纳米纤维素粉末的粉尘和气溶胶特性：对工作场所暴露和安全管理的影响。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2026-01-01 DOI: 10.1016/j.impact.2025.100610

Isamu Ogura, Mari Kotake

Nanocellulose materials, including cellulose nanofibers and cellulose nanocrystals, are promising renewable materials with diverse industrial applications. However, potential worker exposure during the handling of dry powders remains a concern. In this study, the dustiness and aerosol characteristics of nine nanocellulose powders were evaluated using the small rotating drum method specified in EN 17199. Aerosolized nanocellulose was characterized using real-time instruments, gravimetric analysis, and microscopic observation of filter-collected particles. All samples generated respirable particles, with mass-based dustiness indices ranging from 10 to 300 mg/kg, comparable to those of other nanomaterials. Aerosolized nanocellulose did not appear as isolated fibers but rather as aggregated or agglomerated particles approximately 0.1–10 μm in size. These findings suggest that, under conditions represented by the rotating drum method, aerosolized nanocellulose predominantly appears as particulate matter rather than isolated fibers. Nonetheless, emission and exposure control measures can be necessary when handling dry nanocellulose powders, given the magnitude of their mass-based dustiness indices. The performance and limitations of portable aerosol instruments were also assessed. Optical particle sizer measurements were occasionally influenced by artifacts that may arise from high concentrations of particles larger than the respirable size range, while dust monitors tended to underestimate concentrations for samples containing a large fraction of coarse particles. Despite these limitations, these instruments can provide useful information for workplace safety management when their constraints are taken into account. Overall, this study provides a scientific basis for developing effective exposure assessment and control strategies to support safe handling of nanocellulose powders in occupational environments.

纳米纤维素材料，包括纤维素纳米纤维和纤维素纳米晶体，是一种具有广泛工业应用前景的可再生材料。然而，工人在处理干粉过程中潜在的暴露仍然是一个问题。在这项研究中，使用en17199中规定的小旋转鼓法评估了9种纳米纤维素粉末的粉尘和气溶胶特性。采用实时仪器、重量分析和过滤器收集颗粒的显微观察对雾化纳米纤维素进行了表征。所有样品均产生可吸入颗粒，其质量基粉尘指数在10至300 mg/kg之间，与其他纳米材料相当。雾化后的纳米纤维素不是孤立的纤维，而是聚集或凝聚的颗粒，大小约为0.1-10 μm。这些发现表明，在旋转鼓法所代表的条件下，雾化的纳米纤维素主要表现为颗粒物质，而不是孤立的纤维。尽管如此，在处理干燥纳米纤维素粉末时，考虑到其质量为基础的工业指数的大小，排放和暴露控制措施是必要的。对便携式气溶胶仪器的性能和局限性进行了评估。光学粒度仪的测量有时会受到大于可吸入粒度范围的高浓度颗粒可能产生的伪影的影响，而粉尘监测仪往往会低估含有大量粗颗粒的样品的浓度。尽管存在这些限制，但如果考虑到这些限制，这些工具可以为工作场所安全管理提供有用的信息。总的来说，本研究为制定有效的暴露评估和控制策略提供了科学依据，以支持纳米纤维素粉末在职业环境中的安全处理。

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引用次数: 0

Maize adaptation to low-dose nanoplastic–lead co-contamination: Foliar metabolic reprogramming and phyllospheric microbiome restructuring 玉米对低剂量纳米塑料-铅共污染的适应：叶面代谢重编程和叶根圈微生物组重组

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-12-18 DOI: 10.1016/j.impact.2025.100606

Qian Fu, Jin-sheng Shi, Jin-long Lai, Yu Zhang, Yan Huang, Xue-gang Luo

Nanoplastics (NPs) and lead (Pb), as emerging environmental pollutants, have been rarely studied in terms of their combined effects on crop growth and metabolic processes under low-dose co-exposure conditions. This study simulated rain-mediated co-exposure of maize seedlings to NPs and Pb at environmentally relevant concentrations (400 μg/L) to elucidate the metabolic responses in leaves and the dynamics of phyllosphere microbial communities. Short-term exposure (45 days) to NPs and Pb did not significantly impair maize seedling growth; however, it induced the accumulation of essential macronutrients in leaves. The metabolic adaptation of maize leaves to NPs and Pb exposure was characterized by a reduction in carbon metabolic flux coupled with an enhancement in lipid metabolic flux. Furthermore, plants responded to co-exposure by activating key metabolic pathways such as those involving ABC transporters, nucleotide metabolism, and amino acid metabolism. Concurrently, the phyllosphere microbiome exhibited structural reorganization, with enrichment of stress-tolerant microbial taxa (e.g., Acidobacteria, Chloroflexi), activation of microbial redox systems, and enhanced capacity of the leaf microbiota to adapt to NPs and Pb exposure. The findings offer theoretical insights into assessing agricultural environmental impacts associated with combined exposure to emerging pollutants, phyllosphere microbial ecology, and plant stress resistance.

纳米塑料（NPs）和铅（Pb）作为新兴的环境污染物，在低剂量共暴露条件下对作物生长和代谢过程的综合影响研究很少。本研究模拟了降雨介导的玉米幼苗对环境相关浓度（400 μg/L） NPs和Pb的共同暴露，以阐明叶片代谢响应和层际微生物群落动态。短期（45 d）暴露于NPs和Pb对玉米幼苗生长无显著影响；然而，它诱导了叶片中必需常量营养素的积累。玉米叶片对NPs和Pb的代谢适应表现为碳代谢通量的减少和脂质代谢通量的增加。此外，植物通过激活关键的代谢途径，如涉及ABC转运体、核苷酸代谢和氨基酸代谢的途径，对共暴露做出反应。与此同时，叶根圈微生物群呈现结构重组，耐胁迫微生物类群（如酸杆菌、绿柔菌）丰富，微生物氧化还原系统激活，叶片微生物群适应NPs和Pb暴露的能力增强。这些发现为评估与新出现的污染物、层圈微生物生态和植物抗逆性联合暴露相关的农业环境影响提供了理论见解。

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引用次数: 0

The legacy in nanosafety research and future perspectives. 纳米安全研究的遗产和未来展望。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-12-17 DOI: 10.1016/j.impact.2025.100609

Bernd Nowack, Philip Demokritou

引用次数: 0

Impact of titanium dioxide and cerium dioxide nanoparticle mixtures on the green alga Raphidocelis subcapitata 二氧化钛和二氧化铈纳米颗粒混合物对绿藻类的影响。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-12-16 DOI: 10.1016/j.impact.2025.100608

Mariam Bakir , Isabel Abad-Alvaro , Francisco Laborda , Vera I. Slaveykova

Engineered nanoparticles (NPs) occur as mixtures in the environment, making the study of their combined toxicity more realistic than the assessment of individual NPs. Interactions between NPs can alter toxicity profiles, producing synergistic, antagonistic, or additive effects, yet current environmental assessments often overlook these cocktail effects. This study investigated the effects of titanium dioxide NPs (TiO₂-NPs) and cerium dioxide NPs (CeO₂-NPs) mixtures on the green alga Raphidocelis subcapitata compared individual NP exposures. Four mixtures with varying NP ratios were designed based on the toxicity units (TUs) concept and EC₅₀ growth-inhibition values for TiO₂-NPs of 28.3 ± 1.16 mg L⁻¹, and EC₅₀ for CeO₂-NPs of 13.6 ± 0.57 mg L⁻¹. Growth inhibition, reactive oxygen species (ROS) generation, and membrane damage were assessed using flow cytometry (FCM), while uptake was analyzed by single-cell inductively coupled plasma mass spectrometry (SC-ICP-MS). Single-particle (SP) -ICP-MS distinguished NP size distribution and dissolution in mixtures.

Results revealed antagonistic interactions in mixtures, with growth inhibition lower than expected based on individual treatments. The difference between predicted and measured TUs in the mixture treatments, used as a measure for the extent of antagonistic interaction ranged from 0.66 to 1.76. Cells with elevated ROS generation showed a two- to four-fold reduction in the mixtures versus single NP treatments. SC-ICP-MS indicated reduced bioavailability of NPs in mixtures: intracellular TiO₂-NP content decreased from 15.7 to 24.3 fg cell⁻¹ (single) to 12.9–15.9 fg cell⁻¹ (mixture), and CeO₂-NP content dropped from 3.6 to 8.6 fg cell⁻¹ to 2.7–3.8 fg cell⁻¹. This study demonstrates the importance of assessing NP mixture toxicity using advanced single-event techniques, such as FCM, SP- and SC-ICP-MS, to discriminate the fate and bioavailability of NPs present in mixtures and to better understand their environmental impacts.

工程纳米颗粒（NPs）在环境中以混合物的形式存在，使得它们的联合毒性研究比单一np评估更现实。NPs之间的相互作用可以改变毒性特征，产生协同、拮抗或加性效应，但目前的环境评估往往忽略了这些鸡尾酒效应。本文研究了二氧化钛NPs （TiO2-NPs）和二氧化铈NPs （CeO2-NPs）混合物对绿藻类Raphidocelis subcapitata的影响。根据毒性单位概念（TUs）设计了四种不同NP比的混合物，EC₅0对TiO2-NPs的生长抑制值为28.3 ± 1.16 mg L-1，对CeO2-NPs的EC50为13.6 ± 0.57 mg L-1。使用流式细胞术（FCM）评估生长抑制，活性氧（ROS）生成和膜损伤，同时使用单细胞诱导耦合等离子体质谱（SC-ICP-MS）分析摄取。单颗粒SP-ICP-MS检测了NP在混合物中的粒径分布和溶出度。结果显示，在混合物中拮抗相互作用，生长抑制低于基于单独处理的预期。在混合处理中，预测和测量的TUs之间的差异，用作拮抗相互作用程度的测量，范围为0.66至1.76。与单一NP处理相比，ROS生成升高的细胞在混合物中减少了两到四倍。SC-ICP-MS显示混合物中NPs的生物利用度降低：细胞内TiO 2 -NP含量从15.7 ~ 24.3 fg cell-1（单个）降至12.9 ~ 15.9 fg cell-1（混合物），CeO 2 -NP含量从3.6 ~ 8.6 fg cell-1降至2.7 ~ 3.8 fg cell-1。这项研究证明了使用先进的单事件技术评估NP混合物毒性的重要性，例如FCM， SP-和SC-ICP-MS，以区分混合物中存在的NP的命运和生物利用度，并更好地了解它们对环境的影响。

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引用次数: 0

Microplastic pollution in rivers and lakes of India: Sources, ecotoxicological impacts, and removal strategies 印度河流和湖泊中的微塑料污染：来源、生态毒理学影响和去除策略。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-12-07 DOI: 10.1016/j.impact.2025.100604

Avinash Kumar , Vineet Kumar Poddar , Sourav Sardar , Arup Mistri , Ayan Srivastava

Microplastic pollution in freshwater ecosystems, particularly the rivers and lakes of India, has emerged as a significant environmental concern. This review synthesises the current understanding of microplastic pollution in these vital water bodies, encompassing their diverse sources, the ecotoxicological impacts on aquatic biota with a specific focus on Indian species, and the array of removal strategies being explored. The escalating production and consumption of plastics globally have led to the widespread presence of microplastics in various environmental compartments, posing threats to ecological integrity and potentially human health. Indian rivers and lakes, crucial for water supply, agriculture, and biodiversity, are increasingly affected by microplastic contamination from anthropogenic activities, including industrial discharge, domestic waste, agricultural runoff, and tourism. Studies on the eco-toxicology show negative impacts on aquatic organisms, such as bioaccumulation, oxidative stress, histopathological alterations, decreased growth rates, and changed behaviour in fish and other aquatic invertebrates. Additionally, this review critically examines the current literature, highlighting the abundance, distribution, and characteristics of microplastics in Indian freshwater systems, their adverse effects on aquatic organisms, and the efficacy and sustainability of existing and emerging remediation techniques. This thorough investigation further emphasizes the importance of tackling microplastic pollution in India's freshwater systems and points out the necessity of integrated management strategies that incorporate better waste management, and advanced treatment technologies. It also identifying critical knowledge gaps and proposing directions for future research to address this complex and growing environmental challenge.

淡水生态系统中的微塑料污染，特别是印度的河流和湖泊，已经成为一个重大的环境问题。这篇综述综合了目前对这些重要水体中微塑料污染的了解，包括它们的不同来源，对水生生物群的生态毒理学影响，特别是对印度物种的影响，以及正在探索的一系列去除策略。全球塑料生产和消费不断增加，导致微塑料广泛存在于各种环境隔间中，对生态完整性和潜在的人类健康构成威胁。印度的河流和湖泊对供水、农业和生物多样性至关重要，但它们越来越多地受到工业排放、生活垃圾、农业径流和旅游业等人为活动造成的微塑料污染的影响。生态毒理学研究显示了对水生生物的负面影响，如生物积累、氧化应激、组织病理学改变、生长速度下降以及鱼类和其他水生无脊椎动物的行为改变。此外，本文对现有文献进行了批判性的研究，强调了印度淡水系统中微塑料的丰度、分布和特征，它们对水生生物的不利影响，以及现有和新兴修复技术的有效性和可持续性。这项彻底的调查进一步强调了解决印度淡水系统中微塑料污染的重要性，并指出了综合管理战略的必要性，该战略将更好的废物管理和先进的处理技术结合起来。它还确定了关键的知识差距，并为未来的研究提出了方向，以解决这一复杂和日益增长的环境挑战。

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引用次数: 0

Polystyrene nanoplastics induce ovarian granulosa cell senescence via autophagy suppression 聚苯乙烯纳米塑料通过抑制细胞自噬诱导卵巢颗粒细胞衰老。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-12-06 DOI: 10.1016/j.impact.2025.100607

Haoyue Hu , Haotong Ouyang , Lien Ma , Qianhan Xu , You Peng , Meng Meng , Tao Zhang

Polystyrene nanoplastics (PS-NPs) pose escalating threats to female reproductive health, yet their impact on ovarian granulosa cell senescence remains poorly understood. This study investigates the mechanisms by which 50 nm PS-NPs induce senescence in human ovarian granulosa KGN cells. Exposure to PS-NPs (50–250 μg/mL) triggered concentration-dependent cellular senescence in KGN cells, as evidenced by increased senescence-associated β-galactosidase (SA-β-gal) activity, suppressed Lamin B1 expression, and enhanced activation of the P53/P16 signaling axis. PS-NPs also triggered both a senescence-associated secretory phenotype (SASP) and senescence-associated mitochondrial dysfunction (SAMD), marked by upregulated pro-inflammatory cytokines (IL-6, IL-8, IL-1β) and increased reactive oxygen species (ROS) levels coupled with mitochondrial membrane potential (ΔΨm) disruption. Mechanistically, we demonstrated that PS-NP-induced senescence in KGN cells is mediated by autophagy suppression. Autophagy modulation experiments revealed that rapamycin (an autophagy activator) reversed PS-NP-triggered senescence, SASP and SAMD, whereas 3-methyladenine (3-MA, an autophagy inhibitor) exacerbated these effects. These results establish autophagy suppression as a critical mediator of PS-NP-induced granulosa cell senescence and highlight the therapeutic potential of autophagy enhancement to mitigate PS-NPs-associated reproductive toxicity. Our study provides novel insights into the molecular pathways linking environmental nanoplastics to premature ovarian aging, underscoring the urgent need for strategies to address nanoplastics exposure in reproductive health.

聚苯乙烯纳米塑料（PS-NPs）对女性生殖健康的威胁日益加剧，但其对卵巢颗粒细胞衰老的影响尚不清楚。本研究探讨了50 nm PS-NPs诱导人卵巢颗粒KGN细胞衰老的机制。暴露于PS-NPs（50-250 μg/mL）可引发KGN细胞的浓度依赖性细胞衰老，衰老相关的β-半乳糖苷酶（SA-β-gal）活性增加，Lamin B1表达抑制，P53/P16信号轴活化增强。PS-NPs还引发衰老相关分泌表型（SASP）和衰老相关线粒体功能障碍（SAMD），其特征是促炎细胞因子（IL-6、IL-8、IL-1β）上调，活性氧（ROS）水平升高，以及线粒体膜电位（ΔΨm）破坏。在机制上，我们证明了ps - np诱导的KGN细胞衰老是由自噬抑制介导的。自噬调节实验显示，雷帕霉素（一种自噬激活剂）逆转ps - np引发的衰老、SASP和SAMD，而3-甲基腺嘌呤（3-MA，一种自噬抑制剂）加剧了这些作用。这些结果证实了自噬抑制是ps - nps诱导的颗粒细胞衰老的关键介质，并强调了自噬增强在减轻ps - nps相关生殖毒性方面的治疗潜力。我们的研究为将环境纳米塑料与卵巢早衰联系起来的分子途径提供了新的见解，强调了迫切需要解决纳米塑料暴露在生殖健康中的策略。

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引用次数: 0

Corrigendum to 'Multi-technique approach for the characterization of titanium dioxide color additive' [NanoImpact Volume 40 October 2025 100599]. “表征二氧化钛颜色添加剂的多技术方法”的勘误表[NanoImpact Volume 40 October 2025 100599]。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-12-02 DOI: 10.1016/j.impact.2025.100603

Sadia Afrin Khan, Sheng Dong, Martine Ferguson, Betsy Jean Yakes, Raymond P Briñas

引用次数: 0

Impact of tire particles and tire leachate contaminants on plant physiology and soil health: Case study in mung bean and tomato 轮胎颗粒和轮胎渗滤液污染物对植物生理和土壤健康的影响：以绿豆和番茄为例。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-11-30 DOI: 10.1016/j.impact.2025.100601

Snehal Wasnik, Shuo Cheng, Kimleng Keang, Haoge Zhang, Jeffrey S. Cross

Tire particles and their associated leachates represent emerging microplastic pollution of growing concern. The accumulation of tire-derived pollutants beside road agricultural systems remains poorly characterized, yet species-specific responses to these pollutants also remain poorly understood. This study investigated the differential impacts of tire particles and tire leachate on germination, plant growth, photosynthetic function, and oxidative stress response in two ecologically important crops. Mung bean (Vigna radiata) and tomato (Solanum lycopersicum) were exposed to tire particles (0.1, 1, and 10 g/kg) and tire leachate (10 %, 20 % and 30 %) in soil medium under controlled greenhouse conditions. The tomato plant exhibited superior resistance, mounting a robust, induced superoxide dismutase (SOD) response that successfully mitigated systemic stress and maintained growth. Tire leachate exposure in mung beans causes high Molondialdegyde (MDA) accumulation and significant chlorophyll degradation. This damage coincided with the signifying failure of the antioxidant defense system. Tire-leachate significantly alters soil dynamics, increasing available nitrogen in mung bean soil while causing phosphorus immobilization in tomato soil, demonstrating complex tire-derived contaminant soil-plant interactions. Principal components analysis (PCA) shows a distinct metabolic fingerprint for each treatment, inducing fundamental biochemical reorganization in both species. This study demonstrates that tire contamination effects are highly species-dependent, with mung bean roots being sensitive and inhibition, while tomato growth remained stable, despite clear internal stress. The findings highlight that the highly bioavailable leachate fraction poses the most acute threat to plant health and underscore the critical need for species-specific risk assessment for tire-derived contamination.

轮胎颗粒及其相关渗滤液代表了日益受到关注的新兴微塑料污染。公路农业系统旁轮胎衍生污染物的积累特征仍然很差，但对这些污染物的物种特异性反应也知之甚少。本文研究了轮胎颗粒和轮胎渗滤液对两种重要生态作物萌发、植物生长、光合功能和氧化胁迫响应的差异影响。在可控温室条件下，将绿豆（Vigna radiata）和番茄（Solanum lycopersicum）分别暴露于轮胎颗粒（0.1、1和10 g/kg）和轮胎渗滤液（10 %、20 %和30 %）的土壤培养基中。番茄植株表现出优异的抗性，建立了强大的诱导超氧化物歧化酶（SOD）反应，成功地减轻了系统胁迫并保持了生长。轮胎渗滤液暴露在绿豆中导致高的丙二醛（MDA）积累和显著的叶绿素降解。这种损害与抗氧化防御系统的显著失败相吻合。轮胎渗滤液显著改变了土壤动力学，增加了绿豆土壤的速效氮，同时导致番茄土壤的磷固定，表明轮胎衍生的污染物土壤-植物之间存在复杂的相互作用。主成分分析（PCA）显示，每种处理都有不同的代谢指纹，诱导了两种物种的基本生化重组。该研究表明，轮胎污染的影响是高度依赖物种的，绿豆根是敏感和抑制的，而番茄生长保持稳定，尽管有明显的内应力。研究结果强调了高度生物利用的渗滤液部分对植物健康构成最严重的威胁，并强调了对轮胎源污染进行特定物种风险评估的迫切需要。

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引用次数: 0

nanoPharos: A case study on FAIR (Nano)material (Meta)data management 纳米haros: FAIR（纳米）材料（元）数据管理的案例研究。

IF 5.5 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

NanoImpact

Pub Date : 2025-11-29 DOI: 10.1016/j.impact.2025.100602

Anastasios G. Papadiamantis , Andreas Tsoumanis , Georgia Melagraki , Iseult Lynch , Antreas Afantitis

Novel and advanced materials, including nanomaterials (NMs), are vital for diverse industrial and societal applications, yet conventional Research and Innovation (R&I) and Research and Development (R&D) can take decades to reach market deployment. Digitising these processes to support safe and sustainable material development, and reduce reliance on animal testing, requires large volumes of high-quality, interoperable data. The FAIR (Findable, Accessible, Interoperable, Reusable) Data Principles provide a framework for this, but demand domain-specific implementation strategies. We present nanoPharos, a repository offering ready-for-modelling NMs datasets integrating physicochemical characterisation, mechanistic toxicity, exposure, and risk assessment data, enriched with atomistic, structural, molecular, and periodic table-based descriptors. Built on an adapted ChemBL schema, nanoPharos captures NMs' complexity from unit cell to macroscopic properties, linking rich bibliographic, provenance, and scientific metadata. Case studies demonstrate scalability for advanced materials, while integration with platforms like nanodash and Zenodo enhances FAIRness. Evaluation via Joint Research Centre maturity indicators shows strong compliance, with ongoing work towards full ontology integration and advanced API queries.

新型和先进的材料，包括纳米材料（NMs），对于各种工业和社会应用至关重要，然而传统的研究与创新（R&I）和研究与开发（R&D）可能需要几十年才能达到市场部署。将这些过程数字化，以支持安全和可持续的材料开发，并减少对动物试验的依赖，需要大量高质量、可互操作的数据。FAIR（可查找、可访问、可互操作、可重用）数据原则为此提供了一个框架，但需要特定于领域的实现策略。我们提出了nanoPharos，这是一个存储库，提供现成的建模NMs数据集，集成了物理化学特征、机械毒性、暴露和风险评估数据，丰富了原子、结构、分子和基于元素周期表的描述符。nanoharos建立在ChemBL模式的基础上，捕获了NMs从单位细胞到宏观属性的复杂性，连接了丰富的书目、来源和科学元数据。案例研究展示了先进材料的可扩展性，同时与nanodash和Zenodo等平台的集成增强了公平性。通过联合研究中心成熟度指标进行的评估显示了很强的遵从性，正在进行的工作是实现完整的本体集成和高级API查询。

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引用次数: 0

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