Lipid lowering therapy: implications of recent clinical trials.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Future cardiology Pub Date : 2024-02-01 Epub Date: 2024-01-16 DOI:10.2217/fca-2023-0132
James M Backes, Daniel E Hilleman
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Abstract

Recent lipid lowering therapy trials have provided important insights on certain agents while also continuing to expand our understanding of atherosclerotic cardiovascular disease (ASCVD) risk. Findings from current trials include the impact of statin therapy on ASCVD among populations with HIV, the benefit of lowering low-density lipoprotein cholesterol with bempedoic acid among patients considered statin intolerant, the safety and efficacy of inclisiran over a 4-year period, another failed attempt for fibrates to reduce ASCVD risk, which omega-3 fatty to utilize for lowering cardiovascular events, 'n-of-1' trials evaluating statin intolerance, and how low-dose rosuvastatin compared with commonly utilized supplements for lowering lipid parameters. Such data help inform so clinicians can optimize lipid lowering therapy and improve ASCVD outcomes.

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降脂疗法:近期临床试验的意义。
最近的降脂治疗试验为某些药物提供了重要的启示,同时也继续扩大了我们对动脉粥样硬化性心血管疾病(ASCVD)风险的了解。目前的试验结果包括:他汀类药物治疗对艾滋病病毒感染人群中 ASCVD 的影响;在被认为不能耐受他汀类药物的患者中使用贝门冬氨酸降低低密度脂蛋白胆固醇的益处;为期 4 年的 inclisiran 的安全性和有效性、用纤维酸盐降低 ASCVD 风险的另一次失败尝试、用哪种欧米加-3 脂肪酸降低心血管事件、评估他汀类药物不耐受性的 "n-of-1 "试验,以及小剂量罗伐他汀与常用补充剂在降低血脂参数方面的比较。这些数据有助于为临床医生优化降脂治疗和改善 ASCVD 结果提供信息。
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来源期刊
Future cardiology
Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.80
自引率
5.90%
发文量
87
期刊介绍: Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.
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