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Electrocardiographic and biochemical predictors of left ventricular remodeling early after ST-segment elevation myocardial infarction. ST 段抬高型心肌梗死后早期左心室重塑的心电图和生化预测因素
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-20 DOI: 10.1080/14796678.2024.2424128
Mert Doğan, Uğur Canpolat, Kudret Aytemir

Aim: We aimed to assess low to mid-range left ventricular ejection fraction (LVEF) predictors at one-month follow-up in STEMI patients using baseline electrocardiography (ECG) and standard laboratory tests.Methods: In this retrospective cross-sectional study, 130 STEMI patients (79% male, mean age: 57.2 ± 11.9 years) were enrolled. Multivariate linear regression analysis determined the relationship of baseline 12-lead ECG and clinical/laboratory parameters with LVEF at the 1st-month follow-up visit.Results: The mean LVEF of the patients at the 1st-month follow-up visit was 51.8 ± 8.7%. There was a significant negative correlation between age (r = -0.206)*, peak CK-MB level (-0.0411)**, QTc interval (r = -0.209)*, STE amount (mV) (r = -0.286)**, V5-6 RWPT (r = -0.238)** and aVR RWPT (r = -0.466)** with LVEF (*p < 0.05; **p < 0.01). The aVR R wave peak time (RWPT) (OR: 0.88, p < 0.01) and peak CK-MB level (OR: 0.91, p < 0.01) were the two most important predictors of low-to-mid-range LVEF (<%50) during mean 38 ± 5 days follow-up after STEMI.Conclusion: Our study results suggested that the baseline aVR RWPT and peak CK-MB level were associated with low-to-mid-range LVEF at the 1st-month follow-up after STEMI. These parameters may be used in the risk stratification of STEMI patients to develop LV remodeling during follow-up.

目的:我们旨在利用基线心电图(ECG)和标准实验室检查评估 STEMI 患者随访一个月时左心室射血分数(LVEF)的中低端预测指标:在这项回顾性横断面研究中,共纳入了 130 名 STEMI 患者(79% 为男性,平均年龄为 57.2 ± 11.9 岁)。多变量线性回归分析确定了基线12导联心电图和临床/实验室参数与第一个月随访时LVEF的关系:随访一个月时,患者的平均 LVEF 为 51.8 ± 8.7%。年龄(r = -0.206)*、CK-MB峰值水平(-0.0411)**、QTc间期(r = -0.209)*、STE量(mV)(r = -0.286)**、V5-6 RWPT(r = -0.238)**和aVR RWPT(r = -0.466)**与LVEF之间存在明显的负相关(*p p p p 结论:我们的研究结果表明,患者的基线LVEF与CK-MB峰值水平之间存在明显的负相关:我们的研究结果表明,基线 aVR RWPT 和 CK-MB 峰值水平与 STEMI 后 1 个月随访时低至中等 LVEF 相关。这些参数可用于 STEMI 患者在随访期间发生左心室重构的风险分层。
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引用次数: 0
Severe acute recoil following transcatheter aortic valve replacement with a self-expanding prosthesis in a heavily calcified bicuspid aortic valve. 重度钙化双尖瓣经导管主动脉瓣置换术中使用自膨胀假体后出现严重急性反冲。
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-19 DOI: 10.1080/14796678.2024.2421688
Artemio García-Escobar, Santiago Jiménez-Valero, Guillermo Galeote, Alfonso Jurado-Román, José Ángel Cabrera, Raúl Moreno

Bicuspid aortic valve (BAV) is one of the most common congenital valvular heart diseases occurring in 0.5-2% of the general population, in 2-6% of patients with severe aortic stenosis (AS) and up to 20% of octo/nonagenarians undergoing surgery. In this regard, Transcatheter aortic valve replacement (TAVR) has emerged as a therapeutic alternative. At the present time, there is not enough evidence to determine which is the best therapeutic approach for AS in BAV. We report a severe acute recoil following TAVR with a self-expanding prosthesis in heavily calcified BAV. In addition, we provide an updated review of the clinical significance of prosthesis underexpansion in the medium-term.

主动脉瓣二尖瓣(BAV)是最常见的先天性瓣膜性心脏病之一,在普通人群中的发病率为 0.5-2%,在重度主动脉瓣狭窄(AS)患者中的发病率为 2-6%,在接受手术的八十岁/非老年人中的发病率高达 20%。在这方面,经导管主动脉瓣置换术(TAVR)已成为一种替代治疗方法。目前,还没有足够的证据来确定哪种是治疗 BAV AS 的最佳方法。我们报告了一例严重钙化的 BAV 使用自膨胀假体进行 TAVR 后发生严重急性反跳的病例。此外,我们还对假体中期扩张不足的临床意义进行了最新回顾。
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引用次数: 0
Single-center initial experience with a new pulsed-field ablation system: pulmonary vein isolation lesions and beyond. 使用新型脉冲场消融系统的单中心初步经验:肺静脉隔离病变及其他。
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-19 DOI: 10.1080/14796678.2024.2413829
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Athanasios Kordalis, Christodoulos Stefanadis, Konstantinos Tsioufis

Pulsed-field ablation (PFA) is a newer energy delivery method, an alternative to thermal lesion, allowing for safe and durable pulmonary vein isolation in the context of atrial fibrillation ablation. Graded tissue sensitivity allows for specifically targeting atrial cardiomyocytes, rendering collateral damage to nearby nerves and vessels unlikely. In the present rapid communication, we report on our center's initial experience with a novel PFA platform and describe the ways in which it can be used targeting sites beyond PV ostia and antra, in the context of atrial fibrillation/flutter/tachycardia ablation, alone or in conjunction with a mainstream 3-dimensional electroanatomical mapping system (3D-EAM). More specifically, the exploratory application of PFA in the vicinity of pacemaker/defibrillator leads may prove of particular significance for clinical practice, given the frequent need to isolate the superior vena cava in patients bearing a transvenous cardiac rhythm management device.

脉冲场消融术(PFA)是一种较新的能量传递方法,可替代热损伤,在心房颤动消融术中实现安全、持久的肺静脉隔离。分级组织灵敏度允许专门针对心房心肌细胞,不太可能对附近的神经和血管造成附带损伤。在本快速通讯中,我们报告了本中心使用新型 PFA 平台的初步经验,并介绍了在心房颤动/扑动/心动过速消融术中,该平台可单独或与主流的三维电子解剖图系统(3D-EAM)结合使用,靶向 PV 孔和蚁穴以外的部位。更具体地说,在心脏起搏器/除颤器导联附近探索性地应用 PFA 可能对临床实践具有特别重要的意义,因为携带经静脉心脏节律管理设备的患者经常需要隔离上腔静脉。
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引用次数: 0
Soft drinks, fish oil and atrial fibrillation. 软饮料、鱼油和心房颤动
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-18 DOI: 10.1080/14796678.2024.2420552
Gorm Boje Jensen, Peter Schnohr, Carl J Lavie, James H O'Keefe
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引用次数: 0
Cardiovascular magnetic resonance versus echocardiography derived left ventricular ejection fraction for decision-making. 心血管磁共振与超声心动图得出的左心室射血分数的决策对比。
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-14 DOI: 10.1080/14796678.2024.2426875
Eamon Dhall, Adil Mahmood, Nay Aung, Mohammed Y Khanji
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引用次数: 0
Genetics in clinical cardiology: the current state and opportunities ahead. 临床心脏病学中的遗传学:现状与机遇。
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-14 DOI: 10.1080/14796678.2024.2426883
Anjali Agarwalla, Melissa A Austin, Nosheen Reza
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引用次数: 0
miRNAs in the diagnosis and therapy of cardiac and mediastinal tumors: a new dawn for cardio-oncology? 心脏和纵隔肿瘤诊断与治疗中的 miRNA:心脏肿瘤学的新曙光?
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-08 DOI: 10.1080/14796678.2024.2419225
Francesco Loreni, Antonio Nenna, Francesco Nappi, Chiara Ferrisi, Camilla Chello, Mario Lusini, Bruno Vincenzi, Giuseppe Tonini, Massimo Chello

Dysfunctions in miRNA production have been recently investigated as predictors of neoplasms and their therapeutic strategies. In this review, we summarize the available knowledge on miRNAs and cardiac tumors (such as myxoma) and mediastinal tumors (such as thymoma) and propose new avenues for future research. MiRNAs are crucial for cardiac development through the expression of cardiac transcription factors (miR-335-5p), hinder the cell cycle by modulating the activity of transcription factors (miR-126-3p, miR-320a), modulate the production of inflammatory factors such as interleukins (miR-217), and interfere with cell proliferation or apoptosis (miR-218, miR-634 and miR-122). Current and future research on miRNAs is essential, as a deep understanding could lead to a revolution in the field of diagnostics and prevention of neoplastic diseases.

miRNA 生成的功能障碍最近已被研究为肿瘤及其治疗策略的预测因素。在这篇综述中,我们总结了有关 miRNA 与心脏肿瘤(如肌瘤)和纵隔肿瘤(如胸腺瘤)的现有知识,并提出了未来研究的新途径。miRNA通过表达心脏转录因子(miR-335-5p)对心脏发育至关重要,通过调节转录因子的活性(miR-126-3p、miR-320a)阻碍细胞周期,调节白细胞介素等炎症因子的产生(miR-217),干扰细胞增殖或凋亡(miR-218、miR-634和miR-122)。目前和未来对 miRNA 的研究至关重要,因为深入了解 miRNA 可为肿瘤疾病的诊断和预防领域带来一场革命。
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引用次数: 0
Current and future landscape of cardiogeriatrics. 老年心脏病学的现状与未来。
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-11-07 DOI: 10.1080/14796678.2024.2418761
Akshay Gaur, Abdallah Al-Mohammad, David Warriner
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引用次数: 0
Proton pump inhibitors and cardiovascular risk: a critical review. 质子泵抑制剂与心血管风险:重要综述。
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-28 DOI: 10.1080/14796678.2024.2412910
Gustavo J Duarte, Jose Lopez, Franklin Sosa, Guarina Molina, Mohammed Shaban, Justin Mark, Asma Khizar, Aathira Sreenivasan, An Tran, Miguel Rodriguez Guerra

Proton pump inhibitors (PPI) are widely used medications for gastrointestinal disorders. Recent research suggests a potential association between long-term PPI use and increased cardiovascular (CV) risk, creating a complex clinical dilemma. This review critically evaluates the current evidence for this association, considering the limitations of observational studies and the lack of definitive confirmation from randomized controlled trials.This review delves into the reported association between PPIs and adverse CV events, examining proposed mechanisms such as drug interactions, electrolyte imbalances induced by PPIs and their potential impact on cardiac and vascular function. Evidence suggests these mechanisms converge, with varying influence depending on patient populations.Clinicians require a risk-benefit analysis for each patient considering their CV risk profile. Alternative gastrointestinal therapies should be explored for high-bleeding risk patients. Medications with lower cytochrome-P450 interaction potential may be preferable among essential PPI users. Elucidating the specific mechanisms by which PPIs might influence CV health, assessing long-term vascular effects and investigating interactions with newer anticoagulant medications are crucial for future research.

质子泵抑制剂(PPI)是广泛用于治疗胃肠道疾病的药物。最近的研究表明,长期服用质子泵抑制剂与心血管(CV)风险增加之间可能存在关联,从而造成了复杂的临床难题。考虑到观察性研究的局限性以及缺乏随机对照试验的明确证实,本综述对这一关联的现有证据进行了批判性评估。本综述深入研究了所报道的 PPI 与不良 CV 事件之间的关联,考察了药物相互作用、PPI 引起的电解质失衡及其对心脏和血管功能的潜在影响等拟议机制。有证据表明,这些机制趋于一致,但根据患者人群的不同,其影响也各不相同。对于高出血风险患者,应探索其他胃肠道疗法。对于必须服用 PPI 的患者来说,细胞色素-P450 相互作用可能性较低的药物可能更可取。阐明 PPIs 影响心血管健康的具体机制、评估对血管的长期影响以及调查与新型抗凝药物的相互作用是未来研究的关键。
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引用次数: 0
Contemporary Functional Coronary Angiography: An Update. 当代功能性冠状动脉造影术:最新进展。
IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-24 DOI: 10.1080/14796678.2024.2416817
Josiah Bennett, Sanjay Chandrasekhar, Edward Woods, Patrick McLean, Noah Newman, Brett Montelaro, Hafeez Ul Hassan Virk, Mahboob Alam, Samin K Sharma, Hani Jned, Muzamil Khawaja, Chayakrit Krittanawong

Functional coronary angiography (FCA) is a novel modality for assessing the physiology of coronary lesions, going beyond anatomical visualization by traditional coronary angiography. FCA incorporates indices like fractional flow reserve (FFR) and instantaneous wave-free ratio (IFR), which utilize pressure measurements across coronary stenoses to evaluate hemodynamic impacts and to guide revascularization strategies. In this review, we present traditional and evolving modalities and uses of FCA. We will also evaluate the existing evidence and discuss the applicability of FCA in various clinical scenarios. Finally, we provide insight into emerging evidence, current challenges, and future directions in FCA.

功能性冠状动脉造影术(FCA)是一种评估冠状动脉病变生理学的新模式,它超越了传统冠状动脉造影术的解剖可视化范围。功能性冠状动脉造影结合了分数血流储备(FFR)和瞬时无波比(IFR)等指标,利用测量冠状动脉狭窄处的压力来评估血流动力学影响并指导血管再通策略。在这篇综述中,我们将介绍 FCA 的传统和发展模式及用途。我们还将评估现有证据,并讨论 FCA 在各种临床情况下的适用性。最后,我们将深入探讨 FCA 的新兴证据、当前挑战和未来发展方向。
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引用次数: 0
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Future cardiology
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