Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-12-31 Epub Date: 2024-01-16 DOI:10.1080/15384047.2024.2302924

Qian Du, Meiying Zhang, Aiai Gao, Tao He, Mingzhou Guo

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the most malignant tumor. Zinc finger and SCAN domain-containing protein 23 (ZSCAN23) is a new member of the SCAN domain family. The expression regulation and biological function remain to be elucidated. In this study, we explored the epigenetic regulation and the function of ZSCAN23 in PDAC. ZSCAN23 was methylated in 60.21% (171/284) of PDAC and its expression was regulated by promoter region methylation. The expression of ZSCAN23 inhibited cell proliferation, colony formation, migration, invasion, and induced apoptosis and G1/S phase arrest. ZSCAN23 suppressed Panc10.05 cell xenograft growth in mice. Mechanistically, ZSCAN23 inhibited Wnt signaling by interacting with myosin heavy chain 9 (MYH9) in pancreatic cancer cells. ZSCAN23 is frequently methylated in PDAC and may serve as a detective marker. ZSCAN23 suppresses PDAC cell growth both in vitro and in vivo.

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表观遗传沉默 ZSCAN23 通过激活 Wnt 信号促进胰腺癌生长

胰腺导管腺癌（PDAC）是恶性程度最高的肿瘤。锌指和含 SCAN 结构域蛋白 23（ZSCAN23）是 SCAN 结构域家族的新成员。其表达调控和生物学功能仍有待阐明。本研究探讨了ZSCAN23在PDAC中的表观遗传调控及其功能。在60.21%（171/284）的PDAC中，ZSCAN23被甲基化，其表达受启动子区甲基化调控。ZSCAN23的表达可抑制细胞增殖、集落形成、迁移和侵袭，并诱导细胞凋亡和G1/S期停滞。ZSCAN23抑制了Panc10.05细胞在小鼠体内的异种移植生长。从机理上讲，ZSCAN23通过与胰腺癌细胞中的肌球蛋白重链9（MYH9）相互作用来抑制Wnt信号转导。ZSCAN23在PDAC中经常发生甲基化，可作为一种检测标记物。ZSCAN23 在体外和体内都能抑制 PDAC 细胞的生长。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.