Oral and rectal colonization of methicillin-resistant Staphylococcus aureus in long-term care facility residents and their association with clinical status

IF 1.9 4区 医学 Q4 IMMUNOLOGY Microbiology and Immunology Pub Date : 2024-01-17 DOI:10.1111/1348-0421.13111
Satoru Kusaka, Azusa Haruta, Miki Kawada-Matsuo, Mi Nguyen-Tra Le, Mineka Yoshikawa, Toshiki Kajihara, Koji Yahara, Junzo Hisatsune, Ryota Nomura, Kazuhiro Tsuga, Hiroki Ohge, Motoyuki Sugai, Hitoshi Komatsuzawa
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Abstract

Staphylococcus aureus is a commensal bacterium in humans, but it sometimes causes opportunistic infectious diseases such as suppurative skin disease, pneumonia, and enteritis. Therefore, it is important to determine the prevalence of S. aureus and methicillin-resistant S. aureus (MRSA) in individuals, especially older adults. In this study, we investigated the prevalence of S. aureus and MRSA in the oral cavity and feces of residents in long-term care facilities (LTCFs). S. aureus was isolated from the oral cavity of 61/178 (34.3%) participants, including 28 MRSA-positive participants (15.7%), and from the feces of 35/127 (27.6%) participants, including 16 MRSA-positive participants (12.6%). S. aureus and MRSA were isolated from both sites in 19/127 individuals (15.0%) and 10/127 individuals (7.9%), respectively. Among 19 participants with S. aureus isolation from both sites, 17 participants showed the same sequence type (ST) type. Then, we analyzed the correlation of S. aureus and MRSA in the oral cavity and rectum with the participant's condition. S. aureus and MRSA positivity in the oral cavity was significantly related to tube feeding, while there was no correlation of rectal S. aureus/MRSA with any factors. Our findings regarding the oral inhabitation of MRSA and its risk factors indicate the importance of considering countermeasures against MRSA infection in LTCFs.

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长期护理机构居民耐甲氧西林金黄色葡萄球菌的口腔和直肠定植及其与临床状况的关系。
金黄色葡萄球菌是人类的一种共生细菌,但它有时也会引起机会性传染病,如化脓性皮肤病、肺炎和肠炎。因此,确定金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌(MRSA)在个人,尤其是老年人中的流行率非常重要。在本研究中,我们调查了长期护理机构(LTCF)居民口腔和粪便中金黄色葡萄球菌和 MRSA 的流行情况。从 61/178 名参与者(34.3%)的口腔中分离出了金黄色葡萄球菌,其中包括 28 名 MRSA 阳性参与者(15.7%);从 35/127 名参与者(27.6%)的粪便中分离出了金黄色葡萄球菌,其中包括 16 名 MRSA 阳性参与者(12.6%)。分别有 19/127 人(15.0%)和 10/127 人(7.9%)从这两个部位分离出了金黄色葡萄球菌和 MRSA。在同时从两个部位分离出金葡菌的 19 人中,有 17 人的序列类型(ST)相同。然后,我们分析了口腔和直肠中的金黄色葡萄球菌和 MRSA 与参与者病情的相关性。口腔中的金黄色葡萄球菌和 MRSA 阳性与插管喂养明显相关,而直肠中的金黄色葡萄球菌/MRSA 与任何因素均无相关性。我们关于口腔中 MRSA 的栖息地及其风险因素的研究结果表明,考虑在 LTCF 中采取预防 MRSA 感染的对策非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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