Administration of ivermectin to cattle induced mortality, reduced fecundity and survivorship of Anopheles arabiensis in Ethiopia: an implication for expansion of vector control toolbox.

IF 3.6 Q1 TROPICAL MEDICINE Tropical Medicine and Health Pub Date : 2024-01-16 DOI:10.1186/s41182-023-00575-z
Ephrem Damene, Fekadu Massebo
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Abstract

Background: Although many countries have shown interest in eliminating malaria, approaches that complement existing vector control interventions are needed because existing methods have been scaled up but malaria still persists. Therefore, the effect of ivermectin administration to cattle was evaluated for its effect on mortality, survivorship and mortality of laboratory reared Anopheles arabiensis.

Methods: Three calves were randomly selected and injected with ivermectin at a therapeutic dose of 0.2 mg/kg, while the other two calves received no treatment and served as controls. Five tents were constructed for the trial. Calves were housed in tents (one per tent) and then 30 starved female An. arabiensis were introduced into each tent. Only fully engorged females were collected from each tent and placed in different mosquito cages to monitor their mortality, survival and fecundity. Data analysis was done using SPSS version 16.

Results: During the follow-up period (until day 21), ivermectin induced significantly higher mortality when compared to controls. It resulted in an average 24-h mortality rate of 81.6% against An. arabiensis on the first day following treatment. 100% An. arabiensis that fed on ivermectin-treated calves on the first day after treatment died within four days. Egg production rate of An. arabiensis that fed on ivermectin-treated calves was significantly lower compared to controls (F = 768.7, P < 0.001).

Conclusion: In conclusion, ivermectin induced mortality, reduced fecundity and survivorship of laboratory maintained An. arabiensis. Further study is recommended using a wild mosquito population. Moreover, mass ivermectin administration to domestic animals could be recommended to supplement the existing indoor based interventions.

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在埃塞俄比亚,对牛施用伊维菌素会导致阿拉伯按蚊死亡、繁殖力下降和存活率降低:对扩大病媒控制工具箱的影响。
背景:尽管许多国家都对消除疟疾表现出兴趣,但由于现有方法已得到推广,但疟疾仍持续存在,因此需要采取补充现有病媒控制干预措施的方法。因此,本研究评估了给牛注射伊维菌素对死亡率、存活率和实验室饲养的阿拉伯按蚊死亡率的影响:方法:随机选取三头牛犊,按 0.2 毫克/千克的治疗剂量注射伊维菌素,另外两头牛犊不接受治疗,作为对照组。试验共搭建了五个帐篷。犊牛被安置在帐篷中(每个帐篷一只),然后每个帐篷引入 30 只饥饿的雌性阿拉伯疟原虫。从每个帐篷中只收集完全充血的雌蚊,并将其放入不同的蚊笼中,以监测其死亡率、存活率和繁殖力。数据分析采用 SPSS 16.0 版:在随访期间(直到第 21 天),伊维菌素导致的死亡率明显高于对照组。治疗后第一天,伊维菌素对阿拉伯蚁的 24 小时平均死亡率为 81.6%。经伊维菌素处理的犊牛在处理后的第一天就100%死亡。与对照组相比,取食伊维菌素处理过的犊牛的阿拉伯蚁产卵率明显降低(F = 768.7,P 结论:伊维菌素处理过的犊牛的产卵率明显低于对照组(F = 768.7,P):总之,伊维菌素会导致实验室饲养的阿拉伯疟蚊死亡,降低繁殖力和存活率。建议使用野生蚊子种群进行进一步研究。此外,建议对家养动物大规模施用伊维菌素,以补充现有的室内干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tropical Medicine and Health
Tropical Medicine and Health TROPICAL MEDICINE-
CiteScore
7.00
自引率
2.20%
发文量
90
审稿时长
11 weeks
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